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| 1 | Ulinastatin for acute lung injury and acute respiratory distress syndrome: A systematic review and meta-analysis显示文摘AIM: To investigate the efficacy and safety of ulinastatin for patients with acute lung injury(ALI) and those with acute respiratory distress syndrome(ARDS).METHODS: A systematic review of randomized controlled trials(RCTs) of ulinastatin for ALI/ARDS was conducted. Oxygenation index, mortality rate [intensive care unit(ICU) mortality rate, 28-d mortality rate] and length of ICU stay were compared between ulinastatin group and conventional therapy group. Meta-analysis was performed by using Rev Man 5.1.RESULTS: Twenty-nine RCTs with 1726 participants were totally included, the basic conditions of which were similar. No studies discussed adverse effect. Oxygenation index was reported in twenty-six studies(1552 patients). Ulinastatin had a significant effect in improving oxygenation [standard mean difference(SMD) = 1.85, 95%CI: 1.42-2.29, P < 0.00001, I2 = 92%]. ICUmortality and 28-d mortality were respectively reported in eighteen studies(987 patients) and three studies(196 patients). We found that ulinastatin significantly decreased the ICU mortality [I2 = 0%, RR = 0.48, 95%CI: 0.38-0.59, number needed to treat(NNT) = 5.06, P < 0.00001], while the 28-d mortality was not significantly affected(I2 = 0%, RR = 0.78, 95%CI: 0.51-1.19, NNT = 12.66, P = 0.24). The length of ICU stay(six studies, 364 patients) in the ulinastatin group was significantly lower than that in the control group(SMD =-0.97, 95%CI:-1.20--0.75, P < 0.00001, I2 = 86%). CONCLUSION: Ulinastatin seems to be effective for ALI and ARDS though most trials included were of poor quality and no information on safety was provided. | Yu-Xin Leng Shu-Guang Yang Ya-Han Song Xi Zhu Gai-Qi Yao | 2014 | World Journal of Critical Care Medicine2014，3，1： | 61 |
| 2 | Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study显示文摘Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937). | Hui Zhang Chuan-Ling Li Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan | 2020 | Neural Regeneration Research2020，15，7： | 54 |
| 3 | Numerical and Experimental Investigation of High-efficiency Axial-flow Pump显示文摘The experimental investigation of axial-flow pump has been rapidly developed to meet the needs of South-to-North Water Diversion Project of China. Owing to the boundary conditions of hub, blade tip clearance, much of the physical phenomena and laws involved in this complex flow field can’t be fully determined. The flow characteristics of the high efficiency axial-flow pump have been simulated by RNG k –ε turbulence model and SIMPLEC arithmetic based on FLUENT software. Numerical results indicate that the data from the prediction show agreement with the experimental results, static pressure on pressure side of blades increases slightly at circumferential direction with radius increasing, and keep almost constant at the same radial while increasing gradually from inlet to exit on the suction side along flow direction at design conditions. The static pressure, total pressure and velocity at inlet, impeller outlet and vane outlet were measured by a five-hole probe, and a contrastive experiment was done to investigate the influence of hub leakage. The experimental results show that inlet flow is almost axial and the prerotation is very small at various conditions. The meridional velocity and circulation distribution are almost identical at impeller outlet at design conditions due to steady flow and high efficiency. The residual circulation exits at downstream of the guide vane, and the circumferential velocity component increases linearly from hub to tip at small flow rate conditions. Hub leakage in adjustable blades results in the decrease of the meridional velocity and circulation at blade exit near hub. The results of numerical simulation and experiments supply important flow structure information for the high-efficiency axial-flow pump. | SHI Weidong ZHANGDesheng GUAN Xingfan LENG Hongfei | 2010 | Chinese Journal of Mechanical Engineering2010，23，1： | 50 |
