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| 1 | 抗结核药物肝毒性反应的危险因素及其影响显示文摘背景:肝毒性反应是抗结核药物(下简称ATD)最严重的不良反应之一。虽然已有许多关于肝毒性反应危险因素的报道,但关于肝毒性反应严重程度的影响尚无系统研究。目的:评估肝毒性反应的危险因素(包括高龄、慢性肝病、酗酒或滥用药物或营养不良)对ATD所致肝毒性反应严重性的影响。设计:对1998年1月至2002年7月期间在结核科门诊接受异烟肼、利福平、吡嗪酰胺治疗的471例活动性结核病人进行前瞻性队列分析。根据ATD所致肝毒性反应危险因素的暴露情况评价肝毒性反应的发生率及其严重性。结果:危险因素暴露组ATD所致肝毒性反应(血清转氨酶>3倍的正常上限值)的发生率为18.2%(42/231例),而对照组为5.8%(14/240例),(OR=3.5;95%CI:1.9-6.7;P<0.001)。暴露组的严重肝毒性反应(血清转氨酶>10倍的正常上限值)发生率为6.9%(16/231),而对照组为0.4%(1/240)(OR=17.7;95%CI:2.3-135;P<0.001)。结论:肝毒性反应危险因素暴露组病人的ATD所致肝炎显著多见且较为严重。 | A. Fernández-Villar B. Sopena J. Fernández-Villar R. Vázquez-Gallardo F. Ulloa V. Leiro M. Mosteiro L. Pineiro 马玙 | 2005 | 结核与肺部疾病杂志2005，8，1： | 13 |
| 2 | Fatigue of 0.55C-1.72Si Steel with Tempered Martensitic and Carbide-Free Bainitic Microstructures显示文摘High-Si spring steel was heat treated in three different ways:Quenching and tempering at 460 ℃ to obtain a tempered martensite microstructure,and austempering at 300 and 350 ℃,respectively,to obtain two different carbide-free bainitic microstructures.In the steel austempered at 350 ℃,both the bainite lath thickness and retained austenite content were higher than those of the steel austempered at 300 ℃.Rotating-bending fatigue tests were done in order to evaluate the effect of each heat treatment on the high-cycle fatigue behavior of the steel.When the austempering temperature was300 ℃,the endurance limit was increased by 25%despite a 5%reduction in tensile strength when compared with that of the quenched and tempered steel.The relationship between endurance limit[R_(fat)t(50%)]and ultimate tensile strength(R_m)was higher for the austempered samples in comparison with that of the quenched and tempered material.Therefore,it is believed that the presence of retained austenite affects the relationship between endurance limit and tensile strength. | Alejandro Leiro Arash Roshan Karl-Gustaf Sundin Esa Vuorinen Braham Prakash | 2014 | Acta Metallurgica Sinica(English Letters)2014，27，1： | 5 |
| 3 | Wear of nano-structured carbide-free bainitic steels under dry rolling–sliding conditions显示文摘 | A. Leiro E. Vuorinen K.G. Sundin B. Prakash T. Sourmail V. Smanio F.G. Caballero C. Garcia-Mateo Roberto Elvira | 2012 | Wear2012，，： | 2 |
| 4 | Infuenee of glutathione S transferase M1 and T1 homozy-gous null mutations on the riskofantituberculosis drug-induced hepatotoxieity in a Caucasian population显示文摘 | Virginia Leiro Alberto Fern andez-Villar Diana Valverde | 2008 | Liver Internation-al2008，28，6： | 1 |
| 5 | Defining the validity of a biochemical index of soil quality显示文摘 | LEIROS M C TRASAR-CEPEDA C GARCIA-FERNANDEZ F | 2002 | Biology and Fertility of Soils2002，30，1： | 1 |
| 6 | Expression profiles of genes in- volved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin显示文摘 | Leiro J Arranz JA Yanez M | 2004 | International Journal of Immunophar- macology2004，4，6： | 1 |
| 7 | Dependence of mineralization of soil organic matter on temperature and moisture显示文摘 | Leiros M C Trasar-Cepeda C Seoane S | 1999 | Soil Biology and Biochemistry1999，31，： | 1 |
| 8 | In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis facter-α and transforming growth factor-β genes 显示文摘 | Leiro M Alvarcz E Arranz J A | 2003 | Biochem Pharmacol2003，65，8： | 1 |
| 9 | Hair follicle stem cell differentiation is irohibited through cross-talk between Wnt/β -catenin and androgen signalling in dermal papilla cells from patients with androgenetic alopeciaa 显示文摘 | Leiros G J Attorresi AI Balana ME | 2012 | Br J Dermatol2012，166，5： | 1 |
| 10 | Structural and com- putational investigations of VIM-7: insights into the substrate specificity of VIM metallod3-1actamases显示文摘 | Borra P S Leiros H K Ahmad R | 2011 | J Mo[ Biol2011，411，1： | 1 |
| 11 | The antiinflammatory activity of the polyphenol resveratrol may be partially related to inhibition of tumour necrosis factor-α(TNF-α)pre-m RNA splicing显示文摘 | Leiro JM Varela M Piazzon MC | 2010 | Mol Immunol2010，47，： | 1 |
| 12 | Isolation and partial characterization of turbot immunoglobulins显示文摘 | Estevez J Leiro J Sanmartin M L | | 0，，： | 1 |
| 13 | Different approaches to evaluating soil quality using biochemical properties显示文摘 | Sotres F G Cepeda C T Leiros M C | 2005 | Soil Biology and Biochemistry2005，37，： | 1 |
| 14 | Effect of cis-resveratuol ongenes involved ni nuclear factor kappa B signaling 显示文摘 | Leiro J Arranz JA Fraiz N | 2005 | Int Innunophar- macol2005，5，2： | 1 |
| 15 | Different Approaches to Evaluating Soil Quality Using Biochemical Properties 显示文摘 | GIL-SOTRES F TRASAR-CEPEDA C LEIROS M C | 2005 | Soil Biology and Biochemistry2005，37，5： | 1 |
| 16 | Limitations of soil enzymes as indicators of soil pollution 显示文摘 | Trasar-cepeda C Leiros M C Seoane S | 2000 | Soil Biology & Biochemistry2000，，32： | 1 |
| 17 | Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling显示文摘 | Leiro J Arranz JA Fraiz N | 2005 | Int Immunopharmacol2005，5，2： | 1 |
| 18 | Dependence of mineralization of SOM on temperature and soil moisture 显示文摘 | LEIROS M C TRASAR-CEPEDA SEOANE | 1999 | Soil Biology and Biochemistry1999，31，3： | 1 |
| 19 | Metastatic cancer stem cells:new molecular targets for cancer therapy显示文摘 | LEIROS GJ BALAA ME | 2011 | Curr Pharm Biotechnol2011，12，11： | 1 |
| 20 | Limitations of soil enzymes as indicators of soil pollution显示文摘 | TRASAR-CEPEDA C LEIROS M C SEOANE S | 2000 | Soil Biology & Biochemistry2000，32，： | 1 |
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