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| 1 | m^6A mRNA methylation sustains Treg suppressive functions显示文摘 | Jiyu Tong Guangchao Cao Ting Zhang Esen Sefik Maria Carolina Amezcua Vesely James P Broughton Shu Zhu Huabin Li Bin Li Lei Chen Howard Y Chang Bing Su Richard A Flavell Hua-Bing Li | 2018 | Cell Research2018，28，2： | 30 |
| 2 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 3 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 4 | Preparation and hybridization analysis of DNA/RNA from E. coli on microfabricated bioelectronic chips显示文摘 | Cheng Jing Sheldon E L Wu Lei Uribe A Gerrue L O Carrino J Heller M J O'Connell J P | | 0，，： | 2 |
| 5 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 6 | Finite element analysis and design in stainless steel sheet forming and its experimental comparison显示文摘 | Lei L P Hwang S M Kang B S | 2001 | Journal of Materials Processing Technology2001，110，1： | 2 |
| 7 | Degradation of dye pollutants by immobilized polyoxometalate with H2O2 under visible-light irradiation显示文摘 | Lei P X Chen C C Yang J el al | 2005 | Environmental Science and Technology2005，39，21： | 1 |
| 8 | High concentrations of sVCAM-1 and slCAM-1 in the cerebrospinal fluid of patients with intracerebral haemorrhage are associated with poor outcome显示文摘 | Kraus J Oschmann P Leis S | 2002 | J Neurol Neurosurg Psychiatry2002，73，3： | 1 |
| 9 | DNA self-recognition in the structure of Potl bound to telomeric single-stranded DNA显示文摘 | Lei M Podell E R Baumann P | 2003 | Nature2003，426，6963： | 1 |
| 10 | A class of nonlinear degenerate integrodifferential vontrol systems显示文摘 | Gao H Lei P D Zhing B | 2004 | SIAM J Control Optim2004，43，： | 1 |
| 11 | The role of carotid ar- tery stenting and carotid endarterectomy in cognitive per- formance a systematic review显示文摘 | De Rango P Caso V Leys D | 2008 | Stroke2008，39，11： | 1 |
| 12 | Interactive effects of southern rice black- streaked dwarf virus infection of host plant and vector on performance of the vector, Sogatella furcifera (Homoptera: Delphacidae) 显示文摘 | Lei WB Liu DF Li P | 2014 | Economic Entomology2014，107，5： | 1 |
| 13 | Analysis and Design of Hydroforming Process for Automobile Rear Axle Housing by FEM显示文摘 | LEI L P KIMJ KANG B S | 2000 | Machine Tools Manuf2000，40，12： | 1 |
| 14 | The Production of Level Fast Dyeings on Wool with Nucleophilic Dyes and a Crosslinking Agent显示文摘 | Lewis D M Wang Y N | 1992 | JSDC1992，108，9： | 1 |
| 15 | Beneficial effects of fructose1,6-diphosphateo hemorrhagic shock in rats显示文摘 | Wang P Lei Z | 1999 | Chin J Traumatol1999，2，1： | 1 |
| 16 | Conducting polyaniline-coated silica nanoparticles by in situ chemical oxidative grafting polymerization显示文摘 | Lei X P Su Z X | 2007 | Polym Adv Techn2007，18，： | 1 |
| 17 | Fascial planes and compartment of posterior abdomen显示文摘 | Lei QF Marks SC Jr Touliopoulos P | 1990 | Clin Anat1990，3，1： | 1 |
| 18 | A New Curve Detection Method:Randomized Hough Transform(RHT)显示文摘 | Lei Xu Oja E Kultanen P | 1990 | Pattern Recognition Letters1990，11，5： | 1 |
| 19 | Municipal wastes and their solar transformities: An emergy synthesis for Macao显示文摘 | Lei K P Wang Z S | 2008 | Waste Management2008，28，12： | 1 |
| 20 | 100 nm period gratings produced by lithographically induced self-construction 显示文摘 | LEI X Y WU L DESHPANDE P | 2003 | Nanoteehnology2003，14，7： | 1 |
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