| 4 | Anatomical distribution of pelvic deep infiltrating endometriosis and its relationship with pain symptoms显示文摘背景子宫内膜增生是渗入子宫内膜增生的争论、神秘的 disease.Deep (死)为痛苦的症状负责并且是 endometriosis.Little 工作的最少的理解的类型被奉献了定义地点死有 pain.The 的损害和它的关系学习瞄准是调查在解剖分发之间的关系死损害和疼痛 symptoms.Methods 从在2003年5月和2007年12月与之间的 354 个病人的临床的数据 | Dai Yi Leng Jin-hua Lang Jing-he Li Xiao-yan Zhang Jun-ji | 2012 | Chinese Medical Journal2012，，2： | 43 |
| 5 | 老年人衰弱综合征的发病机制和评估及管理显示文摘随着全球老龄化和衰老与疾病相关研究的深入,衰弱已经成为现代老年医学研究的热点问题之一。衰弱是一种常见的重要老年综合征,表现为机体的脆弱性增加,维持稳态的能力下降,面对各种应激时,发病和死亡的风险增加。其核心特点是多个生理系统(神经肌肉、代谢及免疫系统等)的储备功能下降。 | 宁晓暄 欧阳敏 Leng Sean X | 2015 | 中华老年医学杂志2015，34，12： | 50 |
| 6 | Guidelines for evaluation and management of cerebral collateral circulation in ischaemic stroke 2017显示文摘Collateral circulation plays a vital role in sustaining blood flow to the ischaemic areas in acute,subacute or chronic phases after an ischaemic stroke or transient ischaemic attack.Good collateral circulation has shown protective effects towards a favourable functional outcome and a lower risk of recurrence in stroke attributed to different aetiologies or undergoing medical or endovascular treatment.Over the past decade,the importance of collateral circulation has attracted more attention and is becoming a hot spot for research.However,the diversity in imaging methods and criteria to evaluate collateral circulation has hindered comparisons of findings from different cohorts and further studies in exploring the clinical relevance of collateral circulation and possible methods to enhance collateral flow.The statement is aimed to update currently available evidence and provide evidence-based recommendations regarding grading methods for collateral circulation,its significance in patients with stroke and methods under investigation to improve collateral flow. | Liping Liu Jing Ding Xinyi Leng Yuehua Pu Li-An Huang Anding Xu Ka Sing Lawrence Wong Xin Wang Yongjun Wang 无 | 2018 | Stroke & Vascular Neurology2018，3，3： | 37 |
| 7 | Analysis of risk factors for postoperative pancreatic fistula following pancreaticoduodenectomy显示文摘AIM:To explore the morbidity and risk factors of postoperative pancreatic fistula(POPF)following pancreaticoduodenectomy.METHODS:The data from 196 consecutive patients who underwent pancreaticoduodenectomy,performed by different surgeons,in the General Hospital of the People’s Liberation Army between January 1st,2013and December 31st,2013 were retrospectively collected for analysis.The diagnoses of POPF and clinically relevant(CR)-POPF following pancreaticoduodenectomy were judged strictly by the International Study Group on Pancreatic Fistula Definition.Univariate analysis was performed to analyze the following factors:patient age,sex,body mass index(BMI),hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pancreatic duct diameter,pylorus preserving pancreaticoduodenectomy,pancreatic drainage and pancreaticojejunostomy.Multivariate logistic regression analysis was used to determine the main independent risk factors for POPF.RESULTS:POPF occurred in 126(64.3%)of the patients,and the