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| 1 | A Statistical Study on Seismo-Ionospheric Anomalies of the Total Electron Content for the Period of 56 M≥6.0 Earthquakes Occurring in China During 1998—2012显示文摘This paper reports statistical results of Seismo-Ionospheric Anomalies(SIAs) of the Total Electron Content(TEC) in the Global Ionosphere Map(GIM) associated with 56 M≥6.0 earthquakes in China during 1998—2012.To detect SIA,a quartile-based(i.e.median-based) process is performed.TEC anomalies for the period of earthquakes without being led by magnetic storms about 10 days are further isolated and examined to confirm the SIP existence.Results show that SIA is the TEC significantly decrease in the afternoon period 2—9 days before the earthquakes in China,which is in a good agreement with the SIA appearing before the 12 May 2008 M 8.0 Wenchuan earthquake. | Liu J Y Chen C H Tsai H F Le H | 2013 | 空间科学学报2013，33，3： | 7 |
| 2 | FOLFIRINOX and translational studies: Towards personalized therapy in pancreatic cancer显示文摘Pancreatic cancer is an extremely aggressive disease; although progress has been made in the last few years, the prognosis of these patients remains dismal. FOLFIRINOX is now considered a standard treatment in first-line setting, since it demonstrated an improved overall and progression-free survival vs gemcitabine alone. However, the enthusiasm over the benefit of this three-drug regimen is tempered by the associated increased toxicity profile, and many efforts have been made to improve the feasibility of this schedule. After a more recent phase Ⅲ trial showing an improved outcome over gemcitabine, the combination of gemcitabine/nab-paclitaxel emerged as another standard first-line treatment. However, this treatment is also associated with more side effects. In addition, despite initial promising data on the predictive role of SPARClevels, recent studies showed that these levels are not associated with nab-paclitaxel efficacy. The choice to use this treatment over FOLFIRINOX is therefore a topic of debate, also because no validated biomarkers to guide FOLFIRINOX treatment are available. In the era of actionable mutations and target agents it would be desirable to identify molecular factors or biomarkers to predict response to therapy in order to maximize the efficacy of treatment and avoid useless toxic effects for non-responding patients. However, until today the milestone of treatment for pancreatic cancer remains chemotherapy combinations, without predictive or monitoring tools existing to optimize therapy. This review analyzes the state-of-the-art treatments, promises and limitations of targeted therapies, ongoing trials and future perspectives, including potential role of microR NAs as predictive biomarkers. | Chiara Caparello Laura L Meijer Ingrid Garajova Alfredo Falcone Tessa Y Le Large Niccola Funel Geert Kazemier Godefridus J Peters Enrico Vasile Elisa Giovannetti | 2016 | World Journal of Gastroenterology2016，22，31： | 4 |
| 3 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 4 | Second-look surgery plus hyperthermic intraperitoneal chemotherapy for patients with colorectal cancer at high risk of peritoneal carcinomatosis:Does it really save lives?显示文摘The treatment of peritoneal carcinomatosis (PC) of colorectal origin with cytoreductive surgery(CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) has a 5-year recurrence-free or cure rate of at least 16%, so it is no longer labeled as a fatal disease, and offers prolonged survival for patients with a low peritoneal carcinomatosis index. Metachronous PC of colorectal origin is so predictable that there is a model which has been used to successfully determine the individual risk of each patient. Patients at risk are clearly identified; those with the highest risk have small peritoneal