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| 1 | Childhood stressful events, HPA axis and anxiety disorders显示文摘Anxiety disorders are among the most common of all mental disorders and their pathogenesis is a major topic in psychiatry, both for prevention and treatment. Early stressful life events and alterations of hypothalamic pituitary adrenal(HPA) axis function seem to have a significant role in the onset of anxiety. Existing data appear to support the mediating effect of the HPA axis between childhood traumata and posttraumatic stress disorder. Findings on the HPA axis activity at baseline and after stimuli in panic disordered patients are inconclusive, even if stressful life events may have a triggering function in the development of this disorder. Data on the relationship between stress, HPA axis functioning and obsessive-compulsive disorder(OCD) are scarce and discordant, but an increased activity of the HPA axis is reported in OCD patients. Moreover, normal basal cortisol levels and hyperresponsiveness of the adrenal cortex during a psychosocial stressor are observed in social phobics. Finally,abnormal HPA axis activity has also been observed in generalized anxiety disordered patients. While several hypothesis have attempted to explain these findings over time, currently the most widely accepted theory is that early stressful life events may provoke alterations of the stress response and thus of the HPA axis, that can endure during adulthood, predisposing individuals to develop psychopathology. All theories are reviewed and the authors conclude that childhood life events and HPA abnormalities may be specifically and transnosographically related to all anxiety disorders, as well as, more broadly, to all psychiatric disorders. | Carlo Faravelli Carolina Lo Sauro Lucia Godini Lorenzo Lelli Laura Benni Francesco Pietrini Lisa Lazzeretti Gabriela Alina Talamba Giulia Fioravanti Valdo Ricca | 2012 | World Journal of Psychiatry2012，2，1： | 3 |
| 2 | Ophthalmic cyclosporine use in ocular GVHD显示文摘 | Lelli GJ Jr Musch DC Gupta A | 2006 | Cornea2006，25，： | 1 |
| 3 | Obstructive ureterocele-an ongoing challenge显示文摘 | Merlini E Lelli CP | 2004 | World J Urol2004，22，： | 1 |
| 4 | The anabolic effect of high dose medroxy progesterone acetate in oncology 显示文摘 | Lelli G Angelelli B Giambias ME | 1983 | Pharmacol Res Commun1983，15，6： | 1 |
| 5 | Loss of susceptibility mutants of Arabidopsis thaliana reveal an essential role for eIF (iso) 4E during potyvirus infection显示文摘 | LELLIS A D KASSCHAU K D WHITHAM S A | 2002 | Curr Biol2002，12，： | 1 |
| 6 | The anabolic effect of high dose medroxyprogterone acetate in oncology显示文摘 | Lelli G Angelelli B Giambiasi Mg | 1983 | Ph-armacol Res Commun1983，15，6： | 1 |
| 7 | Chemorheologieal behavior of double-walled carbon nanotube-epoxy nanocomposites 显示文摘 | Terenzi A Vedova C Lelli G | 2008 | Composites Science and Technology2008，68，7： | 1 |
| 8 | Combined Three-dimensional Fluid Dynamic and Mechanical Modeling of Brush Seals显示文摘 | LELLI D CHEW J W COOPER P | | 0，，128： | 1 |
| 9 | Current considerations in the management of facial nerve palsy显示文摘 | Kim C Lelli GJ | 2013 | Curr Opin Ophthalmol2013，24，5： | 1 |
| 10 | ATP converts necrosis to apoptosis in oxidant-injured endothelial cells 显示文摘 | Lelli JL Jr Becks LL Dabrowska MI | 1998 | Free Radic Biol Med1998，25，6： | 1 |
| 11 | Genomic characterization of pseudorabies virus strains isolated in Italy显示文摘 | Sozzi E Moreno A Lelli D | 2014 | Transboundary Emerg Dis2014，61，4： | 1 |
| 12 | Lung resection in infants and children with pulmonary infections refractory to medical therapy显示文摘 | COWLES R A LELLI J L TAKAYASU J | 2002 | J Pediatr Surg2002，57，4： | 1 |
| 13 | Pigment dispersion and Artisan phakic intraocular lenses显示文摘 | Baikoff G Bourgeon G Jitsuo Jodai H Fortaine A Lellis FV Trinquet L | 2005 | J Cataract Refract Surg2005，28，6： | 1 |
| 14 | Neurotoxic activa- tion of microglia is promoted by a noxl-dependent NADPH oxidase显示文摘 | Ch6ret C Gervais A Lelli A | 2008 | J Neurosci2008，28，12： | 1 |
| 15 | ATP converts necrosis to apoptosis in oxidant-injured endothelial cells显示文摘 | Lelli JL Becks LL Dabrowska MI Hinshaw DB | 1998 | Free Radic Biol Med1998，25，6： | 1 |
| 16 | A new duplex real-time RT-PCR assay for sensitive and specific detection of African horse sickness virus显示文摘 | Monaco F Polci A Lelli R | 2011 | Molecular and Cellular Probes2011，25，23： | 1 |
| 17 | Cure Kinetics of Epoxy/an- hydride Nanocornposite Systems with Added Reactive Flame Retardants显示文摘 | Torre L Lelli G Kenny J M | 2004 | Journal of Applied Polymer Sci- ence2004，94，4： | 1 |
| 18 | experimental and com- putational study of cooling in simplified GM210 passenger compartment 显示文摘 | LIN C H LELLI M A HAN T | 1992 | SAE (society of automotive engi- neers)1992，2，2： | 1 |
| 19 | Isolation and characterization of microsatellite loci in Alasmidonta heterodon(Bivalvia:Unionidae)显示文摘 | Shaw KM King TL Lellis WA | 2006 | Molec Ecol Not2006，6，2： | 1 |
| 20 | Genomie characteriza- tion of pseudorabies virus strains isolated in Italy 显示文摘 | Sozzi E Moreno A Lelli D | 2014 | Transbound Emerg Dis2014，61，4： | 1 |
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