incidence of CR-POPF was 32.7%(64/196).Patient characteristics of age,sex,BMI,hypertension,diabetes mellitus,serum CA19-9 level,history of jaundice,serum albumin level,blood loss volume,pylorus preserving pancreaticoduodenectomy and pancreaticojejunostomy showed no statistical difference related to the morbidity of POPF or CR-POPF.Pancreatic duct diameter was found to be significantly correlated with POPF rates by univariate analysis and multivariate regression analysis,with a pancreatic duct diameter≤3 mm being an independent risk factor for POPF(OR=0.291;P=0.000)and CR-POPF(OR=0.399;P=0.004).The CR-POPF rate was higher in patients without external pancreatic stenting,which was found to be an independent risk factor for CR-POPF(OR=0.394;P=0.012).Among the entire patient series,there were three postoperative deaths,giving a total mortality rate of 1.5%(3/196),and the mortality associated with pancreatic fistula was 2.4%(3/126).CONCLUSION:A pancreatic duct diameter≤3 mm is an independent risk factor for POPF.External stent drainage of pancreatic secretion may reduce CR-POPF mortality and POPF severity. | Qi-Yu Liu Wen-Zhi Zhang Hong-Tian Xia Jian-Jun Leng Tao Wan Bin Liang Tao Yang Jia-Hong Dong | 2014 | World Journal of Gastroenterology2014，20，46： | 32 |
| 8 | Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan,China:a retrospective study显示文摘Background:The 2019 novel coronavirus has caused the outbreak of the acute respiratory disease in Wuhan,Hubei Province of China since December 2019.This study was performed to analyze the clinical characteristics of patients who succumbed to and who recovered from 2019 novel coronavirus disease(COVID-19).Methods:Clinical data were collected from two tertiary hospitals in Wuhan.A retrospective investigation was conducted to analyze the clinical characteristics of fatal cases of COVID-19(death group)and we compare them with recovered patients(recovered group).Continuous variables were analyzed using the Mann-WhitneyU test.Categorical variables were analyzed byχ2 test or Fisher exact test as appropriate.Results:Our study enrolled 109 COVID-19 patients who died during hospitalization and 116 recovered patients.The median age of the death group was older than the recovered group(69[62,74]vs.40[33,57]years,Z=9.738,P<0.001).More patients in the death group had underlying diseases(72.5%vs.41.4%,χ2=22.105,P<0.001).Patients in the death group had a significantly longer time of illness onset to hospitalization(10.0[6.5,12.0]vs.7.0[5.0,10.0]days,Z=3.216,P=0.001).On admission,the proportions of patients with symptoms of dyspnea(70.6%vs.19.0%,χ2=60.905,P<0.001)and expectoration(32.1%vs.12.1%,χ2=13.250,P<0.001)were significantly higher in the death group.The blood oxygen saturation was significantly lower in the death group(85[77,91]%vs.97[95,98]%,Z=10.625,P<0.001).The white blood cell(WBC)in death group was significantly higher on admission(7.23[4.87,11.17]vs.4.52[3.62,5.88]×109/L,Z=7.618,P<0.001).Patients in the death group exhibited significantly lower lymphocyte count(0.63[0.40,0.79]vs.1.00[0.72,1.27]×109/L,Z=8.037,P<0.001)and lymphocyte percentage(7.10[4.45,12.73]%vs.23.50[15.27,31.25]%,Z=10.315,P<0.001)on admission,and the lymphocyte percentage continued to decrease during hospitalization(7.10[4.45,12.73]%vs.2.91[1.79,6.13]%,Z=5.242,P<0.001).Alanine transaminase(22.00[15.00,34.00]vs.18.70[13.00,30.38]U/L,Z=2.592,P=0.010),aspartate transaminase(34.00[27.00,47.00]vs.22.00[17.65,31.75]U/L,Z=7.308,P<0.001),and creatinine levels(89.00[72.00,133.50]vs.65.00[54.60,78.75]μmol/L,Z=6.478,P<0.001)were significantly higher in the death