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| 1 | Microarray,SAGE and their applications to cardiovascular diseases显示文摘The wealth of DNA data generated by the human genome project coupling with recently invented high-throughput gene expression profiling techniques has dramatically sped up the process for biomedical researchers on elucidating the role of genes in human diseases. One powerful method to reveal insight into gene functions is the systematic analysis of gene expression. Two popular high-throughput gene expression technologies, microarray and Serial Analysis of Gene Expression (SAGE) are capable of producing large amounts of gene expression data with the potential of providing novel insights into fundamental disease processes, especially complex syndromes such as cardiovascular disease, whose etiologies are due to multiple genetic factors and their interplay with the environment. Microarray and SAGE have already been used to examine gene expression patterns of cell-culture, animal and human tissues models of cardiovascular diseases. In this review, we will first give a brief introduction of microarray and SAGE technologies and point out their limitations. We will then discuss the major discoveries and the new biological insightsthat have emerged from their applications to cardiovascular diseases. Finally we will touch upon potential challenges and future developments in this area. | SHUI QING YE, TERA LAVOIE, DAVID C USHER, LI Q. ZHANG1 Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, School of Medicine, Baltimore, MD 21224, USA2Department of Biological Science, University of Delaware, Newark, DE 19716, USA | 2002 | Cell Research2002，12，2： | 5 |
| 2 | In vivo activity of mutacin B-Ny266显示文摘 | MOTA-MEIRA M MORENCY H LAVOIE M C | 2005 | J Antimicrob Chemother2005，56，5： | 1 |
| 3 | On the kinematic design of spherical 3-dof parallel manipulators显示文摘 | Gosselin C M Lavoie E | 1993 | The International Journal of Robotics Research1993，12，4： | 1 |
| 4 | Effects of systemic corticoRteroids on cutaneous histamine secretion and histamine-R releasing factor in patients with chronic idiopathic urticaria显示文摘 | Paradis L Lavoie A Brunet C | 1996 | Clin Exp Allergy1996，26，： | 1 |
| 5 | Assessment of fecal bacteria with bile acid 7 alpha-dehydroxylating activity for the presence of bai-like genes显示文摘 | DOEMER K C TAKAMINE F LAVOIE C P | 1997 | Appl Environ Microbiol1997，63，3： | 1 |
| 6 | eNOS gene delivery pre-vents hypertension and reduces renal failure and injury in rats withreduced renal mass显示文摘 | Savard S Lavoie P Villeneuve C | 2012 | Nephrol Dial Transplant2012，27，6： | 1 |
| 7 | Glucose or intermittent high-intensity exercise in glargine/glulisine users with T1DM显示文摘 | Dubé MC Lavoie C Weisnagel SJ | 2013 | Med Sci Sports Exerc2013，45，1： | 1 |
| 8 | eNOS gene delivery prevents hypertension and reduces renal failure and injury in rats with reduced renal mass 显示文摘 | Savard S Lavoie P Villeneuve C | 2012 | Nephrol Dial Transplant2012，27，6： | 1 |
| 9 | An atherogenic diet decreases liver FXR gene expression and causes severe hepatic steatosis and hepatic cholesterol accumulation:effect of endurance training显示文摘 | C(o)té I Sock ETN Lévy (E) Lavoie J-M | | 0，，： | 1 |
| 10 | Hydrothermal dolomitization in the Lower Silurian Sayabec Formation in northern Gaspé-Matapia (Québec):Constraint on timing of porosity and regional significance for hydrocarbon reservoirs显示文摘 | Lavoie D Morin C | 2004 | Bulletin of Canadian Petroleum Geology2004，52，3： | 1 |
| 11 | Minireview:Overview of the renninangiotensin system an endocrine and paracrine system显示文摘 | Lavoie J L Sigmund C D | | 0，，06： | 1 |
| 12 | New Approa- ches of organizing care and work giving way to participation mo- bilization and Innovation显示文摘 | Viens C Lavoie - Tremblay M Leclerc MM | 2005 | The Health Care Manger2005，24，2： | 1 |
| 13 | Minireview: overview of the renin angiotensin system an endocrine and paracrine sys- tem显示文摘 | LAVOIE J L SIGMUND C D | 2003 | Endocrinology2003，144，6： | 1 |
| 14 | Isolation and identification of anti-algal substances produced by Pseudomonas aeruginosa 显示文摘 | DAKHAMA A NOUE J D LAVOIE M C | 1993 | Journal of Applied Phycology1993，5，3： | 1 |
| 15 | Thermal expansion of the isostructural PtSi and NiSi:Negative expansion coefficient in NiSi and stress effects in thin films显示文摘 | Detavernier C Lavoie C d'Heurle F M | 2003 | J Appl Phys2003，93，： | 1 |
| 16 | Dissociation of dilute immiscible copper alloy thin films 显示文摘 | BARMAK K LUCADAMO G A CABRAL C Jr LAVOIE C HARPER J M E | 2000 | Journal of Applied Physics2000，87，： | 1 |
| 17 | CFD Analysis of Conjugate Heat Transfer in dry -type Transformer 显示文摘 | Ortiz C Skorek A W Lavoie Parallel M | 2009 | IEEE Transaetions on Industry Applications2009，45，4： | 1 |
| 18 | 显示文摘 | Kim H Lavoie C Copel M | 2004 | J Appl Phys2004，95，： | 1 |
| 19 | Isolation and identification of antialgal substances produced by Pseudomonas aeruginosa显示文摘 | Dakhama A Noue J D Lavoie M C | 1993 | Appl Phyol1993，，5： | 1 |
| 20 | Algal growth enhancement by bacteria:Is consumption of photosynthetic oxygen involved显示文摘 | MOUGET J L DAKHAMA A LAVOIE M C | 1995 | FEMS Microbiol Ecol1995，18，： | 1 |
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