|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | RhD表型阴性分子机制的研究显示文摘 | 邵超鹏 Tobias J. Legler | 2003 | 中华医学杂志2003，83，10： | 10 |
| 2 | Exposure to endocrine disrupting chemicals perturbs lipid metabolism and circadian rhythms显示文摘A growing body of evidence indicates that exposure to environmental chemicals can contribute to the etiology of obesity by inappropriately stimulating adipogenesis as well as perturbing lipid metabolism and energy balance. One potential mechanism by which chemical exposure can influence lipid metabolism is through disturbance of circadian rhythms, endogenously-driven cycles of roughly 24 hr in length that coordinate biochemical, physiological, and behavioral processes in all organisms. Here we show for the first time that exposure to endocrine disrupting compounds(EDCs), including the pesticide tributyltin, two commercial flame retardants, and a UV-filter chemical found in sunscreens,can perturb both circadian clocks and lipid metabolism in vertebrates. Exposure of developing zebrafish to EDCs affects core clock activity and leads to a remarkable increase in lipid accumulation that is reminiscent of the effects observed for longdaysin, a known disruptor of circadian rhythms. Our data reveal a novel obesogenic mechanism of action for environmental chemicals, an observation which warrants further research. Because circadian clocks regulate a wide variety of physiological processes, identification of environmental chemicals capable of perturbing these systems may provide important insights into the development of environmentally-induced metabolic disease. | Renate Kopp Irene Ozáez Martínez Jessica Legradi Juliette Legler | 2017 | Journal of Environmental Sciences2017，29，12： | 4 |
| 3 | SeaWinds validation with research vessels显示文摘 | BOURASSA M A LEGLER D M O'BRIEN J J | 2003 | J Geophys Res2003，108，2： | 1 |
| 4 | The chemo- kine SIC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7显示文摘 | Willimann K Legler DF Loetscher M | 1998 | Eur J Immunol1998，28，6： | 1 |
| 5 | Brain and other central nervous system cancers: recent trends in incidence and mortality 显示文摘 | Legler JM Ries LA Smith MA | 1999 | J Nail Cancer Inst1999，91，23： | 1 |
| 6 | Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays显示文摘 | LEGLER DENNEKAMP VETHAAK | 2002 | The Science of the Total Environment2002，293，： | 1 |
| 7 | RHD suqueneing:a new tool for decision making on transfusion therapy and provision of Rh prophylaxis 显示文摘 | Legler TJ Mass JH Kohler M | 2001 | Trausfus Med2001，11，5： | 1 |
| 8 | Impact of resting heart rate on ~utcomes in hypertensive patients with coronary artery disease: findings from the International Verapamil-SR/trandolapril Study ( INVEST ) 显示文摘 | Kolloch R Legler UF Champion A | 2008 | Eur Heart J2008，29，10： | 1 |
| 9 | Anti- D in pregnant women with the RHD(IVS3 + 1G > A) - associated DEL phenotype显示文摘 | Gardener GJ Legler TJ Hyett JA | 2012 | Transfusion2012，52，9： | 1 |
| 10 | Dynamics of ascospore maturation and discharge in Erysiphe necator, the causal a- gent of grape powdery mildew 显示文摘 | ROSSI V CAFFI T LEGLER S E | 2010 | Phytopathology2010，100，12： | 1 |
| 11 | Ponsin interacts with Nck adapter proteins:implications for a role in cytoskeletal remodelling during differentiation of skeletal muscle cells显示文摘 | Gehmlich K Hayess K Legler C | 2010 | Eur J Cell Biol2010，89，5： | 1 |
| 12 | RHD genotyping in weak D phenotypes by multiple polymerase chain reactions 显示文摘 | Legler T J Maas J H Blaschke V | 1998 | Transfusion1998，38，5： | 1 |
| 13 | Molecular and serologic characterization of DWI, a novel 'high-grade' partial D 显示文摘 | Kormoczi GF Legler TJ Daniels GL | 2004 | Transfusion2004，44，4： | 1 |
| 14 | Fluidized bed processing in the nuclear fuel cycle显示文摘 | Legler B M | 1970 | Chemical Engineering Progress Symposium Series1970，66，105： | 1 |
| 15 | RESPONSE:re:brain and other central nervous system cancers:recent trends in incidence and mortality显示文摘 | Legler J M GloecklerRies L A Smith M A | 2000 | J Natl Cancer Inst2000，92，1： | 1 |
| 16 | Molecular mechanisms of RhD negative phenotype显示文摘 | SHAO Chao-Peng Legler TJ | 2003 | Natl Med J China2003，83，10： | 1 |
| 17 | Recruitment of TNF receptor 1 to lipid rafts is essential for TNFа-mediated NF-kB activation显示文摘 | Legler DF Micheau O Doneey M | 2003 | Immunity2003，18，5： | 1 |
| 18 | Posterior continuous curvilinear capsulorhexis;an experimental study with clinical ap- plications 显示文摘 | Castaneda VE Legler UFC Tsa JC | 2012 | Ophthalmology2012，99，： | 1 |
| 19 | Fetal DNA : strategies for optimal recovery 显示文摘 | Legler TJ Heermann KH Liu Z | 2008 | Methods Mol Biol2008，444，： | 1 |
| 20 | Differential cross sections of atomic Au for electron scattering (30-200 eV)显示文摘 | S HOLST W LEGLER R NEWJOTO | 1990 | J Phys B:At Mol Opt Phys1990，，23： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员