group than those in the recovered group.C-reactive protein(CRP)levels were also significantly higher in the death group on admission(109.25[35.00,170.28]vs.3.22[1.04,21.80]mg/L,Z=10.206,P<0.001)and showed no significant improvement after treatment(109.25[35.00,170.28]vs.81.60[27.23,179.08]mg/L,Z=1.219,P=0.233).The patients in the death group had more complications such as acute respiratory distress syndrome(ARDS)(89.9%vs.8.6%,χ2=148.105,P<0.001),acute cardiac injury(59.6%vs.0.9%,χ2=93.222,P<0.001),acute kidney injury(18.3%vs.0%,χ2=23.257,P<0.001),shock(11.9%vs.0%,χ2=14.618,P<0.001),and disseminated intravascular coagulation(DIC)(6.4%vs.0%,χ2=7.655,P=0.006).Conclusions:Compared to the recovered group,more patients in the death group exhibited characteristics of advanced age,pre-existing comorbidities,dyspnea,oxygen saturation decrease,increased WBC count,decreased lymphocytes,and elevated CRP levels.More patients in the death group had complications such as ARDS,acute cardiac injury,acute kidney injury,shock,and DIC. | Yan Deng Wei Liu Kui Liu Yuan-Yuan Fang Jin Shang Ling Zhou Ke Wang Fan Leng Shuang Wei Lei Chen Hui-Guo Liu | 2020 | Chinese Medical Journal2020，，11： | 29 |
| 9 | Risk factors for intracranial aneurysm in a Chinese ethnic population显示文摘背景 Intracranial 动脉瘤( IAN )在一根大脑动脉上是一个耸出的水泡或囊汽球外面随着时间的过去,它可以导致自发的 subarachnoid 出血( SAH ),最终,残疾和 mortality.Current 研究显示疾病由于多重原因,包括环境因素和血容器的各种各样的先天的畸形。除了先天的倾向,象性别,年龄,高血压,和动脉粥样硬化那样的各种各样的高风险的因素涉及 intracranial 动脉瘤的形成。这研究的目的是调查在中国汉种族 patients.Methods 与分散的 intracranial 动脉瘤的形成联系的风险因素有 intracranial 动脉瘤的 251 个病人和有另外的服的疾病(控制组) 的 338 个病人的一个总数在这研究被注册。单个因素和逻辑回归模型被用来与年龄分析 intracranial 动脉瘤的协会;性别;香烟吸烟;酒精或可卡因消费;高血压,冠的动脉疾病,糖尿病 mellitus 和继承结缔组织疾病的历史;并且 fasting 血的层次葡萄糖和血脂肪。数据表示了同样吝啬的敤摡攠摮吗? | GU Yu-xiang CHEN Xian-cheng SONG Dong-lei LENG Bing ZHAO Fan | 2006 | Chinese Medical Journal2006，，16： | 28 |
| 10 | Direct Yaw Moment Control for Distributed Drive Electric Vehicle Handling Performance Improvement显示文摘For a distributed drive electric vehicle(DDEV) driven by four in-wheel motors, advanced vehicle dynamic control methods can be realized easily because motors can be controlled independently, quickly and precisely. And direct yaw-moment control(DYC) has been widely studied and applied to vehicle stability control. Good vehicle handling performance: quick yaw rate transient response, small overshoot, high steady yaw rate gain, etc, is required by drivers under normal conditions, which is less concerned, however. Based on the hierarchical control methodology, a novel control system using direct yaw moment control for improving handling performance of a distributed drive electric vehicle especially under normal driving conditions has been proposed. The upper-loop control system consists of two parts: a state feedback controller, which aims to realize the ideal transient response of yaw rate, with a vehicle sideslip angle observer; and a steering wheel angle feedforward controller designed to achieve a desired yaw rate steady gain. Under the restriction of the effect of poles and zeros in the closed-loop transfer function on the system response and the capacity of in-wheel motors, the integrated time and absolute error(ITAE) function is utilized as the cost function in the optimal control to calculate the ideal eigen frequency and damper coefficient of the system and obtain optimal feedback matrix and feedforward matrix. Simulations and experiments with a DDEV under multiple maneuvers are carried out and show the effectiveness of the proposed method: yaw rate rising time is reduced, steady yaw rate gain is increased, vehicle steering characteristic is close to neutral steer and drivers burdens are also reduced. The control system improves vehicle handling performance under normal conditions in both transient and steady response. State feedback control instead of model following control is introduced in the control system so that the sense of control intervention to drivers is relieved. | YU Zhuoping LENG Bo XIONG Lu FENG Yuan SHI Fenmiao | 2016 | Chinese Journal of Mechanical Engineering2016，29，3： | 28 |
