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| 1 | Pharmacokinetics and toxicology of therapeutic proteins:Advances and challenges显示文摘Significant progress has been made in understanding pharmacokinetics (PK),pharmacodynamics (PD),as well as toxicity profiles of therapeutic proteins in animals and humans,which have been in commercial development for more than three decades.However,in the PK arena,many fundamental questions remain to be resolved.Investigative and bioanalytical tools need to be established to improve the translation of PK data from animals to humans,and from in vitro assays to in vivo readouts,which would ultimately lead to a higher success rate in drug development.In toxicology,it is known,in general,what studies are needed to safely develop therapeutic proteins,and what studies do not provide relevant information.One of the major complicating factors in nonclinical and clinical programs for therapeutic proteins is the impact of immunogenicity.In this review,we will highlight the emerging science and technology,as well as the challenges around the pharmacokinetic-and safety-related issues in drug development of mAbs and other therapeutic proteins. | Yulia Vugmeyster Frank-Peter Theil Leslie A Khawli Michael W Leach | 2012 | World Journal of Biological Chemistry2012，3，4： | 3 |
| 2 | Synergistic effect of a recombinant N-terminal fragment of bactericidal/permeability-increasing protein and cefamandole in treatment of rabbit Gram-negative sepsis显示文摘 | Lin Y Leach WJ Ammons W S | 1996 | Antimicrob Agents Chemother1996，40，1： | 1 |
| 3 | Anti-inflammatory activity of Chinese medicinal vine plants显示文摘 | Rachel W Li G David Lin Stephen P Myers David N Leach | 2002 | Journal of Ethnopharmacology2002，，1： | 1 |
| 4 | Anger and guilt about ingroup advantage explain the willingness for political aetion显示文摘 | Leach C W Iyer A Pedersen A | 2006 | Person- ality and Social Psychology Bulletin2006，32，9： | 1 |
| 5 | The relationship between chemiosmotic parameters and sensitivity to anions and organic acids in the acidophile Thiobacillus ferrooxidans显示文摘 | ALEXANDER B LEACH S 1NGLEDE W J | 1987 | Microbiology1987，133，5： | 1 |
| 6 | Upward So- cial Comparison and Self-concept:Inspiration and Inferiori- ty among Art Student in An Advanced Programme 显示文摘 | Burleson K C W Leach C W Harrington D M | 2005 | The British Journal of Social Psychology2005，44，1： | 1 |
| 7 | Structure of the starch granule Ⅱ action of various amylases on granular 显示文摘 | Leach H W Schoch T J | 1961 | Starch Cereal Chem1961，，38： | 1 |
| 8 | Microscopic study of the initial stages of eggshell calcification 显示文摘 | STEMBERGER B H MUELLER W J LEACH R M | 1977 | Poultry Sci1977，56，： | 1 |
| 9 | Cadmium and the food chain:The effect of dietary cadmium on tissue composition in chicks and laying hens显示文摘 | LEACH R WANG K W BAKER D E | 1979 | Nutrition1979，109，： | 1 |
| 10 | Respiratory detoxification of nitric oxide by the cytochrome c reductase of Escherichia coli 显示文摘 | Pook S Leach R Moir W | 2008 | Journal of Biological Chemistry2008，277，23： | 1 |
| 11 | Probe-compensated near-field measurements on a cylinder 显示文摘 | Leach W M Paris D T | 1973 | IEEE Transactions on Antennas Propagation1973，21，4： | 1 |
| 12 | Experimental evidence for a dual pathway model analysis of coping with the climate cri- sis显示文摘 | Van Zomeren M Spears R Leach C W | 2010 | Journal of Environmental Psychology2010，30，4： | 1 |
| 13 | Genetic,growth and reproductive effects of microwave radia tion显示文摘 | Leach W M | 1980 | BuU N Y Academic Medicine1980，55，2： | 1 |
| 14 | An essential role for interleukin 10 in the function of regulatory T cells that inhibit intestinal inflammation显示文摘 | Mauze S Leach M W | 1999 | J Exp Med1999，190，7： | 1 |
| 15 | Continuous passive motion following total knee replacement:a respective randomized trial with follow-up to 1 year显示文摘 | Leach W Reid J Murphy F | 2006 | Knee Surg Sports Traumatol Arthrosc2006，14，： | 1 |
| 16 | Irradiation of the ear显示文摘 | Leach W | 1965 | J Larygnol1965，79，： | 1 |
| 17 | Gulf Coast Tertiary-1:New exploration enhancements in south Louisiana Tertiary sediments显示文摘 | Leach W G | 1993 | Oil and Gas Journal1993，91，9： | 1 |
| 18 | Theory Testing Using Case Studies in Business-to-Business Research显示文摘 | Johnston W J Leach M P Liu A H | 1999 | Industrial Marketing Management1999，28，3： | 1 |
| 19 | Gulf Coast Tertiary-2 : Fluid migration, hydrocarbon concentration in south Louisiana Tertiary sands显示文摘 | Leach W G | 1993 | Oil and Gas Journal1993，91，11： | 1 |
| 20 | Guilt, an- ger, and pride about in-group environmental behav- iour: Different emotions predict distinct intentions 显示文摘 | HARTH N S LEACH C W KESSLER T | 2013 | Journal of Environmental Psychology2013，34，： | 1 |
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