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| 1 | Altered blood-brain barrier permeability in rats with prehepatic portal hypertension turns to normal when portal pressure is lowered显示文摘AIM: To study the blood-brain barrier integrity in prehe-patic portal hypertensive rats induced by partial portal vein ligation, at 14 and 40 d after ligation when portal pressure is spontaneously normalized. METHODS: Adult male Wistar rats were divided into four groups: GroupⅠ: Sham14d, sham operated; GroupⅡ: PH14d, portal vein stenosis; (both groups were used 14 days after surgery); GroupⅢ: Sham40d, Sham operated and GroupⅣ: PH40d Portal vein stenosis (GroupsⅡandⅣused 40 d after surgery). Plasma ammonia, plasma and cerebrospinal fluid protein and liver enzymes concentrations were determined. Trypan and Evans blue dyes, systemically injected, were investigated in hippocampus to study blood-brain barrier integrity. Portal pressure was periodically recorded. RESULTS: Forty days after stricture, portal pressure was normalized, plasma ammonia was moderately high, and both dyes were absent in central nervous system parenchyma. All other parameters were reestablished. When portal pressure was normalized and ammonia level was lowered, but not normal, the altered integrity of blood-brain barrier becomes reestablished. CONCLUSION: The impairment of blood-brain barrier and subsequent normalization could be a mechanism involved in hepatic encephalopathy reversibility, Hemo-dynamic changes and ammonia could trigger blood-brain barrier alterations and its reestablishment. | Francisco Eizayaga Camila Scorticati Juan P Prestifilippo Salvador Romay Maria A Fernandez José L Castro Abraham Lemberg Juan C Perazzo | 2006 | World Journal of Gastroenterology2006，12，9： | 3 |
| 2 | Obesity and the metabolic syndrome 显示文摘 | Keller KB Lemberg L | 2003 | Am J Crit Care2003，12，2： | 1 |
| 3 | Novel markers in the acute coronary syndrome: BNP, IL-6, PAPP-A显示文摘 | Futterman LG Lemberg L | 2002 | Am J Crit Care2002，11，2： | 1 |
| 4 | Fifty percent of patinets with coro- nary artery disease Do not have any of the conventional factors 显示文摘 | Futtennnan LG Lemberg L | 1998 | Am J Crit Care1998，7，3： | 1 |
| 5 | Prinzmetal's angina显示文摘 | Lemberg L | 2004 | Am J Crit Care2004，13，4： | 1 |
| 6 | Diffuse axonal injury:analysis of 100 patients wish radiological signs显示文摘 | Guiburd J N Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 7 | Gender differences in acute cordnary events显示文摘 | Keller K B Lemberg L | 2000 | Am J Crit Care2000，9，3： | 1 |
| 8 | Novel markers in the acute coronary syndrome:BNP,IL-6,PAPP-A-Cardiology Casebook显示文摘 | Futterman LG Lemberg L | 2002 | Am J Crit Care2002，11，2： | 1 |
| 9 | Novel makers in acute coronary syndrome: BNP, IL-6, PAPP-A显示文摘 | Futtermann LG Lemberg L | 2002 | Am J Crit Car2002，11，： | 1 |
| 10 | Fifty percent of patients with coronary artery disease do not have any of the conventional risk factors显示文摘 | Futtcrman LC Lemberg L | 1998 | Am J Critcare1998，7，3： | 1 |
| 11 | Diffuse axonal injury:analysis of 100 patients with radiological signs显示文摘 | Levi L Guilburd JN Lemberger A | 1990 | Neurosurgery1990，27，： | 1 |
| 12 | Fifty percent of patients with coronary artery diseasedo not have any of the conventional factors显示文摘 | Futterman LG Lemberg L | 1998 | Am J Crit Care1998，7，： | 1 |
| 13 | Diffuse axonal injury:Analysis of 100 patients with radiological signs显示文摘 | Levi L Guiburd J N Lemberger A | 1990 | Neurosurgery1990，27，3： | 1 |
| 14 | Novel markers in the acute coronary syndrome: BNP,IL-6, PAPP-A 显示文摘 | Futterman LG Lemberg L | 2002 | Am J Crit Care2002，11，2： | 1 |
| 15 | True view blade improves laryngeal view when compared to Macintosh blade显示文摘 | Lieberman N Hakim A R Lemberg L Berkenstadt H | 2003 | Anesthesiology2003，99，： | 1 |
| 16 | Peripartum Cardiomyopathy: an ominous complication of pregnancy显示文摘 | Futterman LG Lemberg L | 2000 | Am J Crit Care2000，9，5： | 1 |
| 17 | Novel markers in the acute coronary syndrome:BNP,IL-6,PAPP-A显示文摘 | Lemberg L | 2002 | Am J Crit Care2002，11，： | 1 |
| 18 | Obesity and the metabolic syndrome显示文摘 | Keller KB Lemberg L | 2003 | Am J Crit Care2003，12，2： | 1 |
| 19 | Statin pleiotropy: fact or fiction 显示文摘 | Futterman LG Lemberg L | 2004 | Am J Crit Care2004，13，24： | 1 |
| 20 | High-sensitivity C-reactive protein is the most effective prognostic measurement of acute coronary events显示文摘 | Futterman LG Lemberg L | 2002 | Am J Crit Care2002，11，5： | 1 |
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