|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Clinical implication of 14-3-3 epsilon expression in gastric cancer显示文摘AIM:To evaluate for the first time the protein and mRNA expression of 14-3-3εin gastric carcinogenesis.METHODS:14-3-3εprotein expression was determined by western blotting,and mRNA expression was examined by real-time quantitative RT-PCR in gastric tumors and their matched non-neoplastic gastric tissue samples.RESULTS:Authors observed a significant reduction of 14-3-3εprotein expression in gastric cancer(GC)samples compared to their matched non-neoplastic tissue.Reduced levels of 14-3-3εwere also associated with diffuse-type GC and early-onset of this pathology.Our data suggest that reduced 14-3-3εmay have a role in gastric carcinogenesis process.CONCLUSION:Our results reveal that the reduced 14-3-3εexpression in GC and investigation of 14-3-3ε interaction partners may help to elucidate the carcino-genesis process. | Mariana Ferreira Leal Danielle Queiroz Calcagno Smia Demachki Paulo Pimentel Assumpo Roger Chammas Rommel Rodríguez Burbano Marília de Arruda Cardoso Smith | 2012 | World Journal of Gastroenterology2012，18，13： | 6 |
| 2 | rate of adverse events of gastroduodenal snare polypectomy for non-flat polyp is low: A prospective and multicenter study显示文摘AIM To evaluate the rate of adverse events(AEs) during consecutive gastric and duodenal polypectomies in several Spanish centers. METHODS Polypectomies of protruded gastric or duodenal polyps ≥ 5 mm using hot snare were prospectively included. Prophylactic measures of hemorrhage were allowed in predefined cases. AEs were defined and graded according to the lexicon recommended by the American Society for Gastrointestinal Endoscopy. Patients were followed for 48 h, one week and 1 mo after theprocedure. RESULTS308 patients were included and a single polypectomy was performed in 205. Only 36(11.7%) were on prior anticoagulant therapy. Mean polyp size was 15 ± 8.9 mm(5-60) and in 294 cases(95.4%) were located in the stomach. Hemorrhage prophylaxis was performed in 219(71.1%) patients. Nine patients presented AEs(2.9%), and 6 of them were bleeding(n = 6, 1.9%)(in 5 out of 6 AE, different types of endoscopic treatment were performed). Other 24 hemorrhagic episodes could be managed without any change in the outcome of the endoscopy and, consequently, were considered incidents. We did not find any independent risk factor of bleeding.CONCLUSION Gastroduodenal polypectomy using prophylactic measures has a rate of AEs small enough to consider this procedure a safe and effective method for polyp resection independently of the polyp size and location. | Henry Córdova Lidia Argüello Carme Loras Antonio Naranjo Rodríguez Faust Riu Pons Joan B Gornals David Nicolás-Pérez Xavier Andújar Murcia Luis Hernández Santos Santolaria Carles Leal Carles Pons Enrique Pérez-Cuadrado-Robles Orlando García-Bosch Michel Papo Berger José Luis Ulla Rocha Cristina Sánchez-Montes Gloria Fernández-Esparrach | 2017 | World Journal of Gastroenterology2017，23，47： | 3 |
| 3 | Serum proinflammatory cytokines and nutritional status in pediatric chronic liver disease显示文摘AIM: To evaluate the nutritional status and its association with proinflammatory cytokines in children with chronic liver disease.METHODS: We performed a cross-sectional study with 43 children and adolescents, aged 0 to 17 years, diagnosed with chronic liver disease. All patients regularly attended the Pediatric Hepatology Unit and were under nutritional follow up. The exclusion criteria were fever from any etiology at the time of enrollment, inborn errors of the metabolism and any chronic illness. The severity of liver disease was assessed by Child-Pugh, Model for End-stage Liver Disease(MELD) and Pediatric End Stage Liver Disease(PELD) scores. Anthropometric parameters were