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| 1 | Antioxidative and anti-endotoxin effects of propofol on endothelial cells显示文摘Objective To investigate the antioxidant and anti-endotoxin effects of propofol on endothelial cells and the possible mechanisms.Methods Cultured endothelial cells were treated with hydrogen peroxide (H 2O 2), propofol + H 2O 2, lipopolysaccharide (LPS) and propofol + LPS, respectively. Endothelial cell damage was monitored for possible lactic dehydrogenase (LDH) release. The transcription and the protein expression levels of endothelial nitric oxide synthase (eNOS) were measured.Results LDH release was higher in groups treated with H 2O 2 or LPS than in the control group. After pretreatment with propofol, the effects induced by H 2O 2 were attenuated, but propofol did not decrease the LDH release induced by LPS. Both H 2O 2 and LPS significantly increased the eNOS transcript levels and the increases were significantly attenuated after pretreatment with propofol. Both H 2O 2 and LPS significantly increased the eNOS protein expression and the increase was attenuated after pretreatment with propofol. Conclusion Propofol could protect endothelial cells against oxidative stress by inhibiting eNOS transcription and protein expression, but could not antagonise endotoxin induced cell injuries. | 彭志勇 罗敏 叶仕桥 Critchley Lester AH Joynt Gavin M Ho Anthony MH 姚尚龙 | 2003 | Chinese Medical Journal2003，，5： | 7 |
| 2 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 3 | Conditions influencing the precipitation of magnesium ammonium phosphate 显示文摘 | Stratful I Scrimshaw M Lester J | 2001 | Water Res2001，35，17： | 1 |
| 4 | Comparison of bacterial extracellular polymer extraction methods 显示文摘 | Brown M J Lester J N | 1980 | Applied and Environmental Microbiology1980，40，2： | 1 |
| 5 | Initial public offering investor valuations: an examination of top management team prestige and environmental uncertainty 显示文摘 | Lester R H Certo S T Dalton C M Dalton D R Cannella A A | 2006 | Journal of Small Business Management2006，44，1： | 1 |
| 6 | Conditions influencing the precipitation of magnesium ammonium phosphate显示文摘 | Stratful I Scrimshaw M D Lester J N | 2001 | Water Res2001，35，17： | 1 |
| 7 | Muskmelon fruit soluble acid invertase and sucrose phosphate synthase activity and polypeptide profiles during growth and maturation显示文摘 | LESTER G E ARIAS L S L LIM M G | 2001 | J Amer Soc Hort Sci2001，126，： | 1 |
| 8 | Acceleration ofpolyacrylamide photopolymerization using lyotropic liquid crystaltemplates显示文摘 | LESTER C L SMITH S M GUYMON C A | 2001 | Macromolecules2001，34，： | 1 |
| 9 | Two Graph Searching Techniques for Boundary Finding in White Blood Cell Image显示文摘 | J M Lester H A Williams B A Weintraub | 1978 | Computers in Biology and Medicine1978，，8： | 1 |
| 10 | Upregulation of β3-adrenoreptors and altered contractile response to inotropic amines in human failing myocardium显示文摘 | Stephane M Lester K Olivier F | 2001 | Circulation2001，103，： | 1 |
| 11 | Erythropoietin promotes MCF-7 breast cancer cell migration by an ERK/mitogen-activated protein kinase-dependent pathway and is primarily responsible for the increase in migration observed in hypoxia显示文摘 | Lester R D Jo M Campana W M | 2005 | J Biol Chem2005，280，39： | 1 |
| 12 | High dislocation densities in high efficiency GaN-based light-emitting di- odes显示文摘 | Lester S Ponce F Craford M | 1995 | Applied Physics Letters1995，66，： | 1 |
| 13 | The Impact of Psychological Contract Fulfillment on the Performance of in-role and Organizational Citizenship Behaviors显示文摘 | Turnley W H Bolino M C Lester S W | 2003 | Journal of Management2003，29，： | 1 |
| 14 | The crisis of the nonprofit sector and the challenge of renewal显示文摘 | Lester M Salamon | | National Civic Review 00279013 Winter960，，： | 1 |
| 15 | Carotene and novel apocarotenoid concentrations in orange-fleshed Cucumis melo melons- Determinations of fl-carotene bioaccessibility and bioavailability显示文摘 | Fleshman M K Lester G E Riedl K M | 2011 | Journal of Agrieultural and Food Chemistry2011，59，9： | 1 |
| 16 | Organophosphate poisoning-Intermediate syndrome? 显示文摘 | Lester M | 1992 | Toxicol Clin Toxicol1992，30，3： | 1 |
| 17 | A multiplex RT-PCR Assay for the Rapid and Differential Diagnosis of Classical Swine Fever and Other Pestivirus infections显示文摘 | Heidy D Lester J Perez M | 2009 | Veterinary Microbiology2009，139，34： | 1 |
| 18 | Characterization of Hydraulic Fracturing Flowback Water in Colorado: Implica- tions for Water Treatment 显示文摘 | Lester Y Ferrer I Thurman E M | 2015 | Science of the Total Environ- ment2015，，： | 1 |
| 19 | Low spatial-contrast sensitivity in dry eyes显示文摘 | Ralando M Lester M macn A | 1998 | cornea1998，17，： | 1 |
| 20 | The Maternal Lifestyle Study:drug use by meconium toxicology and maternal self-report显示文摘 | Sohly M Wright LL | 2001 | Pediatrics2001，107，2： | 1 |
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