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| 1 | An epigenomic approach to therapy for tamoxifen-resistant breast cancer显示文摘Tamoxifen 是为雌激素受体 alpha 的前线治疗(ERα) 在绝经前的女人的积极的胸肿瘤。然而,到 tamoxifen 的抵抗发生在许多病人。嗯仍然与获得的 tamoxifen 抵抗在乳癌房间的生长起一个关键作用,建议那 ERα为治疗仍然是一个有效目标 tamoxifen 抵抗(Tam-R ) 乳癌。以识别 ERα 的新奇管理者;发信号,通过对 histone 甲基修饰词的一幅小规模的 siRNA 屏幕,我们发现了 WHSC1, histone H3K36 methyltransferase, ERα 的一个积极管理者;在乳癌房间发信号。我们证明 WHSC1 被招募到 ERα由 BET 蛋白质 BRD3/4 的基因,并且便于 ERα基因表示。小分子的赌注蛋白质禁止者 JQ1 potently 压制了经典 ERα发信号的小径和在文化的 Tam-R 乳癌房间的生长。用一个 Tam-R 乳癌异种皮移植老鼠模型,我们与 JQ1 和 ER degrader fulvestrant 由 JQ1 和联合治疗的强壮的长持续的效果在 vivo 反胸癌症活动示威了。一起拿,我们提供 epigenomic 蛋白质 BRD3/4 和 WHSC1 是雌激素受体发信号的必要管理者并且是为 Tam-R 乳癌的治疗的新奇治疗学的目标的证据。 | Qin Feng Zheng Zhang Martin J Shea Chad J Creighton Cristian Coarfa Susan G Hilsenbeck Rainer Lanz Bin He Lei Wang Xiaoyong Fu Agostina Nardone Yongcheng Song James Bradner Nicholas Mitsiades Constantine S Mitsiades C Kent Osborne Rachel Schiff Bert W O'Malley | 2014 | Cell Research2014，24，7： | 10 |
| 2 | Emergent Endoscopic Retrograde Cholangiopancreatography with Placement of Biliary Double Stents to Salvage Endoscopic Retrograde Cholangiopancreatography-lnduced Stapfer's Type Ⅱ Perforation显示文摘 | Ping Yue Wen-Bo Meng Joseph W Leung Lei Zhang Xiao-Liang Zhu Hui Zhang Hai-Ping Wang Zheng-Feng Wang Ke-Xiang Zhu Long Miao Wen-Ce Zhou Xun Li | 2018 | Chinese Medical Journal2018，，19： | 7 |
| 3 | A pair of transposon-derived proteins function in a histone acetyltransferase complex for active DNA demethylation显示文摘Transposons 被 epigenetic 机制通常包括 DNA methylation 使沉默。这里,我们识别了一双先驱导出 transposon 的蛋白质(HDP ) , HDP1 和 HDP2,在 Arabidopsis 的反沉默因素。hdp1 和 hdp2 异种显示了 transgenes 和某 transposons 的提高的 silencing。种系发生的分析表明 HDP1 和 HDP2 分别地从先驱编码 transposon 的 transposase 和 DNA 有约束力的蛋白质被共同驯养。HDP1 在原子核与 HDP2 交往,类似于他们的 transposon 对应物。而且, HDP1 和 HDP2 与组成在 DNA demethylation 工作的 histone acetyltransferase 建筑群的 IDM1, IDM2, IDM3 和 MBD7 被联系。HDP2 和 methyl-DNA-binding 蛋白质 MBD7 分享普通 genomic 绑定地点的一个大集合,显示他们联合决定 histone acetyltransferase 建筑群的目标特性。因此,我们的数据表明 HDP1 和 HDP2 组成被招募了到 histone acetyltransferase 建筑群阻止 DNA hypermethylation 和 epigenetic silencing 的一个功能的模块。 | Cheng-Guo Duan Xingang Wang Shaojun Xie Li Pan Daisuke Miki Kai Tang Chuan-Chih Hsu Mingguang Lei Yingli Zhong Yueh-Ju Hou ZhijuanWang Zhengjing Zhang Satendra K Mangrauthia Huawei Xu Heng Zhang Brian Dilkes W Andy Tao Jian-Kang Zhu | 2017 | Cell Research2017，27，2： | 6 |
| 4 | A review on MBE-grown HgCdSe infrared materials on GaSb(211)B substrates显示文摘We review our recent efforts on developing HgCdSe infrared materials on Ga Sb substrates via molecular beam epitaxy(MBE) for fabricating next generation infrared detectors with features of lower production cost and larger focal plane array format size. In order to achieve high-quality HgCdSe epilayers, ZnTe buffer layers are grown before growing HgCdSe, and the study of misfit strain in ZnTe buffer layers shows that the thickness of ZnTe buffer layer needs to be below 300 nm in order to minimize the generation of misfit dislocations. The cut-off wavelength/alloy composition of HgCdSe materials can be varied in a wide range by varying the ratio of Se/Cd beam equivalent pressure during the HgCdSe growth.Growth temperature presents significant impact on the material quality of HgCdSe, and lower growth temperature leads to higher material quality for HgCdSe. Typically, long-wave infrared HgCdSe(x = 0.18, cut-off wavelength of 10.4 μm at 80 K) presents an electron mobility as high as 1.3×10~5cm^2·V^(-1)·s^(-1), a background electron concentration as low as 1.6×10^(16)cm^(-3), and a minority carrier lifetime as long as 2.2 μs. These values of electron mobility and minority carrier lifetime represent a significant improvement on previous studies of MBE-grown HgCdSe reported in the open literatures,and are comparable to those of counterpart HgCdTe materials