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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | High-energy hybrid femtosecond laser system demonstrating 2×10 PW capability显示文摘We report on a two-arm hybrid high-power laser system(HPLS)able to deliver 2×10 PW femtosecond pulses,developed at the Bucharest-Magurele Extreme Light Infrastructure Nuclear Physics(ELI-NP)Facility.A hybrid frontend(FE)based on a Ti:sapphire chirped pulse amplifier and a picosecond optical parametric chirped pulse amplifier based on beta barium borate(BBO)crystals,with a cross-polarized wave(XPW)filter in between,has been developed.It delivers 10 mJ laser pulses,at 10 Hz repetition rate,with more than 70 nm spectral bandwidth and high-intensity contrast,in the range of 1013:1.The high-energy Ti:sapphire amplifier stages of both arms were seeded from this common FE.The final high-energy amplifier,equipped with a 200 mm diameter Ti:sapphire crystal,has been pumped by six 100 J nanosecond frequency doubled Nd:glass lasers,at 1 pulse/min repetition rate.More than 300 J output pulse energy has been obtained by pumping with only 80%of the whole 600 J available pump energy.The compressor has a transmission efficiency of 74%and an output pulse duration of 22.7 fs was measured,thus demonstrating that the dual-arm HPLS has the capacity to generate 10 PW peak power femtosecond pulses.The reported results represent the cornerstone of the ELI-NP 2×10 PW femtosecond laser facility,devoted to fundamental and applied nuclear physics research. | François Lureau Guillaume Matras Olivier Chalus Christophe Derycke Thomas Morbieu Christophe Radier Olivier Casagrande Sébastien Laux Sandrine Ricaud Gilles Rey Alain Pellegrina Caroline Richard Laurent Boudjemaa Christophe Simon-Boisson Andrei Baleanu Romeo Banici Andrei Gradinariu Constantin Caldararu Bertrand De Boisdeffre Petru Ghenuche Andrei Naziru Georgios Kolliopoulos Liviu Neagu Razvan Dabu Ioan Dancus Daniel Ursescu | 2020 | High Power Laser Science and Engineering2020，8，4： | 4 |
| 3 | Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase(PHGPx)显示文摘 | Moreno S G Laux G Brielmeier M | 2003 | Biol Chem2003，384，： | 1 |
| 4 | A point mutant of GAP-43 induces enhanced short-term and long-term hippocampal plasticity显示文摘 | Hulo S Alberi S Laux T | 2002 | Eur J Neurosci2002，15，： | 1 |
| 5 | Relevance of parents as source for contamination of neonates with multiresistant gram-negative pathogens(MRGN)显示文摘 | Laux R Wirtz S Huggett S | 2013 | Z Geburtshilfe Neonatol2013，217，2： | 1 |
| 6 | Room-temperature deposition of indium tin oxide thin films with plasma ion-assisted evaporation显示文摘 | Laux S Kaiser N Zoller A | 1998 | Thin Solid Films1998，335，12： | 1 |
| 7 | Epidermal growth factor receptor dimerization status determines skin toxicity to HER-kinase targeted therapies显示文摘 | Laux I Jain A Singh S | 2006 | Br J Cancer2006，94，1： | 1 |
| 8 | Embryonic development in Arabidopsis thaliana:from the zygote division to the shoot meristem显示文摘 | BOSCA S KNAUER S LAUX T | 2011 | Frontiers in Plant Science2011，2，： | 1 |
| 9 | Epidermal growth factor re- ceptor dimerization status determines skin toxicity to HER- kinase targeted therapies显示文摘 | Laux I Jain A Singh S | 2006 | Br J Cancer2006，94，1： | 1 |
| 10 | Techniques for Small-Signal Analysis of Semiconductor Devices显示文摘 | Laux S E | 1986 | IEEE Transactions on Electron Devices1986，32，4： | 1 |
| 11 | Plasma concentrations of aminoterminal proatrial natriuretic peptide and aminoterminal probrain natriuretic peptide in healthy neonates:marked and rapid increase after birth显示文摘 | MIR T S LAUX R HELLWEGE H | 2003 | Pediatrics2003，112，： | 1 |
| 12 | Room-temperature deposition of indium tin oxide thin films with plasma ion-assisted evaporation 显示文摘 | Laux S Kaiser N Zoler A | 1998 | Thin Solid Films1998，335，： | 1 |
| 13 | Electron states in a GaAs quantum dot in a magnetic field显示文摘 | KUMAR A LAUX S E STERN F | 1990 | PhysRev B1990，42，8： | 1 |
| 14 | Value and actuality of the prescription information for therapeutic drug monitoring of psychopharmaceuticals: a comparison with the medico-scientific evidence 显示文摘 | ULRICH S HIEMKE C LAUX G | 2007 | Pharmacopsychiatry2007，40，3： | 1 |
| 15 | Electron states in a GaAs quantum dot in a magnetic field显示文摘 | KUMAR A LAUX S E STERN F | 1990 | Phys Rev1990，42，： | 1 |
| 16 | A point mutant of GAP-43 induces enhanced short-term and long-term hippocampal plasticity 显示文摘 | Hulo S Alberi S Laux T | 2002 | Eur J Neurosci2002，15，12： | 1 |
| 17 | Band structure, deformation po- tentials, and carrier mobility in strained Si, Ge, and SiGe alloys 显示文摘 | Fischetti M V Laux S E | 1996 | J Appl Phys1996，80，4： | 1 |
| 18 | Room temperature deposition of indium tin oxide thin films with plasma ion-assisted evaporation 显示文摘 | Laux S Kaiser N Zoller A | 1998 | Thin Solid Films1998，335，： | 1 |
| 19 | Case management of arthritis patients in primary care: a cluster-randomized controlled trial显示文摘 | Rosemann T Joos S Laux G | 2007 | Arthritis Rheum2007，57，： | 1 |
| 20 | On the existence of an optimal tick size显示文摘 | Brown S H Laux P Schachter B | 1991 | Review of Futures Markets1991，，10： | 1 |
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