| 11 | Effects of penehyclidine hydrochloride in small intestinal damage caused by limb ischemia-reperfusion显示文摘AIM:To investigate the protective effect of penehyclidine hydrochloride post-conditioning in the damage to the barrier function of the small intestinal mucosa caused by limb ischemia-reperfusion(LIR) injury. METHODS:Male Wistar rats were randomly divided into three groups(36 rats each) :the sham-operation group(group S) ,lower limb ischemia-reperfusion group(group LIR) ,and penehyclidine hydrochloride postconditioning group(group PHC) .Each group was divided into subgroups(n=6 in each group) according to ischemic-reperfusion time,i.e.immediately 0 h(T1) ,1 h(T2) ,3 h(T3) ,6 h(T4) ,12 h(T5) ,and 24 h(T6) .Bilateral hind-limb ischemia was induced by rubber band application proximal to the level of the greater trochanter for 3 h.In group PHC,0.15 mg/kg of penehyclidine hydrochloride was injected into the tail vein immediately after 3 h of bilateral hind-limb ischemia.The designated rats were sacrificed at different time-points of reperfusion;diamine oxidase(DAO) ,superoxide dismutase(SOD) activity,myeloperoxidase(MPO) of small intestinal tissue,plasma endotoxin,DAO,tumor necrosis factor-α(TNF-α) ,and interleukin(IL) -10 in serum were detected in the rats. RESULTS:The pathological changes in the small intestine were observed under light microscope.The levels of MPO,endotoxin,serum DAO,and IL-10 at T1-T6,and TNF-αlevel at T1-T4 increased in groups LIR and PHC(P<0.05) compared with those in group S,but tissue DAO and SOD activity at T1-T6 decreased(P<0.05) .In group PHC,the tissue DAO and SOD activity at T2-T6,and IL-10 at T2-T5 increased to higher levels than those in group LIR(P<0.05) ;however,the levels of MPO,endotoxin,and DAO in the blood at T2-T6,and TNF-αat T2 and T4 decreased(P<0.05) . CONCLUSION:Penehyclidine hydrochloride post-conditioning may reduce the permeability of the small intestines after LIR.Its protection mechanisms may be related to inhibiting oxygen free radicals and inflammatory cytokines for organ damage. | Yan Zhang Yu-Fang Leng Xing Xue Yue Zhang Tao Wang Yu-Qing Kang | 2011 | World Journal of Gastroenterology2011，17，2： | 25 |
| 12 | Diagnostic value of cancer-testis antigen mRNA in peripheral blood from hepatocellular carcinoma patients显示文摘AIM:To evaluate the diagnostic value of cancer-testis antigen(CTA) mRNA in peripheral blood samples from hepatocellular carcinoma(HCC) patients.METHODS:Peripheral blood samples were taken from 90 patients with HCC before operation.Expression of melanoma antigen-1(MAGE-1),synovial sarcoma X breakpoint-1(SSX-1),and cancer-testis-associated protein of 11 kDa(CTp11) mRNA in peripheral blood mononuclear cells(PBMC) was tested by nested reverse transcriptspolymerase chain reaction(RT-PCR).Serum α-fetoprotein(AFP) in these patients was also determined.RESULTS:The positive rate of MAGE-1,SSX-1 and CTp11 transcripts was 37.7%,34.4%,31.1% in PBMC samples,and 74.4%,73.3%,62.2% in their resected tumor samples,respectively.The positive rate for at least one of the transcripts of three CTA genes was 66.7% in PBMC samples and 91.1% in