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| 1 | Role of mi RNAs and their potential to be useful as diagnostic and prognostic biomarkers in gastric cancer显示文摘Alterations in epigenetic control of gene expression play an important role in many diseases, including gastric cancer. Many studies have identified a large number of upregulated oncogenic mi RNAs and downregulated tumour-suppressor mi RNAs in this type of cancer. In this review, we provide an overview of the role of mi RNAs, pointing to their potential to be useful as diagnostic and/or prognostic biomarkers in gastric cancer. Moreover, we discuss the influence of polymorphisms and epigenetic modifications on mi RNA activity. | Kelly Cristina da Silva Oliveira Taíssa Maíra Thomaz Araújo Camila Inagaki Albuquerque Gabriela Alcantara Barata Carolina Oliveira Gigek Mariana Ferreira Leal Fernanda Wisnieski Fernando Augusto Rodrigues Mello Junior André Salim Khayat Paulo Pimentel de Assumpcao Rommel Mário Rodriguez Burbano Marília Cardoso Smith Danielle Queiroz Calcagno | 2016 | World Journal of Gastroenterology2016，22，35： | 11 |
| 2 | Interrelationship between chromosome 8 aneuploidy,C-MYC amplification and increased expression in individuals from northern Brazil with gastric adenocarcinoma显示文摘AIM: To investigate chromosome 8 numerical aberra- tions, C-MYC oncogene alterations and its expression in gastric cancer and to correlate these findings with histo- pathological characteristics of gastric tumors. METHODS: Specimens were collected surgically from seven patients with gastric adenocarcinomas. Immu- nostaining for C-MYC and dual-color fluorescence in situ hybridization (FISH) for C-MYC gene and chromosome 8 centromere were performed. RESULTS: All the cases showed chromosome 8 aneu- ploidy and C-MYC amplification, in both the diffuse and intestinal histopathological types of Lauren. No significant difference (P < 0.05) was observed between the level ofchromosome 8 ploidy and the site, stage or histological type of the adenocarcinomas. C-MYC high amplification, like homogeneously stained regions (HSRs) and double minutes (DMs), was observed only in the intestinal-type. Structural rearrangement of C-MYC, like translocation, was observed only in the diffuse type. Regarding C-MYC gene, a significant difference (P < 0.05) was observed between the two histological types. The C-MYC protein was expressed in all the studied cases. In the intestinal- type the C-MYC immunoreactivity was localized only in the nucleus and in the diffuse type in the nucleus and cytoplasm. CONCLUSION: Distinct patterns of alterations between intestinal and diffuse types of gastric tumors support the hypothesis that these types follow different genetic path- ways. | Danielle Queiroz Calcagno Mariana Ferreira Leal Aline Damaceno Seabra Andre Salim Khayat Elizabeth Suchi Chen Samia Demachki Paulo Pimentel Assumpcao Mario Henrique Girao Faria Silvia Helena Barem Rabenhorst Márcia Valéria Pitombeira Ferreira Marília de Arruda Cardoso Smith Rommel Rodríguez Burbano | 2006 | World Journal of Gastroenterology2006，12，38： | 9 |
| 3 | Rice Drying,Storage and Processing:Effects of Post-Harvest Operations on Grain Quality显示文摘Various post-harvest processes of rice are commonly employed,especially during the off-season,to ensure its consumption feasibility,which often affect the grain quality.Different forms of drying,storage and processing of rice are evaluated to identify their effects on grain quality.Microwave drying has emerged as an alternative to the widely-used intermittent-drying and fixed-bed-dryer methods of drying paddy rice.Control of drying-air temperatures(between 40℃ and 60℃)according to the rice variety can improve quality,especially for exotic varieties.Keeping stored grain in hygroscopic balance,with water content between 11%to 15%,at temperatures between 16℃ and 20℃ and with intergranular relative humidity near 60%,allows 12 months of storage in a controlled environment without significant deterioration.Other innovations,notably the application of artificial refrigeration to grain stored in bulk in vertical cylindrical silos and the use of impermeable packaging for