height/age, body mass index/age and triceps skinfold/age according to World Health Organization standards. The cutoff points for nutritional status were risk of malnutrition(Z-score <-1.00) and malnutrition(Z-score <-2.00). Interleukin-1β(IL-1β), IL-6 and tumor necrosis factor-α levels were assessed by commercial ELISA kits. For multivariate analysis, linear regression was applied to assess the association between cytokine levels, disease severity and nutritional status. RESULTS: The median(25th-75 th centile) age of the study population was 60(17-116)-mo-old, and 53.5% were female. Biliary atresia was the main cause of chronic liver disease(72%). With respect to Child-Pugh score, cirrhotic patients were distributed as follows: 57.1% Child-Pugh A, a mild presentation of the disease, 34.3% Child-Pugh B, a moderate stage of cirrhosis and 8.6% Child-Pugh C, were considered severe cases. PELD and MELD scores were only above the cutoff point in 5 cases. IL-6 values were increased in patients at nutritional risk(34.9%) compared with those who were well-nourished [7.12(0.58-34.23) pg/m L vs 1.63(0.53-3.43) pg/m L; P = 0.02], correlating inversely with triceps skinfold-for-age z-score(rs =-0.61; P < 0.001). IL-6 levels were associated with liver disease severity assessed by Child-Pugh score(P = 0.001). This association remained significant after adjusting for nutritional status in a linear regression model. CONCLUSION: High IL-6 levels were found in children with chronic liver disease at nutritional risk. Inflammatory activity may be related to nutritional status deterioration in these patients. | Daniele Santetti Maria Inês de Albuquerque Wilasco Cristina Toscani Leal Dornelles Isabel Cristina Ribas Werlang Fernanda Urruth Fontella Carlos Oscar Kieling Jorge Luiz dos Santos Sandra Maria Goncalves Vieira Helena Ayako Sueno Goldani | 2015 | World Journal of Gastroenterology2015，21，29： | 2 |
| 4 | Neutrophile-to-lymphocyte,lymphocyte-to-monocyte,and platelet-tolymphocyte ratios as prognostic and response biomarkers for resectable locally advanced gastric cancer显示文摘BACKGROUND Perioperative fluorouracil plus leucovorin,oxaliplatin,and docetaxel(FLOT)improves prognosis in locally advanced gastric cancer(LAGC).Neutrophil-to-lymphocyte(NLR),lymphocyte-tomonocyte(LMR),and platelet-to-lymphocyte(PLR)ratios are prognostic biomarkers but not predictive factors.AIM To assess blood ratios’(NLR,LMR and PLR)potential predictive response to FLOT and survival outcomes in resectable LAGC patients.METHODS This was a multicentric retrospective study investigating the clinical potential of NLR,LMR,and PLR in resectable LAGC patients,treated with at least one preoperative FLOT cycle,from 12 Portuguese hospitals.Means were compared through non-parametric Mann-Whitney tests.Receiver operating characteristic curve analysis defined the cut-off values as:High PLR>141 for progression and>144 for mortality;high LMR>3.56 for T stage regression(TSR).Poisson and Cox regression models the calculated relative risks/hazard ratios,using NLR,pathologic complete response,TSR,and tumor regression grade(TRG)as independent variables,and overall survival(OS)as the dependent variable.RESULTS This study included 295 patients(mean age,63.7 years;59.7% males).NLR was correlated with survival time(r=0.143,P=0.014).PLR was associated with systemic progression during FLOT(P=0.022)and mortality(P=0.013),with high PLR patients having a 2.2-times higher risk of progression[95% confidence interval(CI):0.89-5.26]and 1.5-times higher risk of mortality(95%CI:0.92-2.55).LMR was associated with TSR,and high LMR patients had a 1.4-times higher risk of achieving TSR(95%CI:1.01-1.99).OS benefit was found with TSR(P=0.015)and partial/complete TRG(P<0.001).Patients without TSR and with no evidence of pathological response had 2.1-times(95%CI:1.14-3.96)and 