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| 1 | Pharmacological- and non-pharmacological therapeutic approaches in inflammatory bowel disease in adults显示文摘Inflammatory bowel diseases(IBDs) are a group of chronic inflammatory conditions mainly of the colon and small intestine. Crohn's disease(CD) and ulcerative colitis(UC) are the most frequent types of IBD. IBD is a complex disease which arises as a result of the interaction of environmental, genetic and immunological factors. It is increasingly thought that alterations of immunological reactions of the patients to their own enterable bacteria(microfilm) may contribute to inflammation. It is characterized by mucosal and sub mucosal inflammation, perpetuated by infiltration of activated leukocytes. CD may affect the whole gastrointestinal tract while UC only attacks the large intestine. The therapeutic goal is to achieve a steroidfree long lasting remission in both entities. UC has the possibility to be cured by a total colectomy, while CD never can be cured by any operation. A lifelong intake of drugs is mostly necessary and essential. Medical treatment of IBD has to be individualized to each patient and usually starts with anti-inflammatory drugs. The choice what kind of drugs and what route administered(oral, rectal, intravenous) depends on factors including the type, the localization, and severity of the patient's disease. IBD may require immune-suppression to control symptoms such as prednisolone, thiopurines, calcineurin or sometimes folic acid inhibitors or biologics like TNF-α inhibitors or anti-integrin antibodies. For both types of disease(CD, UC) the same drugs are available but they differ in their preference in efficacy between CD and UC as 5-aminosalicylic acid for UC or budesonide for ileocecal CD. As therapeutic alternative the main mediators of the disease, namely the activated pro-inflammatory cytokine producing leukocytes can be selectively removed via two apheresis systems(Adacolumn and Cellsorba) in steroid-refractory or dependent cases. Extracorporeal photopheresis results in an increase of regulatory B cells, regulatory CD8^+ T cells and T-regs Type 1. Both types of apheresis were able to induce clinical remission and mucosal healing accompanied by tapering of steroids. | Gerda C Leitner Harald Vogelsang | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 3 |
| 2 | High precision sampling for chromatographic separation显示文摘 | Barry E B Stuart P C Leitner J E | 1973 | Anal Chem1973，45，14： | 1 |
| 3 | Influence of heat treatment on the microstructure and toughness of Brohler M333 ISO- PLAST steel显示文摘 | Perko J Redl C Leitner H | 2009 | La Metallurgia haliana2009，，4： | 1 |
| 4 | Enhanced formation of extracellular laccase activity by the white-rot fungus Trametes multicolor 显示文摘 | HESS J LEITNER C GALHAUP C | 2002 | Appi Biochem Bioteehnol2002，100，19： | 1 |
| 5 | B7-H3 is a potent inhibitor of human T-cell activation: No evidence for B7-H3 and TREML2 interaction 显示文摘 | Leitner J Klauser C Pickl WF | 2009 | Eur J Immunol2009，39，7： | 1 |
| 6 | Influence of heat treatment on the microstructure and toughness of BOHLER M333 isoplast steel 显示文摘 | Perko J Redl C Leitner H | 2009 | la metallurgia italiana2009，4，： | 1 |
| 7 | Accurate reconstruction of a known HIV-1transmission history by phylogenetic tree analysis显示文摘 | Leitner T Escanilla D Franzen C | 1996 | Proceedings of the National Academy of Sciences of the United States of America1996，93，10： | 1 |
| 8 | Overview of the protein-protein interaction annotation extraction task of BioCreative II显示文摘 | Krallinger M Leitner F Rodfiguez-Penagos C | 2008 | Genome Biol(S1465-6906)2008，9，2： | 1 |
| 9 | IL-37:a new anti-inflammatory cytokine of the IL-1 fami-ly显示文摘 | Boraschi D Lucchesi D Hainzl S Leitner M Maier E Mangelberger D Oostingh GJ Pfaller T Pixner C PosseltG Italiani P Nold MF Nold-Petry CA Bufler P DinarelloCA | 2011 | Eur Cytokine Netw2011，22，3： | 1 |
| 10 | Purification and characterization of a laccase from the white-rot fungus Trametes multicolor显示文摘 | Leitner C Hess J Galhaup C | 2002 | Appl Biochem Biotechnol2002，，19： | 1 |
| 11 | Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia显示文摘 | Leitner J M Firbas C Mayr F B | | 0，，： | 1 |
| 12 | A skin homing molecule defines the langerhans cell progenitor in human peripheral blood显示文摘 | Strunk D Egger C Leitner G | 1997 | J Exp Med1997，185，6： | 1 |
| 13 | Treatment of extensive aseptic defects in old Achilles tendon ruptures:methods and case reports显示文摘 | Leitner A Voigt C Rahmanzadeh R | 1992 | Foot Ankle1992，13，： | 1 |
| 14 | B7-H3 is a potent inhibitor of human T-cell activation : No evidence for B7-H3 and TREML2 interac- tion显示文摘 | Leitner J Klauser C Pick1 WF | 2009 | Eur J Immunol2009，39，7： | 1 |
| 15 | Impact of ac- celerated ventricular tachyarrhythmias on mortality in pa- tients with implantable cardioverter-defibrillator therapy 显示文摘 | Schukro C Leitner L Siebermair J | 2013 | Int J Cardiol2013，167，6： | 1 |
| 16 | B7-H3 is a potent inhibi- tor of human T-cell activation :no evidence for B7-H3 and TREML2 interaction显示文摘 | Leitner J Klauser C Pickl WF | 2009 | European Journal of Immunology2009，39，7： | 1 |
| 17 | True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene 显示文摘 | Maier EM Leitner C Lohrs U Kuhnle U | 2003 | J Pediatr Endoerinol Metab2003，16，： | 1 |
| 18 | True hermaphroditism in an XY individual due to a familial point mutation of the SRY gene显示文摘 | Maier EM Leitner C Lohrs U | 2003 | J Pediatr Endocrinol Metab2003，16，4： | 1 |
| 19 | Left ventricular hypertrabeculation/noncompaction and neuromuselar disorders inidiopathic dilated cardiomyopathy 显示文摘 | STOLLBERGER C LEITNER S KOPSA W | 2004 | Acta Cardiol2004，59，4： | 1 |
| 20 | Accurate reconstruc tion of a known HIV-1 transmission history by phylogenetie tree analysis 显示文摘 | Leitner T Escanilla D Franzen C | 1996 | Proceedings of the National Academy of Sciences of the United States of America1996，93，10： | 1 |
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