their resected tumor samples.MAGE-1,SSX-1 and/or CTp11 mRNA were not detected in the PBMC of those patients from whom the resected tumor samples were MAGE-1,SSX-1 and/or CTp11 mRNA negative,nor in the PBMC samples from 20 healthy donors and 10 cirrhotic patients.Among the 90 patients,the serum AFP in 44 patients met the general diagnostic standard(AFP > 400 μg/L) for HCC,and was negative(AFP ≤ 20 μg/L) or positive with a low concentration(20 μg/L < AFP ≤ 400 μg/L) in the other patients.The positive rate for at least one of the transcripts of three CTA genes in PBMC samples from the AFP negative or positive patients with a low concentration was 69.2% and 45.0%,respectively.Of the 90 patients,71(78.9%) were diagnosed as HCC by nested RT-PCR and serum AFP.Although the positive rate for at least one of the transcripts of three CTA genes in PBMC samples from 53 patients at TNM stage or was obviously higher than that in PBMC samples from 37 patients at stage or(77.9% vs 51.4%,P = 0.010),the CTA mRNA was detected in 41.7% and 56.0% of PBMC samples from HCC patients at stages andrespectively.CONCLUSION:Detecting MAGE-1,SSX-1 and CTp11 mRNA in PBMC improves the total diagnostic rate of HCC. | Li Zhao Dong-Cheng Mou Zeng-An Wu Ji-Run Peng Lei Huang Xi-Sheng Leng | 2010 | World Journal of Gastroenterology2010，16，32： | 22 |
| 13 | How to deal with cerebral palsy in 21^(st) century——A new epoch in clinic treatment显示文摘The aims of this paper were to define(1) criteria of cerebral palsy;(2) classification of cerebral palsy;(3) etiology,neuroimaging,and epidemiology of cerebral palsy;(4) different kinds of treatments of cerebral palsy.Data were drawn from an international survey of PUBMED(1994~2014) and CNKI(1994~2014).An expert panel used a consensus building technique.The10-point Jadad scale was used to assess the quality of the trials based on the following items,including allocation sequence generation,randomization concealment,methods of blinding,and descriptions of withdrawals and dropouts.Our clinical experience was also summarized.Below is a summary.(1) Further work is warranted to reach agreement for the classification of cerebral palsy.(2) A worldwide prevalence of 1.5~4.0 per 1 000 live births,with an average lifetime cost of 1 million dollars per person in the United States,while it is 1.8~6.0per 1 000 live births in China.(3) Comparison of clinical efficacy of different treatments.In this review,the current advances in different kind of treatments of brain injury are discussed with specific relevance to cerebral palsy. | Chun-yu TIAN Li-ge LENG Zeng-min TIAN | 2014 | 中国应用生理学杂志2014，30，6： | 22 |
| 14 | 北京协和医院临床老年医学发展经验显示文摘为了适应中国人口老龄化现状,打破以单器官为中心的传统诊疗模式,在中国推广现代老年医学理念,北京协和医院自2006年起与美国约翰.霍普金斯医学院开展老年医学合作项目。文章强调了在中国发展现代老年医学的重要性,并介绍了北京协和医院老年科的工作成果。以普通老年人为服务对象;老年综合评估成为入院病人的常规项目;建立了一支老年医学多学科整合团队,参与病房查房和门诊;开展了骨科的术前会诊和多重用药的管理等。最后,分析了中国老年医学发展所面临的问题。 | 刘晓红 沈悌 Leng Sean X | 2012 | 中国实用内科杂志2012，32，4： | 21 |
| 15 | 打破传统亚专科片段医疗服务模式引进现代老年医学观念显示文摘从分析老年患者群体的特殊性着手,引进现代老年医学以患者为中心的个体化医疗保健服务的理念,旨在打破以单个器官系统为中心的单病诊疗的传统亚专科片段医疗服务模式。基于这一核心理念,现代老年医学以满足患者与家属的医疗保健的需求为宗旨,强调整体性、系统性和连续性、多学科协作,以及功能和生活质量的评估、维护与康复。同时,我们也扼要介绍现代老年医学几种新型的医疗模式包括老年病房、髋部骨折专诊、亚急性和转诊医疗、全面的老年人服务项目以及退休养老社区连续性医疗保健服务。在美国中华医学基金会以及刚创建的米尔斯丁亚美医学基金会、米尔斯丁现代老年医学专项的大力支持下,在我们这个世界上最多的老年人口之国引进和发展现代老年医学,将对提高老年人的医疗照护能力有重要意义。 | Leng Sean X | 2012 | 中华老年医学杂志2012，31，1： | 21 |
