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| 1 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 2 | Cloning and characterization of the thyroid iodide transporter显示文摘 | Dai G Levy O Carrasco N | 1996 | Nature1996，379，： | 2 |
| 3 | Cloning and charaeterization of the thyroid iodide transporter显示文摘 | Levy O-Carrasco N | 1996 | Nature1996，379，： | 1 |
| 4 | Correcting immune imbalance:the use of Prosorba column treatment for immune disorders显示文摘 | Levy J Degani N | 2003 | Ther Apher Dial2003，7，2： | 1 |
| 5 | Increased C-reac-tive protein levels in the polycystic ovary syndrome:a markerof cardiovascular disease显示文摘 | BOULMAN N LEVY Y LEIBA R | 2004 | J Clin Endocrinol Metab2004，89，5： | 1 |
| 6 | A correlation between the pretransplantation MELD score and mortality in the first two years after liver transplantation显示文摘 | Onaca N N Levy M F Sanchez E Q | 2003 | Liver Transpl2003，9，： | 1 |
| 7 | Nitrogen fixation : Anthropogenic enhancement environmental response显示文摘 | Galloway J N W H Schlesinger H Levy Ⅱ | 1995 | Global Biogeochem Cycles1995，9，： | 1 |
| 8 | Characterisation of Electrodeposited Nanocrystalline Ni-Mo Alloys 显示文摘 | CHASSAING E PORTAIL N LEVY A | 2004 | Journal of Applied Electrochemistry2004，34，11： | 1 |
| 9 | Compassion fatigue, burnout and compassion satisfaction among family physicians in the Negev area - a cross-sectional study 显示文摘 | El-Bar N Levy A Wald HS | 2013 | Isr J Health Policy Res2013，2，1： | 1 |
| 10 | Inhibition of cusp and aortic wall calcifieation in ethanol and aluminum treated bioprosthetic heart valves in sheep background, mechanisms, and synergism 显示文摘 | Levy RJ Vyavahare N Ogle M | 2003 | The Journal of Heart Valve Disease2003，12，2： | 1 |
| 11 | Cloning and character i zation of the thyroid iodide tranporter显示文摘 | Dai G Levy O Carrasco N | 1996 | Nature1996，379，： | 1 |
| 12 | Rosiglitazone (PPARgamma-agonist) attenuates atherogenesis with no effect on hyperglycaemia in a combined diabetes atherosclerosis mouse model显示文摘 | Levi Z Shaish A Yacov N | 2003 | Diabetes Obes Metab2003，5，1： | 1 |
| 13 | The Yes-associated pro- tein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73显示文摘 | Levy D Adamovich Y Reuven N | 2007 | Cell Death Differ2007，14，4： | 1 |
| 14 | Experimental results and performance analysis of a 500 m/mec linear induction launcher (LIL)显示文摘 | Zabar Z Lu X N Levi E | 1995 | IEEE Transactions on Magnetics1995，31，1： | 1 |
| 15 | Design and baseline characteristics of the soy phytoestrogens as replacement estrogen (SPARE) study-A clinical trial of the effects of soy isoflavones in menopausal women显示文摘 | Levis S Strickman-Stein N Doerge D R | 2010 | Contemporary Clinical Trials2010，31，4： | 1 |
| 16 | Soy isoflavones in the prevention of menopausal bone loss and menopausal symptoms:a randomized,double-blind trial显示文摘 | Levis S Strickman-Stein N Ganjei-Azar P | | 0，，15： | 1 |
| 17 | Physico-chemical aspects in flocculation of bentonite suspensions by a cyanobacterial bioflocculant 显示文摘 | Levy N Assis M | 1992 | Water Research1992，26，2： | 1 |
| 18 | The Part - through Surface Cracks in an Elastic Plate 显示文摘 | Rice J R Levy N J | 1972 | Journal of Applied Mechanics1972，39，： | 1 |
| 19 | Cloning and characterization of the thyroid iodide transporter显示文摘 | Dai G Levy O Carrasco N | 1996 | Nature1996，379，： | 1 |
| 20 | Mediastinal cancer presenting as dermatomyositis--a case report 显示文摘 | Hassoun N Agabrya A Levy Y | 2011 | Harefuah2011，150，57： | 1 |
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