grown on lattice-matched CdZnTe substrates. These results indicate that HgCdSe grown at the University of Western Australia, especially long-wave infrared can meet the basic material quality requirements for making high performance infrared detectors although further effort is required to control the background electron concentration to below 10^(15)cm^(-3). More importantly, even higher quality HgCdSe materials on GaSb are expected by further optimizing the growth conditions, using higher purity Se source material, and implementing postgrowth thermal annealing and defect/impurity gettering/filtering. Our results demonstrate the great potential of HgCdSe infrared materials grown on GaSb substrates for fabricating next generation infrared detectors with features of lower cost and larger array format size. | Z K Zhang W W Pan J L Liu W Lei | 2019 | Chinese Physics B2019，28，1： | 2 |
| 5 | 鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大,以及低盐膳食模式与高血压的患病率和控制率相关显示文摘食物对高血压患病率和控制率的影响尚不清晰。本文旨在中国人群中调查鱼、蛋、牛奶、坚果、蔬菜和水果摄入量大以及低盐膳食模式是否与高血压有关。方法:从2012年9月到2014年12月共招募15303名受试者进行病例对照研究,分为高血压组(n=1604)和正常血压组(n=13660),其中高血压组又分为血压控制亚组(n=397)和血压未控制亚组(n=1207)。收集过去1 年里每周平均鱼、蛋、牛奶、坚果、蔬菜、水果和盐摄入量数据。鱼、蛋、牛奶、坚果、蔬菜、水果和盐的平均摄入量分别为117、150、35、20、2100、300和58g/周。 | Yu G Fu H Huang W Zhang N Deng D Li G Lei H | 2019 | 中华高血压杂志2019，27，5： | 2 |
| 6 | P450 BM3:the very model of a modern flavocytochrome 显示文摘 | MUNRO A W LEYS D G MCLEAN K J | 2002 | Trends Biochem Sci2002，27，5： | 1 |
| 7 | QoS-aware routing based on bandwidth estimation for mobile ad hoc networks显示文摘 | Chen Lei Heinzelman W | 2005 | IEEE Journal on Selected Areas in Communications2005，23，3： | 1 |
| 8 | Bradycardia induces angiogenesis, increases coronary reserve, and preserves function in postinfarcted heart显示文摘 | LEI L ZHENG W TOMANEK R J | 2004 | Circulation2004，110，7： | 1 |
| 9 | Accuracy enhancement of five-axis CNC machines through real-time error compensation显示文摘 | Lei W T Hsu Y Y | 2003 | International Journal of Machine Tools and Manufacture2003，43，9： | 1 |
| 10 | Solubilization and mineralization of polycyclic aromatic hydrocarbons by Pseudomonas putida in the presence of surfactant 显示文摘 | Doong R Lei W | 2003 | Journal of hazardous materials2003，96，1： | 1 |
| 11 | Corrosion evaluation of microarc oxidation coatings formed on 2024 aluminium alloy 显示文摘 | Lei W Wang Y M Zhou Y | 2010 | Corrosion Science2010，52，8： | 1 |
| 12 | TGF-betal-induced migration of bonemesenchymal stem cells couples bone resorption with formation显示文摘 | Tang Y Wu X Lei W | 2009 | Nat Med2009，15，： | 1 |
| 13 | QSAR study on N-containing corrosion inhibitors:Quantum chemical approach assisted by topological index显示文摘 | S G Zhang W Lei M Z Xia | 2005 | Journal of Molecular Structure:THEOCHEM2005，732，： | 1 |
| 14 | Hydrothermal Fabrication of Hierarchically Anatase TiO2Nanowire arrays on FTO Glass for Dye-sensitized Solar Cells显示文摘 | WU W Q LEI B X RAO H S | 2013 | Sci Rep2013，3，： | 1 |
| 15 | Synthetic applications of photoredox catalysis with visible light显示文摘 | Xi Y M Yi H Lei A W | 2013 | Org Biomol Chem2013，11，： | 1 |
| 16 | Interracial structure and performance of rubber/boehmite nanocomposites modified by methacrylic acid显示文摘 | Chen W W Wu S W Lei Y D | 2011 | Polymer2011，52，19： | 1 |
| 17 | Measuring Olympics achievementsbased on a parallel DEA approach显示文摘 | LEI X Y L1 Y J XIE X W | 2015 | Ann Operat Res2015，226，1： | 1 |
| 18 | 显示文摘 | Lei Y Chim W K | 2005 | Chem Mater2005，17，3： | 1 |
| 19 | Synchronization of two chaotic nonlinear gyros using active control 显示文摘 | Lei Y Xu W Zheng H | 2005 | Phys Lett A2005，343，13： | 1 |
| 20 | Performance of long rectangular barrettes in granitic saprolites 显示文摘 | Ng C W W Lei G H | 2003 | Journal of Geotechnical and Geoenvironmental Engineering America Society of Civil Engineers2003，129，8： | 1 |
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