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| 1 | 男性迟发性性腺功能减退症的检查、治疗和监测:国际男科学会(ISA)、国际老年男性研究会(ISSAM)、欧洲泌尿外科学会(EAU)、欧洲泌尿外科学院(EAA)和美国男科学会(ASA)联合推荐显示文摘简介
人口学资料明确显示:老年人口占总人口的百分率正逐年增加。当前,有关老年男性雄激素缺乏的问题逐渐成为令人感兴趣、但又充满争议的世界性话题。已经有横向和纵向的研究资料表明,随着年龄增大,成年男子的雄激素水平逐渐降低, | Wang C Nieschlage E Swerdloff R Behre HM Hellstrom WJ Gooren LJ Kaufman JM Legros JJ Lunenfeld B Morales A Morley JE Schulman C Thompson IM Weidner W Wu FCW 伍学焱(翻译) | 2011 | 国际生殖健康/计划生育杂志2011，30，1： | 8 |
| 2 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 3 | A patient's guide: polycystic ovary syndrome(PCOS)显示文摘 | Hoeger K M Legro R S Welt C K | 2014 | J Clin Endocrinol Metab2014，99，1： | 1 |
| 4 | Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance 显示文摘 | VGONTZAS A N LEGRO R S BIXLER E O | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 5 | Enhancing pyrene mineralization in contaminated soil by the addition of humic acids or composted contaminated soil 显示文摘 | HADERLEIN A LEGROS R and RAMSAY B | 2001 | Applied Microbiology and Biotechnology2001，56，： | 1 |
| 6 | Detecting insulin resistance in polycystic ovary syndrome: purposes and pitfalls显示文摘 | LEGRO R S CASTRACANE V D KAUFFMAN R P | 2004 | Obstetrical and Gynecological Survey2004，59，2： | 1 |
| 7 | Polycystic ovary syndrome 显示文摘 | Norman R J Dewailly D Legro RS | 2007 | Lancet2007，370，9588： | 1 |
| 8 | Adolescent girls with polycystic ovary syndrome have an increased risk of the met- abolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance显示文摘 | Coviello A D Legro R S Dunaif A | 2006 | J Clin En- docrinol Metab2006，91，： | 1 |
| 9 | Polycystic ovary syndrome显示文摘 | Norman R J Dewailly D Legro R S | 2007 | Lancet2007，，370： | 1 |
| 10 | Insulin resistance in the sisters of women with polycystic ovary syndrome: association with hyperandrogenemia rather than menstrual irregularity显示文摘 | Legro RS Bentley-Lewis R Driscoll D | 2002 | J Clin Endocrinol Metab2002，87，： | 1 |
| 11 | Clomiphene, mefformin, or both for infertility in the polycystic ovarysyndrome 显示文摘 | Legro R S Bamhart H X Schlaff W D | 2007 | N Engl J Med2007，356，6： | 1 |
| 12 | Types of H2O in human enamel and in precipitated apatites显示文摘 | Legeros R Z Bonel G Legros R | 1978 | Calcified Tissue Research1978，26，2： | 1 |
| 13 | Multifactoral analysis of p53 alteration in human cancer: a review 显示文摘 | Soussi T Legros Y Lubin R etal | 1994 | Int J Cancer1994，57，： | 1 |
| 14 | Detecting insulin resistance in polycystic ovary syndrome:Purposes and pitfalls显示文摘 | Legro R S Castracane V D Kauffman R P | 2004 | Obstet Gynecol Surv2004，59，2： | 1 |
| 15 | Troglitazone improves ovulation and hirsutism in the polycystic ovary syndrome: a multicenter,double blind, placebo-controlled trial 显示文摘 | Azziz R Erhmann D Legro RS | 2001 | J Clin Endocrinol Metab2001，86，： | 1 |
| 16 | Multifactorial analysis of p53 alteration in human cancer: a review显示文摘 | Soussi T Legros Y Lubin R | 1994 | Int J Cancer1994，57，1： | 1 |
| 17 | Troglitazone decreases adre- nal androgen levels in women with polycystic ovary syndrome 显示文摘 | Azziz R Ehrmann DA Legro RS | 2003 | Fertil Steri12003，79，： | 1 |
| 18 | The effects of a whole grain enriched hypocaloric diet on cardiovascular disease risk factors in men and women with metabolic syndromel 显示文摘 | Katcher H I Legro R S Kunselman A R | 2008 | Am J 'Clin Nutr2008，87，1： | 1 |
| 19 | Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective , controlled study in 254 affected women显示文摘 | Legro R L Kumselman A R Dodson W C | 1999 | J Clin Endocrinol Metab1999，84，： | 1 |
| 20 | Enhancing pyrene mineralization in contaminated soil by the addition of humic acids or composted contaminated soil显示文摘 | HADERLEIN A LEGROS R RAMSAY B | 2001 | Appl Microbiol Biotechnol2001，56，34： | 1 |
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