nodules present in the first surgery (70% probability of developing PC), ovarian metastases(60%), perforated tumor onset or intraoperative tumor rupture(50%). Current clinical, biological and imaging techniques still lack sufficient sensitivity to diagnose PC in its initial stages, when CRS plus HIPEC has a greater impact and a higher cure rate. Second-look surgery with HIPEC or prophylactic HIPEC at the time of the first intervention have been proposed as means of preventing and/or anticipating clinical or radiological relapse in at-risk patients. Both techniques have shown a significant decrease in peritoneal relapses and should be considered essential weapons in the management of colorectal cancer. | Delia Cortes-Guiral Dominique Elias Pedro Antonio Cascales-Campos Alfredo Badía Yébenes Ismael Guijo Castellano Ana Isabel León Carbonero JoséIgnacio Martín Valadés Jesus Garcia-Foncillas Damian Garcia-Olmo | 2017 | World Journal of Gastroenterology2017，23，3： | 3 |
| 5 | 艾滋病病毒相关性原发性脑淋巴瘤的放疗疗效显示文摘目的:探讨艾滋病病毒相关性原发性脑淋巴瘤放射治疗的疗效。方法:从 1995年1月至 1999年 12月法国巴黎第十二大学Henri Mondor医院放疗科共收治艾滋病病毒相关性原发性脑淋巴瘤病人8例,均为男性,中位年龄为32岁(21~57岁)。8例病人均接受全脑照射30 Gy,后有4例缩野照射原发肿瘤 15~20 Gy,中位照射剂量为 37 .5 Gy。所有病人均未接受化疗。结果:放疗结束时,肿瘤缩小4例,肿瘤无变化 3例,肿瘤增大 1例;病人对急性放射反应耐受性尚好。病人中位生存期为7.1个月(3~19个月)。结论:艾滋病病毒相关性原发性脑淋巴瘤病人的预后差,而放射治疗可在一定程度上延长病人的生存期。 | 曹卡加 Luo DF Kirova Y Le Bourguois JP | 2001 | 癌症2001，20，6： | 3 |
| 6 | 无针喷注器注射博来霉素治疗瘢痕疙瘩和肥厚性瘢痕的一项初步研究显示文摘Background: Numerous treatment modalities have been used to treat keloids and hypertrophic scars, but the optimal treatment has not been established. Objectiv e: The aim of this study was to determine the efficacy and safety of intralesion al jet injection of bleomycin as therapy for keloids and hypertrophic scars that are unresponsive to intralesional steroid injection. Methods: The study include d 14 patients with 15 keloids or hypertrophic scars that had not responded to a minimum of three intralesional injections of triamcinolone acetonide. Multiple j et injections of 0.1 ml of bleomycin (1.5 IU/ml) were administered to each lesio n, with injection sites spaced 0.5 mm apart. Injections were repeated each month . Scar height was measured, and scar pliability and erythema were scored at base line and then monthly during the treatment and followup periods. Patients’self -assessments of subjective symptoms (pruritus and pain)were also scored. Clinic al improvementwas defined primarily on the basis of scar height reduction (perce ntage reduction from baseline), and was classified using the following scale: co mplete flattening (100%), highly significant flattening (> 90%), significant f lattening (75-90%), moderate flattening (50-75%), and minimal flattening (< 50%). Preand post-treatment mean values for scar height, scar pliability, eryt hema, pruritus and pain were statistically compared. Results: The number of sess ions required to successfully treat the lesions ranged from two to six. Eleven l esions (73.3%) showed complete flattening, one (6.7%) showed highly significan t flattening, two (13.3%) showed significant flattening, and one scar (6.7%) s howed moderate flattening. The mean scar height was significantly lower, and the mean scores for scar pliability and erythema were significantly better at the e nd of treatment (P < 0.001, P < 0.001 and P < 0.001, respectively). The mean sco res for pruritus and pain also improved significantly (P < 0.001 and P=0.01, res pectively). The observed side-effects were hyperpigmentation (four lesions) and skin atrophy (three lesions). No recurrences were noted during follow up (mean duration of 19 months). Conclusions: Intralesional jet injection of bleo mycin is an effective and safe method of treating keloids and hypertrophic scars that are unresponsive to intralesional steroid therapy. | Saray Y GüleT 冯义国 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，1： | 2 |
