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| 1 | 体外冲击波治疗烧伤瘢痕增生的前瞻性随机双盲研究显示文摘该研究旨在探讨体外冲击波治疗对增生性瘢痕再生的影响作者将48例移植中厚皮片修复创面的烧伤患者随机分为治疗组(25例)和对照组(23例)2组患者创面愈合后均接受常规康复治疗,其中治疗组另加以0.05~03O mJ/mm^(2)的低能流密度冲击波治疗,每周1次。 | 茹天峰(编译) 谢卫国(审校) Lee SY Joo SY Cho YS | 2021 | 中华烧伤杂志2021，37，4： | 8 |
| 2 | 药用植物内生菌对作物生长及氧化应激的作用(英文)显示文摘目的:探讨药用植物内生菌的多样性及其在种子生长和氧化应激中的作用。方法:从三种药用植物(Caralluma acutangula、Rhazya stricta和Moringa peregrina)中提取内生菌;基于18S r DNA测序和系统发育分析鉴定分离得到的内生菌株;以正常和矮化突变体水稻品系为对照,比较不同浓度的内生菌培养滤液(CF)对水稻种子的发芽和生长的影响;通过气相色谱-质谱分析CF中的有效活性成分。结论:从药用植物中共获得10种内生菌,包括茎点霉属6株、链格孢属2株、双极霉属1株和枝孢霉属1株。CF表现出剂量依赖性的生长刺激和抑制作用。与对照和其他内生菌相比,100%的茎点霉菌CF显著促进了水稻种子的发芽和生长;双极霉中的吲哚乙酸含量最高,并表现出比其更高的自由基清除和抗脂质过氧化活性;双极霉菌和茎点霉菌的类黄酮和酚类成分较高。综上所述,药用植物中存在内生菌株,其可以用于改善作物生长和减轻氧化应激。 | Abdul Latif KHAN Syed Abdullah GILANI Muhammad WAQAS Khadija AL-HOSNI Salima AL-KHIZIRI Yoon-Ha KIM Liaqat ALI Sang-Mo KANG Sajjad ASAF Raheem SHAHZAD Javid HUSSAIN In-Jung LEE Ahmed AL-HARRASI | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，2： | 6 |
| 3 | Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays显示文摘AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as 'cases'. Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as 'controls'. Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates < 90% for autosomal single nucleotide polymorphisms (SNPs) were excluded. For each precancerous lesion, associated SNPs were identified from Manhattan plots, and only SNPs with a χ2 P value < 0.05 and Hardy Weinberg Equilibrium P value > 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in 'cases' vs 'controls' for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials. | Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan Syed Hassan Syed Abdul Aziz Noorizan Abdul Majid Bin Alwi Zilfalil | 2013 | World Journal of Gastroenterology2013，19，23： | 5 |
| 4 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 5 | 大肠杆菌的高密度培养显示文摘大肠杆菌是最广泛用于异源性蛋白合成的原核系统.最适表达系统一旦构建成功,通过增加每单位时间每个菌体的蛋白产量(单位生产率),或通过增加每单位时间的菌体浓度(菌体生产率)而使蛋白产量增加.已开发出在加料分批培养中培养重组与非重组大肠杆菌株达每升100g(菌体干重)以上收量的各种高细胞密度培养(HCDC)技术.本文综述了大肠杆菌HCDC所遇到的问题,讨论了不同的解决办法.还介绍了大肠杆菌HCDC的加料策略及使用这些策略所得到的结果. | Lee SY 王剑虹 | 1997 | 国外医学(预防.诊断.治疗用生物制品分册)1997，20，2： | 4 |
| 6 | High surface area and mesoporous activated carbon from KOH-activated dragon fruit peels for methylene blue dye adsorption:Optimization and mechanism study显示文摘In this study,an alternative precursor for production of activated carbon was introduced using dragon fruit(Hylocereus costaricensis)peel(DFP).Moreover,KOH was used as a chemical activator in the thermal carbonization process to convert DFP into activated carbon(DFPAC).In order to accomplish this research,several approaches were employed to examine the elemental composition,surface properties,amorphous and crystalline nature,essential active group,and surface morphology of the DFPAC.The BrunauerEmmettTeller test demonstrated a mesoporous structure of the DFPAC has a high surface area of 756.3 m2g 1.The cationic dye Methylene Blue(MB)was used as a probe to assess the efficiency of DFPAC towards the removal of MB dye from aqueous solution.The effects of adsorption input factors(e.g.DFPAC dose(A:0.040.12 g L 1),pH(B:310),and temperature(C:3050℃))were investigated and optimized using statistical analysis(i.e.BoxBehnken design(BBD)).The adsorption kinetic model can be best categorized as the pseudofirst