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| 1 | Simple and sensitive determination of sparfloxacin in pharmaceuticals and biological samples by immunoassay显示文摘Plasma quinolone concentrations are not routinely measured in clinical practice.However,in order to optimize quinolone treatment,monitoring of plasma concentrations could sometimes be useful particularly in critically ill patients.In this study,anti-sparfloxacin antibody was obtained by immunizing rabbits with sparfloxacin conjugated with bovine serum albumin using isobutyl chloroformate method.After the assay procedure was optimized,the standard curve of sparfloxacin was established.The practical measuring range of the competitive ELISA extended from 5 ng/mL to 2 mg/mL.The recovery rates and coefficients of variation for rat plasma,urine and tissues were 87.7-106.2% and 4.8-15.3%,respectively.To demonstrate the potential of the ELISA,a preliminary pharmacokinetics and tissue distribution study of sparfloxacin in rats and quantitative analysis of sparfloxacin in several pharmaceuticals were performed and compared with high-performance liquid chromatography(HPLC).The experimental data indicated that the proposed method would be a valuable tool in therapeutic drug monitoring(TDM) for sparfloxacin. | Hua-Jin Zenga,Ran Yangb,Bing Liub,Li-Fang Leib,Jian-Jun Lib,Ling-Bo Qub,c,n aSchool of Pharmaceutical Sciences,Zhengzhou University,Zhengzhou 450001,China bDepartment of Chemistry,Zhengzhou University,Zhengzhou 450001,China cSchool of Chemistry & Chemical Engineering,Henan University of Technology,Zhengzhou 450001,China | 2012 | Journal of Pharmaceutical Analysis2012，2，3： | 2 |
| 2 | FCC regenerator flow model显示文摘 | SAPRE A V LEIB T M ANDERSON D H | 1990 | Chemical Engineering Science1990，45，8： | 1 |
| 3 | Fast prism: branch and bound hough transform for object class detection显示文摘 | Lehmann A Leibe B and Gool L | 2011 | International Journal of Computer Vision2011，94，2： | 1 |
| 4 | Efficient closed-form solution for target localization using TDOA measurements in the presence of sensor position errors显示文摘An efficient solution for locating a target was proposed, which by using time difference of arrival(TDOA) measurements in the presence of random sensor position errors to increase the accuracy of estimation. The cause of position estimation errors in two-stage weighted least squares(TSWLS) method is analyzed to develop a simple and effective method for improving the localization performance. Specifically, the reference sensor is selected again and the coordinate system is rotated according to preliminary estimated target position by using TSWLS method, and the final position estimation of the target is obtained by using weighted least squares(WLS). The proposed approach exhibits a closed-form and is as efficient as TSWLS method. Simulation results show that the proposed approach yields low estimation bias and improved robustness with increasing sensor position errors and thus can easily achieve the Cramer-Rao lower bound(CRLB) easily and effectively improve the localization accuracy. | Yan Leibing Zhang Yerong Lu Yin | 2017 | The Journal of China Universities of Posts and Telecommunications2017，24，4： | 1 |
| 5 | Biodegradation of Bisphenol A and other bisphenols by a gram-negative aerobic bacterium 显示文摘 | J H Lobos T K Leib T M Su | 1992 | Applied Environmental Microbiology1992，58，： | 1 |
| 6 | Inhibition of matrix metallo- proteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis 显示文摘 | Leib SL Clements J Leppert D | 2001 | Brain2001，124，9： | 1 |
| 7 | Biodegradation of bisphenol A and other bisphenols by a gram-negative aerobic bacterium显示文摘 | Lobos J H Leib T K Su T M | 1992 | Applied and Environmental Microbiology1992，58，6： | 1 |
| 8 | Tumor necrosis factor-α contributes to apoptosis in hippocampal neurons during experimental group B streptococcal meningitis显示文摘 | BOGDAN I LEIB SL BERGERON M | 1997 | J Infect Dis1997，176，： | 1 |
| 9 | Novel pathway for bac- terial metabolism of bisphenol A, rearrangements and stilbene cleavage in bisphenol A metabolism显示文摘 | Spivack J Leib T K Lobos J H | 1994 | Journal of Biological Chemistry1994，269，： | 1 |
| 10 | Micro APS based star tracker 显示文摘 | ALKALAI L DOMINGO G | 2002 | IEEE Proceedings of Aerospace Conference2002，，5： | 1 |
| 11 | Effects of low dose eorticosteroids on the bone mineral density of patients with rheumatoid arthritis显示文摘 | Buckley LM Leib ES Cartularo KS | 1995 | J Rheumatol1995，22，6： | 1 |
| 12 | Patient preference for light-cured composite bite splint compared to heat-cured acrylic bite splint 显示文摘 | Leib AM | 2001 | J Periodontol2001，72，8： | 1 |
| 13 | Maximizing SNR in improper complex noise and applications to CDMA显示文摘 | YOON Y C LEIB H | 1997 | IEEE Commun Lett1997，1，： | 1 |
| 14 | Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitis显示文摘 | Leib SL Clements JM Lindberg RL | | 0，，： | 1 |
| 15 | Robust object detection with interleaved categorization and segmentation 显示文摘 | Leibe B Leonardis A and Schiele B | 2008 | International Journal of Computer Vision Special Issue on Learning for Recognition and Recognition for Learning2008，77，1： | 1 |
| 16 | Official Positions of the International Society for Clinical Densitometry显示文摘 | Leib ES Michael LE | 2004 | South Med J2004，97，1： | 1 |
| 17 | Matrix metalloproteinases contribute to brain damage in experimental pneumococcal meningitis 显示文摘 | Leib SL Leppert D Clements J | 2000 | Infect Immun2000，68，： | 1 |
| 18 | Neuronal injury in experimental meningo-encephalitis due to Listeria monocytogenes:early apoptosis of neurons in the hippocampus显示文摘 | PFISTER LA LEIB SL MICHELET C TA' UBER MG | 1998 | Schweiz MedWochenschr1998，100，： | 1 |
| 19 | Identification of powdery mildew-induced barley genes by cDNA-AFLP:funetional assessment of an early expressed MAP kinase 显示文摘 | Eckey C Korell M Leib K | 2004 | Plant Mol Biol2004，55，1： | 1 |
| 20 | Resecting orbicularis oculi muscle in upper eyelid blepharoplasty-A review of the literature显示文摘 | HOORNTJEA E LEIB B V STOLLENWERCK G A | 2009 | J Plast Reconstr Aesthet Surg2009，10，： | 1 |
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