2.8-times(95%CI:1.6-5)higher risk of death.CONCLUSION Higher NLR is correlated with longer survival time.High LMR patients have a higher risk of decreasing T stage,whereas high PLR patients have higher odds of progressing under FLOT and dying.Patients with TSR and a pathological response have better OS and lower risk of dying. | Tiago Cruz Tomás Ines Eiriz Marina Vitorino Rodrigo Vicente Joao Gramaca Alicia Guadalupe Oliveira Paulo Luz Mafalda Baleiras Ana Sofia Spencer Luísa Leal Costa Patrícia Liu Joana Mendonca Magno Dinis Teresa Padrao Marisol Correia Goncalo Atalaia Michelle Silva Teresa Fiúza | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 2 |
| 5 | Influence of formula- tion on propofol pharmacokineties and pharmacodynam ics in anesthetized patients显示文摘 | Calvo R Telletxea S Leal N et a l | 2004 | Acta Anaesthesiol Scand2004，48，8： | 1 |
| 6 | Pheromone study of Acarid mites, -acaridal,the sex pheromone of the Acarid mites Caloglyphus polyphyllae显示文摘 | Leal W S Kuwahara Y Suzuki T | 1989 | Naturwissenschaften1989，，76： | 1 |
| 7 | Olfactory receptor neu rons detecting plant odours and male volatiles in Anomala cu prea beetles (Coleoptera: Searabaeidae) 显示文摘 | Lasson M C Leal W S Hansson B S | 2001 | Journal of Insect Physiology2001，47，： | 1 |
| 8 | Photodynamic therapy disinfection of carious tissue mediated by aluminum - chloride- phthalocyanine entrapped in cationic liposomes: an in vitro and clinical study 显示文摘 | Longo J P F Leal S C Simioni A'R | 2012 | Lasers Med Sci2012，27，： | 1 |
| 9 | Living Donor Liver Transplantation for Acute Liver Failure: A Single Center Experience显示文摘 | L.P. Cariús L.F. Pacheco-Moreira E. Balbi C.R.G. Leal A.C. Gonzalez L.V. Agoglia C. Araújo M. Enne J.M. Martinho | 2009 | Transplantation Proceedings2009，，3： | 1 |
| 10 | DNA testing for hypertrophic cardiomyopathy:a cost-effectiveness model显示文摘 | Wordsworth S Leal J Blair E | | 0，，8： | 1 |
| 11 | Kairomone from dan-delion, Taraxacum officinale, attraetant for scarab beetle Anornala octiescostata 显示文摘 | Leal W S Ono M Hasegawa M | 1994 | Journal of Chemical Ecology1994，20，7： | 1 |
| 12 | Unusual periodicity of sex pheromone production in the large black chafer Holotrichia paraUela显示文摘 | Leal W S Sawada M Matsuyarna S | 1993 | Journal of Chemical Ecology1993，19，： | 1 |
| 13 | Activation of neutrophils by autocrine IL-17A-IL-17RC interactions during fungal infection is regulated by IL-6,IL-23,RORγt and dectin-2显示文摘 | Taylor PR Roy S Leal SM Jr | 2014 | Nat Immunol2014，15，： | 1 |
| 14 | Unusual periodicity of sex pheromone production in the large black chafer Ho lotrichia Darallela显示文摘 | Leal W S Sawada M Matsuyama S | 1993 | J Chem Ecol1993，19，： | 1 |
| 15 | Identification and cloning of odorant binding proteins from the scarab beetle Phyllopertha diversa显示文摘 | Wojtasek H Picimbon J F Leal W S | 1999 | Biochemical and Biophysical Research Communications1999，263，： | 1 |
| 16 | Female sex pheromone of the longhorn beetle Migdolus fryanus Westwood: N- ( 2' S ) - methylbutanoyl 2-methylbutlyamine 显示文摘 | Leal W S Bento J M S Vilela E F | 1994 | Experientia1994，50，： | 1 |
| 17 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | MEO S C LEAL C L GARCIA J M | 2004 | Anim Reprod Sci2004，81，： | 1 |
| 18 | Kinetics and molecular properties of pheromone binding and release显示文摘 | Leal W S Chen A M Ishida Y | 2005 | Proceeding of National Academy of Sciences of the USA2005，102，： | 1 |
| 19 | Unusual periodicity of sex pheromone production in the large black chafer Holotrichia par- aUela 显示文摘 | Leal W S Sawada M Matsuyama S | 1993 | Journal of Chemical Ecology1993，19，7： | 1 |
| 20 | Caries experience in a child population in a deprived area of Brazil, using ICDAS II显示文摘 | de Amorim R Figneiredo M Leal S | 2012 | Clin Oral Investig2012，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员