| 16 | Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation显示文摘OBJECTIVE Psoriasis is an immune system meditated disease,especially T cells.It disturbed many people around the world and hard to therapy.Paeonia lactiflora Pall has been used as a medicine in china for thousands of years.Recent studies has found that the main component of Paeonia lactiflora Pall can alleviates the immune response in many diseases.In this study,we researched the effects and possible mechanisms of total glucosides of paeony(TGP)on animal psoriasis in order to study the therapeutic effects and mechanisms of TGP in 5%propranolol creaminduced psoriasis in guinea pigs and Imiquimod(IMQ)cream-induced psoriasis in mice.METHODS The effect of TGP was evaluated using a psoriasis-like model of guinea pigs and mice.Ear thickness was accessed,and pathology injury was observed by HE staining.The levels of serum IL-1β,IL-6,IL-12,IL-17,IL-23,TNF-α,and IFN-γ,skin IL-17A,IL-22 and orphan nuclear receptor(RORγt)mRNA expression,proliferating cell nuclear antigen(PCNA),total or phosphorylated signal transducers and activators of transcription(STAT1 and STAT3)were determined by ELISA,real time PCR,immu⁃nohistochemical staining,and Western blotting,respectively.RESULTS Compared with model group,TGP treatment decreased the ear thickness,improved pathology of psoriasis,alleviated IMQ-induced keratinocyte proliferation,reduced the inflammatory cytokine,and downregulated IL-17A,IL-22,and RORγt mRNA in mice.Further study indicated that TGP inhibited STAT1 and STAT3 phosphorylation in lesion skins of psoriasis-like mice.CONCLUSION TGP alleviates the symptoms of psoriasis-like guinea pigs and mice,and the possible mechanism may relate to inhibit T helper 17(TH17)cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation. | LI Bin-bin HE Shu-cheng LIU Rui HUANG Liang-liang LIU Ge WANG Rui-xuan YANG Zhuo-yue LIU Xin-yi LENG Ye LIU Dan YE Cheng-yu LI Yun-man CHEN Yong-jian IN Hong FANG Wei-rong | 2019 | 中国药理学与毒理学杂志2019，33，9： | 21 |
| 17 | Overexpression of cyclooxygenase-2 in human HepG2, Bel-7402 and SMMC-7721 hepatoma cell lines and mechanism of cyclooxygenase-2 selective inhibitor celecoxib-induced cell growth inhibition and apoptosis显示文摘AIM: To investigate the cyclooxygenase-2 (COX-2)expression level in human HepG2, Bel-7402 and SMMC-7721hepatoma cell lines and the molecular mechanism of COX-2 selective inhibitor celecoxib-induced cell growth inhibition and cell apoptosis.METHODS: Hepatoma cells were cultured and treated with celecoxib. Cell in situ hybridization (ISH) and immunocytochemistry were used to detect COX-2 mRNA and protein expression. Proliferating cell nuclear antigen and phosphorylated Akt were also detected by immunocytochemistry assay. Cell growth rates were assessed by 3-(4, 5-dimethylthiazol-2-yl-2, 5-diphenyltetrazolium (MTT) bromide colorimetric assay. Celecoxibinduced cell apoptosis was measured by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) and flow cytometry (FCM). The phosphorylated Akt and activated fragments of caspase-9, caspase-3 were examined by Western blotting analysis.RESULTS: Increased COX-2 mRNA and protein expression were detected in all three hepatoma cell lines. Celecoxib could significantly inhibit cell growth and the inhibitory effect was in a dose- and time-dependent manner evidenced by MTr assays and morphological changes.The apoptotic index measured by TUNEL increased correspondingly with the increased concentration of celecoxib and the reaction time. With 50 μmol/L celecoxib treatment for 24 h, the apoptotic index of HepG2, BEL-7402and SMMC-7721 cells was 25.01±3.08%, 26.40±3.05%,and 30.60±2.89%, respectively. Western blotting analysis showed remarkable activation of caspase-9, caspase-3and dephosphorylation of Akt (Thr308). Immunocytochemistry also showed the reduction of PCNA expression and phosphorylation Akt (Thr308) after treatment with celecoxib.CONCLUSION: COX-2 mRNA and protein overexpression in HepG2, Bel-7402 and SMMC-7721 cell lines correlate with the increased cell growth rate. Celecoxib can inhibit proliferation and induce apoptosis of hepatoma cell strains in a dose- and time-dependent manner. | Ning-Bo Liu Tao Peng Chao Pan Yu-Yu Yao Bo Shen Jing Leng | 2005 | World Journal of Gastroenterology2005，11，40： | 20 |
