|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord显示文摘Despite numerous efforts to overcome neuropathic pain,various pharmacological drugs often fail to meet the needs and have many side effects.Muscovite is an aluminosilicate mineral that has been reported to have an anti-inflammatory effect,but the efficacy of muscovite for neuropathic pain has not been investigated.Here,we assessed whether muscovite nanoparticles can reduce the symptoms of pain by controlling the inflammatory process observed in neuropathic pain.The analgesic effects of muscovite nanoparticles were explored using partial sciatic nerve ligation model of neuropathic pain,in which one-third to onehalf of the nerve trifurcation of the sciatic nerve was tightly tied to the dorsal side.Muscovite nanoparticles(4 mg/100μL)was given intramuscularly to evaluate its effects on neuropathic pain(3 days per week for 4 weeks).The results showed that the muscovite nanoparticle injections significantly alleviated partial sciatic nerve ligation-induced mechanical and cold allodynia.In the spinal cord,the muscovite nanoparticle injections exhibited inhibitory effects on astrocyte and microglia activation and reduced the expression of pro-inflammatory cytokines,such as interleukin-1β,tumor necrosis factor-α,interleiukin-6 and monocyte chemoattractant protein-1,which were upregulated in the partial sciatic nerve ligation model.Moreover,the muscovite nanoparticle injections resulted in a decrease in activating transcription factor 3,a neuronal injury marker,in the sciatic nerve.These results suggest that the analgesic effects of muscovite nanoparticle on partial sciatic nerve ligation-induced neuropathic pain may result from inhibiting activation of astrocytes and microglia as well as pro-inflammatory cytokines.We propose that muscovite nanoparticle is a potential anti-nociceptive candidate for neuropathic pain.All experimental protocols in this study were approved by the Institutional Animal Ethics Committee(IACUC)at Dongguk University,South Korea(approval No.2017-022-1)on September 28,2017. | Ju-Young Oh Tae-Yeon Hwang Jae-Hwan Jang Ji-Yeun Park Yeonhee Ryu HyeJung Lee Hi-Joon Park | 2020 | Neural Regeneration Research2020，15，11： | 7 |
| 2 | Development of DNA Chip for the Simultaneous Detection of Various beta-Lactam Antibiotic-resistant Genes显示文摘 | Yeonhee Lee Choong-Sik Lee Yeo-Jung Kim | 2002 | Mol Cells2002，14，： | 1 |
| 3 | Towards scalable internet traffic measurement and analysis with Hadoop 显示文摘 | Lee Yeonhee Lee Youngseok | 2013 | ACM SIGCOMM Computer Communication Review2013，43，1： | 1 |
| 4 | Improvement of adhesion properties for Cu films on the polyimide by plasma source ion implantation显示文摘 | Ju Hi Hong Yeonhee Lee Seunghee Han | 2006 | Surface : Coatings Technology2006，201，： | 1 |
| 5 | Application of micro-attenuated total reflectance FTIR spectroscopy in the forensic study of questioned documents involving red seal inks显示文摘 | Warnadi Dirwono Jin Sook Park M.R. Agustin-Camacho Jiyeon Kim Hyun-Mee Park Yeonhee Lee Kang-Bong Lee | 2010 | Forensic Science International2010，，1： | 1 |
| 6 | Improvemet of hydrophobic properties of polymer surfaces by plasma source ion implantation 显示文摘 | KIM Youngsoo LEE Yeonhee HAN Seunghee | 2006 | Surface & Coating Technology2006，200，： | 1 |
| 7 | Toward scalable internet traffic measurement and analysis with hadoop 显示文摘 | Lee Yeonhee Lee Youngseok | 2013 | ACM SIGCOMM Computer Communication Review2013，43，1： | 1 |
| 8 | Toward Scalable Internet Traffic Meas- urement and Analysis with Hadoop 显示文摘 | Yeonhee Lee Youngseok Lee | 2013 | ACM SIGCOMIM Computer Communication Review2013，43，1： | 1 |
| 9 | Identification of secondary metabolites with antioxidant and antimicrobial activities from Artemisia iwayomogi and Chrysanthemum zawadskii显示文摘 | Seungwon Shin Yeonhee Lee Su Ran Moon | 2010 | Biochemical Journal2010，53，6： | 1 |
| 10 | Controlled drug delivery systems: the next 30 years显示文摘再考的药交货科学家需要在过去的 60 年期间献殷勤的,分析我们的当前的能力,和图案将推进的未来技术我们完成药交货技术的下一水平。历史证明药交货研究的第一代(1G ) 在 19501980 期间是相当高效的,当在 19802010 期间开发的第二种产生(2G ) 技术不是同样丰富的时。药交货研究的最终的目标是开发临床上有用的明确的表达治疗各种各样的疾病。有效的药交货系统能被克服明确的表达障碍或生物障碍开发。设计途径在解决这个问题有限制,如果生物困难清楚地没被识别并且理解。第三个产生(3G ) 药交货系统将不得不集中于理解生物障碍以便他们能被设计药交货系统的操作克服。下一 30 年里的进展将被没有任何预想的想法,在药交货技术上开始开的对话最加速。药交货科学家的新一代需要知道存在技术的成功和限制以后为有意义的进展设计新技术。 | Yeonhee YUN Byung Kook LEE Kinam PARK | 2014 | Frontiers of Chemical Science and Engineering2014，8，3： | 0 |
| 11 | Analgesic efficacy of median nerve stimulation in mice with chemotherapy-induced peripheral neuropathy via modulation of brain-derived neurotrophic factor expression显示文摘OBJECTIVE:Chemotherapeutic agents such as docetaxel(DTX)can trigger chemotherapy-induced peripheral neuropathy(CIPN),which is characterized by unbearable pain.This study was designed to investigate the analgesic effect and related neuronal mechanism of low-frequency median nerve stimulation(LFMNS)on DTX-induced tactile hypersensitivity in mice.METHODS:To produce CIPN,DTX was administered intraperitoneally 4 times,once every 2 d,to male ICR mice.LFMNS was performed on the wrist area,and the pain response was measured using von Frey filaments on both hind paws.Western blot and immunofluorescence staining were performed using dorsal root ganglion and spinal cord samples to measure the expression of brainderived neurotrophic factor(BDNF).RESULTS:Repeated LFMNS significantly attenuated the DTX-induced abnormal sensory response and suppressed the enhanced expression of BDNF in the DRG neurons and spinal dorsal area.CONCLUSIONS:LFMNS might be an effective nonpharmaceutical option for treating patients suffering from CIPN via regulating the expression of peripheral and central BDNF. | Dong-Wook Kang Jae-Gyun Choi Hee Ju Song Jaehyuk Kim Miae Lee Taehee Kim Suk-Yun Kang Yeonhee Ryu Hwa Seung Yoo Jin Sun Lee Jin Bong Park Sang Do Lee Hyun-Woo Kim | 2023 | Journal of Traditional Chinese Medicine2023，43，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员