order(PFO).Whereas,the adsorption isotherm model can be best described by Langmuir model,with maximum adsorption capacity of DFPAC for MB dye was 195.2 mg g 1 at 50℃.The adsorption mechanism of MB by DFPAC surface was attributed to the electrostatic interaction,pp interaction,and Hbonding.Finally,the results support the ability of DFP to be a promising precursor for production of highly porous activated carbon suitable for removal of cationic dyes(e.g.MB). | Ali H.Jawad Ahmed Saud Abdulhameed Lee D.Wilson Syed Shatir A.Syed-Hassan Zeid A.ALOthman Mohammad Rizwan Khan | 2021 | Chinese Journal of Chemical Engineering2021，34，4： | 3 |
| 7 | 男性C反应蛋白、纤维蛋白原和心肺适应性与高血压发生风险的相关性显示文摘在正常血压和高血压高危人群中,较高的心肺适应性(cardiorespiratory fitness)可预防高血压[1-2]。但高心肺适应性能否降低炎症水平升高的受试者发生高血压的风险,尚不清楚。本研究旨在探讨男性中,独立于肥胖,炎症与高血压发生的相关性;心肺适应性、炎症与高血压发生的联合相关性。研究者假设炎症与高血压发生相关,但高心肺适应性可降低这种相关性。 | Jae SY Kurl S Laukkanen JA Lee CD Choi YH Fernhall B Franklin BA | 2015 | 中华高血压杂志2015，23，9： | 2 |
| 8 | A regulatory role for TRAF1 in antigen-induced apoptosis of T cells 显示文摘 | Speiser DE Lee SY Wong B | 1997 | J Exp Med1997，185，10： | 2 |
| 9 | The course of patients with lacunar infarcts and a parent arterial lesion similarities to large artery vs small artery disease显示文摘 | Bang OY Joo SY Lee PH | | 0，，： | 2 |
| 10 | Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas 显示文摘 | Soung YH Lee JW Kim SY | 2005 | Virchows Arch2005，446，5： | 1 |
| 11 | Ectonic expression of interleukin-1 receptor type Ⅱ enhances cell migration through activation of the pre-interleukin 1 alpha pathway显示文摘 | Chang SY Su PF Lee TC | 2009 | Cytokine2009，45，1： | 1 |
| 12 | Binding aspects of baicalein to HIV-1 integrase显示文摘 | Ahn HC Lee SY Kim JW | 2001 | Mol Cells2001，12，1： | 1 |
| 13 | HLA-B27 subtypes in Korean patients with ankylosing spondylitis显示文摘 | Park KS Kang SY Lee WI | 2008 | Korean J Lab Med2008，28，1： | 1 |
| 14 | Predictors of incident diabetes, metabolic syndrome in middle- aged adults: a 10 -year follow- up study from Kinmen, Taiwan 显示文摘 | Sheu WH Chuang SY Lee WJ | 2006 | Diabetes Research and Clinical Practice2006，45，1： | 1 |
| 15 | Correlaton of cervical carcionma and precancerous lesions with human papillomavirus(HPV) genetypes detected with the HPV DNA chip microarray mithod显示文摘 | An HJ Cho NH Lee SY | 2003 | Cancer2003，97，7： | 1 |
| 16 | The effects of polymorphisms in methylenetetrahydrofolate reductase ( MTHFR ) , methionine synthase (MTR) , and methionine synthase reductase ( MTRR ) on the risk of cervical intraepithelial neoplasia and cervical cancer in Korean women 显示文摘 | Tong SY Lee JM Song ES | 2010 | Cancer Causes Control2010，21，1： | 1 |
| 17 | The Nuss procedure for pectus excavatum:Evolution of techniques and early results on 322 patients显示文摘 | Park HJ Lee SY Lee CS | 2004 | Ann Thorac Surg2004，77，1： | 1 |
| 18 | Homogeneous chitosan-PLGA compile fibrous scaffolds for tissue regeration显示文摘 | Shim IK Lee SY Park YJ | 2008 | J Biomed Mater Res A2008，84，1： | 1 |
| 19 | Case-deletion measures for models with incomplete data显示文摘 | Zhu HT Lee SY Wei BC Zhu J | 2001 | Biometrika2001，88，： | 1 |
| 20 | p21WAF1 is involved in inter feron-β- induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression in ovarian cancer 显示文摘 | Lee JH Lee SY Lee JH et ol | 2010 | Mol Cells2010，30，4： | 1 |
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