| 18 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 19 | Thermal energy storage:Challenges and the role of particle technology显示文摘Thermal energy is at the heart of the whole energy chain providing a main linkage between the primary and secondary energy sources.Thermal energy storage(TES)has a pivotal role to play in the energy chain and hence in future low carbon economy.However,a competitive TES technology requires a number of scientific and technological challenges to be addressed including TES materials,TES components and devices,and integration of TES devices with energy networks and associated dynamic optimization.This paper provides a perspective of TES technology with a focus on TES materials challenges using molten salts based phase change materials for medium and high temperature applications.Two key challenges for the molten salt based TES materials are chemical incompatibility and low thermal conductivity.The use of composite materials provides an avenue to meeting the challenges.Such composite materials consist of a phase change material,a structural supporting material,and a thermal conductivity enhancement material.The properties of the supporting material could determine the dispersion of the thermal conductivity enhancement material in the salt.A right combination of the salt,the structural supporting material,and the thermal conductivity enhancement material could give a hierarchical structure that is able to encapsulate the molten salt and give a substantial enhancement in the thermal conductivity.Understanding of the structure-property relationships for the composite is essential for the formulation design and fabrication of the composite materials.Linking materials properties to the system level performance is recommended as a key future direction of research. | Zhiwei Ge Yongliang Li Dacheng Li Ze Sun Yi Jin Chuanping Liu Chuan Li Guanghui Leng Yulong Ding | 2014 | Particuology2014，12，4： | 20 |
| 20 | Age-specific prevalence of human papillomavirus by grade of cervical cytology in Tibetan women显示文摘背景人的乳头状瘤病毒(HPV ) 被相信是最普通的性播送的感染。然而,很少在中国对 HPV 类型的流行和分发被知道。我们试图在居住在 China.Methods A 的西藏的自治区域的女人为反常颈的细胞学象风险一样估计流行和 HPV 类型的分发代表性的学习被执行包含 3036 个女人的一件样品。一张流行病学的问询表被使用,颈的标本为基于液体的细胞学和 HPV DNA 察觉被获得。统计分析在这张人口包括了 chi 平方和逻辑回归 model.Results,(111/3036 )3.66% 有未经决定的意义(子囊) 的不正常的有鳞的房间, 1.45%(44/3036 ) 低档有鳞的 intraepithelial 损害(LSIL ) 并且(33/3036 )1.09% 有高级有鳞的 intraepithelial 损害(HSIL ) 。西藏的女人(5.74% , 137/2387 ) 展出更低的反常细胞学比非西藏的女人评价(8.01% , 52/649, P=0.03 ) 。HPV 感染的全面流行是 9.19%(279/3036 ) 。我们没能到年龄在 HPV 流行识别任何差别。在有正常,子囊, LSIL 和 HSIL 的组,全面 HPV 流行是 7.41%(211/2847 ) , 24.32%(27/111 ) , 56.82%(25/44 ) 并且 45.45%(15/33 ) 分别地。HPV 16 (1.52%,46/3036 ) 是最普通的类型,并且在有子囊的女人也是最流行的(8.11% , 9/111 ) 并且 HSIL (15.15% , 5/33 ) 。为西藏的女人的最普通的 HPV 类型是 HPV 16 (1.42% , 34/2387 ) 而为非西藏的个人它是 HPV 33 (2.31% , 15/649 ) 。279 个感染 HPV 的女人, 40 个个人(14.34%) 与多重 HPV 确实介绍了。有二怀孕的女人是更可能的有反常细胞学油迹(OR=1.67; 95% CI:1.07-2.61 ).Conclusions HPV 确实的低流行在居住在中国的西藏的自治区域的女人被观察。反常颈的细胞学和 HPV 类型分布的流行在西藏、非西藏的女人之间是不同的。 | JIN Qiong SHEN Keng LI Hui ZHOU Xian-rong HUANG Hui-fang LENG Jin-hua | 2010 | Chinese Medical Journal2010，，15： | 19 |
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