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| 1 | 危重患者抗菌药物持续静脉滴注或延长滴注时间:系统综述和meta分析显示文摘危重患者抗菌药物持续静脉滴注或延长滴注时间:系统综述和meta分析
摘译:本研究对入住ICU危重患者使用以药物代谢动力学为基础的方法行抗菌药物持续静脉滴注或延长静脉滴注时间,并与传统间歇性静脉滴注抗菌药物进行比较,观察包括病死率在内的各种预后变化。 | 罗勇 Chant C Leung A Frienrich J O | 2014 | 临床误诊误治2014，27，8： | 3 |
| 2 | Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics显示文摘Background and purpose Symptomatic intracranial atherosclerotic stenosis(sICAS)is associated with a considerable risk of recurrent stroke despite contemporarily optimal medical treatment.Severity of luminal stenosis in sICAS and its haemodynamic significance quantified with computational fluid dynamics(CFD)models were associated with the risk of stroke recurrence.We aimed to develop and compare stroke risk prediction nomograms in sICAS,based on vascular risk factors and these metrics.Methods Patients with 50%-99%sICAS confirmed in CT angiography(CTA)were enrolled.Conventional vascular risk factors were collected.Severity of luminal stenosis in sICAS was dichotomised as moderate(50%-69%)and severe(70%-99%).Translesional pressure ratio(PR)and wall shear stress ratio(WSSR)were quantified via CTA-based CFD modelling;the haemodynamic status of sICAS was classified as normal(normal PR&WSSR),intermediate(otherwise)and abnormal(abnormal PR&WSSR).All patients received guideline-recommended medical treatment.We developed and compared performance of nomograms composed of these variables and independent predictors identified in multivariate logistic regression,in predicting the primary outcome,recurrent ischaemic stroke in the same territory(SIT)within 1 year.Results Among 245 sICAS patients,20(8.2%)had SIT.The D2H2A nomogram,incorporating diabetes,dyslipidaemia,haemodynamic status of sICAS,hypertension and age≥50 years,showed good calibration(P for Hosmer-Lemeshow test=0.560)and discrimination(C-statistic 0.73,95%CI 0.60 to 0.85).It also had better performance in risk reclassification and provided larger net benefits in decision curve analysis,compared with nomograms composed of conventional vascular risk factors only,and plus the severity of luminal stenosis in sICAS.Sensitivity analysis in patients with anterior-circulation sICAS showed similar results.Conclusions The D2H2A nomogram,incorporating conventional vascular risk factors and the haemodynamic significance of sICAS as assessed in CFD models,could be a useful tool to stratify sICAS patients for the risk of recurrent stroke under contemporarily optimal medical treatment. | Xuan Tian Hui Fang Linfang Lan Hing Lung Ip Jill Abrigo Haipeng Liu Lina Zheng Florence S Y Fan Sze Ho Ma Bonaventure Ip Bo Song Yuming Xu Jingwei Li Bing Zhang Yun Xu Yannie O Y Soo Vincent Mok Ka Sing Wong Thomas W Leung Xinyi Leng | 2023 | Stroke & Vascular Neurology2023，8，1： | 2 |
| 3 | Timing of hyperoxic exposure during alveolarization influences damage mediated by leukotrienes显示文摘 | O′Kelly CJ Leung WI | 2001 | Am J Physiol Lung Cell Mol Physiol2001，281，4： | 1 |
| 4 | Genetic diversity of Chinese native chicken breeds based on protein polymorphism, randomly amplified polymorphic DNA, and microsatellite polymorphism显示文摘 | Zhang X Leung F C Chan D K O | 2002 | Poultry Science2002，81，： | 1 |
| 5 | A review on the usage of POP pesticides in China, with emphasis on DDT loading in human milk 显示文摘 | Wong M H Leung A O W Chart J K Y | 2005 | Chemosphere2005，60，6： | 1 |
