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| 1 | Postpartum depression:A systematic review of the genetics involved显示文摘Postpartum depression is one of the most prevalent psychopathologies. Its prevalence is estimated to be between 10% and 15%. Despite its multifactorial etiology, it is known that genetics play an important role in the genesis of this disorder. This paper reviews epidemiological evidence supporting the role of genetics in postpartum depression(PPD). The main objectives of this review are to determine which genes and polymorphisms are associated with PPD and discuss how this association may occur. In addition, this paper explores whether these genes are somehow related to or even the same as those linked to Major Depression(MD). To identify gaps in the current knowledge that require investigation, a systematic review was conducted in the electronic databases Pub Med, LILACS and Sci ELO using the index terms 'postpartum depression' and 'genetics'. Literature searches for articles in peerreviewed journals were made until April 2014. PPD was indexed 56 times with genetics. The inclusion criteria were articles in Portuguese, Spanish or English that were available by institutional means or sent by authors upon request; this search resulted in 20 papers. Genes and polymorphisms traditionally related to MD, which are those involved in the serotonin, catecholamine, brain-derived neurotrophic factor and tryptophan metabolism, have been the most studied, and some have been related to PPD. The results are conflicting and some depend on epigenetics, which makes the data incipient. Further studies are required to determine the genes that are involved in PPD and establish the nature of the relationship between these genes and PPD. | Tiago Castro e Couto Mayra Yara Martins Brancaglion António Alvim-Soares Lafaiete Moreira Frederico Duarte Garcia Rodrigo Nicolato Humberto Corrêa Regina Amélia Lopes P Aguiar Henrique Vitor Leite | 2015 | World Journal of Psychiatry2015，5，1： | 5 |
| 2 | Optimizing outcomes for patients with gastric cancer peritoneal carcinomatosis显示文摘Peritoneal carcinomatosis (PC) from gastric cancer has traditionally been considered a terminal progression of the disease and is associated with poor survival out-comes. Positive peritoneal cytology similarly worsens the survival of patients with gastric cancer and treatment options for these patients have been limited. Recent ad-vances in multimodality treatment regimens have led to innovative ways to care for and treat patients with this disease burden. One of these advances has been to use neoadjuvant therapy to try and convert patients with positivecytologyorlow-volume PC to negative cytolo-gy with no evidence of active peritoneal disease.These strategies include the use of neoadjuvant systemic chemotherapy alone,using neoadjuvant laparoscopic heated intraper itoneal chemotherapy(NLHIPEC)after systemic chemotherapy,or using neoadjuvant intra-peritoneal and systemic chemother apy(NIPS)in a bi-dir ectional manner. For patients with higher volume PC,cytoreductive surgery (CRS) and hyperthermic intrape-ritoneal chemotherapy(HIPEC)have been mainstays of treatment. When used together, CRS and HIPEC can improve overall outcomes in properly selected patients,but overall survival outcomes remain unacceptably low.The extent of peritoneal disease, commonly measured by the peritoneal carcinomatosis index (PCI), and the com-pleteness of cytor eduction,has been shown to greatly impact outcomes in patients undergoing CRS and HIPEC.The uses of NLHIPEC and NLHIPEC plus NIPS have both been shown to decrease the PCI and thus increase the opportunity for complete cytoreduction. Newer therapies like pressurized intraperitoneal aerosol chemother apy and immunotherapy, such as catumaxomab, along with improved systemic chemotherapeutic regimens, are being explored with great interest.There is exciting progress being made in the management of PC from gastric can-cer and its’ treatment is no longer futile. | Jennifer L Leiting Travis E Grotz | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 4 |