| 7 | Estrogen provides neuroprotection against activated microglia-induced dopaminergic neuronal injury through both estrogen receptor-alpha and estrogen receptor-beta in microglia显示文摘 | Liu X Fan XL Zhao Y Luo GR Li XP Li R Le WD | 2006 | 中国生物学文摘2006，20，10： | 2 |
| 8 | Acute-on-chronic liver failure: Controversies and consensus显示文摘Acute-on-chronic liver failure(ACLF)is a poorly defined syndrome characterised by rapid clinical deterioration in patients with chronic liver disease.Consequences include high short-term morbidity,mortality,and healthcare resource utilisation.ACLF encompasses a dysregulated,systemic inflammatory response,which can precipitate extra hepatic organ failures.Common precipitants include infection,alcoholic hepatitis,and reactivation of viral hepatitis although frequently no cause is identified.Heterogenous definitions,diagnostic criteria,and treatment guidelines,have been proposed by international hepatology societies.This can result in delayed or missed diagnoses of ACLF,significant variability in clinical management,and under-estimation of disease burden.Liver transplantation may be considered but the mainstay of treatment is organ support,often in the intensive care unit.This review will provide clarity around where are the controversies and consensus in ACLF including:Epidemiology and resource utilisation,key clinical and diagnostic features,strategies for management,and research gaps. | Natalie L Y Ngu Eliza Flanagan Sally Bell Suong T Le | 2023 | World Journal of Gastroenterology2023，29，2： | 2 |
| 9 | Comparative bioavai Labi Lity study of cefixime ainistered as tab Letes or queous solution 显示文摘 | Montay G MasaLa F Le Roux Y | 1991 | Drugs1991，42，4： | 2 |
| 10 | Comparison of the ABI7700 system (Taq Man) and competitive PCR for quantification of IS6110 DNA in sputum during treatment of tuberculosis 显示文摘 | Desjardin LE Chen Y Perkins MD | 1998 | J Clin Microbil1998，36，7： | 1 |
| 11 | Recent advances in our understanding of insulin action and insulin resistance显示文摘 | Le Roith D Zick Y | 2001 | Diabetes Care2001，24，3： | 1 |
| 12 | The rol of functional MR imaging in patients with ischemia in the visual cortex显示文摘 | Chung TS Soo Y | 2001 | AJNR Am J Neuroradiol2001，22，： | 1 |
| 13 | EENA promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish显示文摘 | Le H Y Zhang Y Liu H | 2008 | J Biol Chem2008，25，17： | 1 |
| 14 | The temporal relation be- tween depression symptoms, cardiovascular disease events and mortality in ESRD: Contribution of reverse causality显示文摘 | Bouleware LE Liu Y Fink NE | 2006 | Clin J Am Soc Nephrol2006，1，： | 1 |
| 15 | Measuring the VC-dimension of a Learning Machine显示文摘 | Vapnik V Levin E Le Cun Y | 1994 | Neural Computation1994，6，： | 1 |
| 16 | Reexpression of the tumor suppressor gene ARHI induces apoptosis in ovarian and breast cancer cells through a caspase-independent calpain-dependent pathway 显示文摘 | Bao J J Le X F Wang R Y | 2002 | Cancer Res2002，62，24： | 1 |
| 17 | Molecular phylogeny of the Ceratosolen species pollinating Ficus of the subgenus Sycomorus sensu stricto: biogeographical history and origins of the species-specificity breakdown case显示文摘 | Kerdelhue C Le Clainche I Rasplus J Y | 1999 | Mol Phylogenet Evol1999，11，： | 1 |
| 18 | Caspase activation and neuroprotection in caspase-3 deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation 显示文摘 | Le D Wu Y Huang Z | 2002 | Proc Natl Acad Sci2002，99，15： | 1 |
| 19 | Propagating Extrusion Tectonies in Asia: New Insights from Simple Experiments with Plastieine显示文摘 | Tapponnier P Peltzer G le Dain A Y | 1982 | Geology1982，10，： | 1 |
| 20 | Proteolysis in samples of quarter milk with varying somatic cell counts显示文摘 | LE ROUX Y COLIN O LAURENT F | 1995 | Dairy Sci1995，78，： | 1 |
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