| 6 | Evidence for a lacal angiotensin system and dose-dependent inhibiton of glucose-stimulated insulin release by angiotensin Ⅱ in isolated pancreatic islets显示文摘 | LAU T CARLSSON P O LEUNG P S | 2004 | Diabetologia2004，47，2： | 1 |
| 7 | Better Survival in Female Patients With Hepatocellular Carcinoma: Oral Contraceptive Pills Related?显示文摘 | Chi Ming Lam Jamy L Yong Annie O Chan Kelvin K Ng Ronnie T Poon Chi Leung Liu Chung Mau Lo Sheung Tat Fan | 2005 | Journal of Clinical Gastroenterology2005，，6： | 1 |
| 8 | A robust optimization model for multi - site produetion planning problem in a uncertain enviroment 显示文摘 | LEUNG S C H TSANG S O S NG W L | 2007 | European Journal of Oprational Research2007，，181： | 1 |
| 9 | Heavy metals concentrations of surface dust from e-waste recycling and its human health implications in southeast China 显示文摘 | Leung A O W Duzgoren-Aydin N S Cheung K C | 2008 | Environmental Science and Technology2008，42，7： | 1 |
| 10 | Spatial distribution of polybrominated diphenyl ethers and polychlorinated dibenzo-p-dioxins and dibenzofurans in soil and cornbusted residue at Guiyu, an electronic waste recycling site in Southeast China 显示文摘 | Leung A O Luksenburg W J Wong A S | 2007 | Environmental Science and Technology2007，41，8： | 1 |
| 11 | Simple model for transient soil loading in earthquake analysis(I):basic model and its application显示文摘 | ZIENKIEWICZ O C LEUNG K H PASTOR M | 1985 | International Journal for Numerical and Analytical Methods in Geomechanics1985，9，3： | 1 |
| 12 | The identification of di- palmitylzeaxanthin as the major carotenoid in Gou Qi Zi by high pressure liquid chromatography and mass spectrometry 显示文摘 | Zhou L Leung I Tso M O | 1999 | J Ocul Pharmacol Ther1999，15，： | 1 |
| 13 | Reliable universal,RT-PCR assaysfor studying influenza polymerasesubunit gene sequences from all 16haemagglutinin subtypes显示文摘 | Li O Barr I Leung C | 2007 | Journal of Virological Methods2007，142，1： | 1 |
| 14 | An overview of packet reordering in transmission control protoeol(TCP): problems, solutions, and chal- lenges显示文摘 | LEUNG K C LIV O K YANG D | 2007 | IEEE Transactions on Parallel and Distributed Systems2007，18，4： | 1 |
| 15 | 显示文摘 | Leung A C W Chong J H Patrick B O | 2003 | Macromolecules2003，36，14： | 1 |
| 16 | Simple model for transient soil loading in earthquake analysis(II):non-associative models for sands显示文摘 | PASTOR M ZIENKIEWICZ O C LEUNG K H | 1985 | International Journal for Numerical and Analytical Methods in Geomechanics1985，9，3： | 1 |
| 17 | The development and validation of a dynamic fracture propagation model for gas transmission pipelines显示文摘 | O'Donoghue P E Kanninen M F Leung C P | 1997 | Int J Pres Ves Pip1997，70，1： | 1 |
| 18 | Intra-arterial thrombolysis of occluded middle cerebral artery by use of collateral pathways in patients with tandemcervical carotid artery/middle cerebral artery occlusion显示文摘 | Ozdemir O Bussière M Leung A | 2008 | AJNR2008，29，： | 1 |
| 19 | Spatial distribution of polybrominated diphenyl ethers and polychlorinated dibenzo-p-dioxins and dibenzofurans in soil and combusted residue at Guiyu,an electronic waste recycling site in Southeast China显示文摘 | Leung A O Luksemburg W J Anthonys A S Wong M H | | 0，，08： | 1 |
| 20 | Polychlorinated dibenzo-p-dioxins and dibenzofurans pollution in China: Sources, environmental levels and potential human health impacts 显示文摘 | Zheng G J Leung A O W Jiao L P | 2008 | Environment International2008，34，： | 1 |
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