| 3 | Neurophysiological basis of penile erection显示文摘阴茎勃起包含在中央 nervoussystem 之间的一个复杂相互作用,本地 factors.It 是调制由的一个神经与血管的事件心理并且氮的氧化物的 hormonalfactors.The 发现(没有)作为为识别生理的位于下面的重要机制和 pathophysiological eventsin 的一个细胞间的送信人或 neurotransmitter pavedthe 方法阴茎,除了提供,为新治疗学的发展的知识基于分子和房间相互作用的 ona | Fernanda B M PRIVIERO Romulo LEITE R Clinton WEBB Cleber E TEIXEIRA | 2007 | Acta Pharmacologica Sinica2007，28，6： | 3 |
| 4 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 5 | 显示文摘 | Sousa V C Leite E R Varela J A | 2002 | J Europ Ceram Soc2002，22，： | 1 |
| 6 | Microstructural and optical characterization of CaWO 4 and SrWO 4 thin films prepared by a chemical solution method显示文摘 | M.A.M.A Maurera A.G Souza L.E.B Soledade F.M Pontes E Longo E.R Leite J.A Varela | 2003 | Materials Letters2003，，5： | 1 |
| 7 | Timing of re- nal replacement therapy initiation by AKIN classification system显示文摘 | Leite T Macedo E Pereira SM | 2013 | Crit Care2013，17，2： | 1 |
| 8 | Particle growth during calcinations of polycation oxides synthesized by the polymeric precursors method 显示文摘 | Leite E R Nobre M A Cerqueira M | 1997 | J Am Ceram Soc1997，80，10： | 1 |
| 9 | Gen- otyping of Mycobacterium tuberculosis isolates from a low-endemic setting in northwestern state of Parana in Southern Brazil 显示文摘 | Noguti E N Leite C Q Malaspina AC | 2010 | Mem Inst Oswaldo Cruz2010，105，6： | 1 |
| 10 | Development of metal oxide nanoparticles with high stability against particle growth using a metastable solid solution 显示文摘 | Leite E R Maciel A P Weber I T | 2002 | Adv Mater2002，14，： | 1 |
| 11 | Hydrocracking of Phenanthrene over Pt/Si O2-Al2O3,Pt/H-Y,Pt/H-βand Pt/H-ZSM-5Catalysts:Reaction Pathway and Products Distribution显示文摘 | Benazzi E Leite L Marchal G N | 2000 | Stud Surf Sci Catal2000，130，： | 1 |
| 12 | Crystal growth in colloidal tin oxide nanocrystals induced by coalescence at room temperature显示文摘 | LEITE E R GIRALDI T R PONTERS F M | 2003 | Applied Physical Letter2003，83，8： | 1 |
| 13 | Expression of Correctly Processed Human Growth Hormone in Seeds of Transgenic Tobacco Plants显示文摘 | Leite A Kemper E | 2000 | Breeding2000，，6： | 1 |
| 14 | Nonlinear behavior of TiO2 - Ta2O5 - MnO2 material doped with BaO and Bi2O3 显示文摘 | Bomio M R D Sousa V C Leite E R | 2004 | Mater Chem Phys2004，85，： | 1 |
| 15 | Identifying a risk profile for thyroid cancer 显示文摘 | Ward L S Morari E C Leite J L | 2007 | Arq Bras Endocrinol Metabol2007，51，5： | 1 |
| 16 | Biosorption of copper by Paenibacillus polymyxa cells and their exopolysaccharide 显示文摘 | ACOSTA M P VALAMAN E LEITE S G F | 2005 | World Jouranal of Microbiology & Biotechnology2005，21，： | 1 |
| 17 | The effect of Ta2O5 and Cr2O3 on the electrical properties of TiO2 varistors显示文摘 | Sousa V C Leite E R Varela J A | 2002 | J Europ Ceram Soc2002，22，： | 1 |
| 18 | Sintering of ultrafine undoped SnO2 powder显示文摘 | LEITE E R CERRI J A LONGO E | 2001 | J Eur Ceram Soc2001，21，3： | 1 |
| 19 | Cerebrospinal fluid S100B increases reversibly in neonates of methyl mercury-intoxicated pregnant rats显示文摘 | Vicente E Boer M Leite M | 2004 | Neurotoxicology2004，25，5： | 1 |
| 20 | Supercapacitor electrodes obtained by directly bonding 2D MoS2 on reduced graphene oxide显示文摘 | Firmiano E G D S Rabelo A C Leite E R | 2014 | Adv Energy Mater2014，4，13： | 1 |
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