storage,ensure the conservation of grain mass.The different stages and equipments used to obtain polished,brown and parboiled rice result in significant changes in the nutritional value of rice because of the removal of the outermost layers of the grains.Polishing reduces the nutritional value and physical homogeneity of rice.Brown rice retains more bioactive compounds and nutrients because it does not lose the outer layer of the grains in the polishing processes.Parboiled rice,although less nutritious than brown rice,has better grain integrity and milling yield and less loss of nutrients than white rice. | Amanda MÜLLER Marcela Trojahn NUNES Vanessa MALDANER Paulo Carteri CORADI Rosana Santos de MORAES Samuel MARTENS Andressa Fernandes LEAL Vladison Fogliato PEREIRA Cristielle König MARIN | 2022 | Rice science2022，29，1： | 3 |
| 4 | Reversible and athermal photo-vitrification of As50 ·Se50 thin films deposited onto silicon wafer and glass substrates 显示文摘 | PRIETO - ALCON R MARQUEZ E GONZALEZ- LEAL J M | 1999 | Appl Phys A1999，68，： | 2 |
| 5 | Fungal antioxidant pathways promote survival against neutrophils during infection显示文摘 | Leal Sixto M Vareechon Chairut Cowden Susan Cobb Brian A Latgé Jean-Paul Momany Michelle Pearlman Eric | 2012 | EN2012，，7： | 2 |
| 6 | Direct comparison of ISF-FDG PET and PET/CT in patients with colorectal carcinoma显示文摘 | Cohade C Osman M Leal J | 2003 | J Nucl Med2003，44，11： | 1 |
| 7 | Olfactory receptor neu rons detecting plant odours and male volatiles in Anomala cu prea beetles (Coleoptera: Searabaeidae) 显示文摘 | Lasson M C Leal W S Hansson B S | 2001 | Journal of Insect Physiology2001，47，： | 1 |
| 8 | Kairomone from dan-delion, Taraxacum officinale, attraetant for scarab beetle Anornala octiescostata 显示文摘 | Leal W S Ono M Hasegawa M | 1994 | Journal of Chemical Ecology1994，20，7： | 1 |
| 9 | Unusual periodicity of sex pheromone production in the large black chafer Holotrichia paraUela显示文摘 | Leal W S Sawada M Matsuyarna S | 1993 | Journal of Chemical Ecology1993，19，： | 1 |
| 10 | Detection of epithelial apoptosis in pelvic ileal pouches for ulcerative colitis and familial adenomatous polyposis显示文摘 | Leal RF Ayrizono Mde L Milanski M | 2010 | J Transl Med2010，8，11： | 1 |
| 11 | Atrophic changes in the trigeminal nerves of patients with trigeminal neuralgia due to neurovascular compression and their association with the severity of compression and clinical outcomes 显示文摘 | Leal PR Barbier C Hermier M | 2014 | J Neurosurg2014，120，： | 1 |
| 12 | Unusual periodicity of sex pheromone production in the large black chafer Ho lotrichia Darallela显示文摘 | Leal W S Sawada M Matsuyama S | 1993 | J Chem Ecol1993，19，： | 1 |
| 13 | Female sex pheromone of the longhorn beetle Migdolus fryanus Westwood: N- ( 2' S ) - methylbutanoyl 2-methylbutlyamine 显示文摘 | Leal W S Bento J M S Vilela E F | 1994 | Experientia1994，50，： | 1 |
| 14 | Interspecies prediction of human drug clearance based on scaling data from one or two animal species 显示文摘 | Tang H Hussain A Leal M Mayersohn M Fluhler E | 2007 | Drug Metab Dispos2007，36，10： | 1 |
| 15 | PM01183, a new DNA minor groove covalent binder with potent in vitro and in vivo anti-tumor activity显示文摘 | Leal JFM Martinez-Diez M Garcia-Hernandez V | 2010 | Br d Pharmacol2010，161，5： | 1 |
| 16 | Experimental trajectories of two drops in planar extensional flow 显示文摘 | Tretheway D C Muraoka M Leal L G | 1999 | Physics of Fluids1999，11，5： | 1 |
| 17 | Degradation of natural organic matter by TiO2 photocatalytic oxidation and its effect on fouling of low - pressure membranes显示文摘 | HUANG X LEAL M LI Q | 2008 | Water Res2008，42，： | 1 |
| 18 | The relationship between pcriodontitis and preteerm low birthweight 显示文摘 | Vettore M V Leal M Leao A T | 2008 | J Dent Res2008，87，1： | 1 |
| 19 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | Simone Cristina Méo Cláudia Lima Verde Leal Joaquim Mansano Garcia | 2004 | Animal Reproduction Science2004，81，： | 1 |
| 20 | Activation and early parthenogenesis of bovine oocytes treated with ethanol and strontium显示文摘 | MEO S C LEAL C L GARCIA J M | 2004 | Anim Reprod Sci2004，81，： | 1 |
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