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| 1 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 2 | Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice显示文摘AIM:To study the possible interactions of metoclopramide,domperidone and erythromycin in streptozotocin-induced diabetic mice treated with insulin by various parameters.METHODS:Effects of the individual as well as combined drugs were studied in diabetic mice via estimation of the blood glucose and serum insulin levels,small intestinal transit(SIT),gastric emptying(GE),xylose absorption and glucose tolerance tests.Groups were given insulin 2 IU/kg s.c.,metoclopramide 20 mg/kg p.o.,domperidone 20 mg/kg p.o.and erythromycin 6 mg/kg p.o.individually and in combination.There were also normal and diabetic control groups.The first set of experiments was carried out to investigate the subchronic effect on blood glucose and serum insulin levels in diabetic mice of one week of daily dose administration of the tested drugs individually as well as the combination of insulin with each prokinetic drug.The other five sets of experiments were carried out to investigate the acute effect of a single dose of each drug individually and in combination on blood glucose and serum insulin levels,SIT,GE,oral xylose absorption and glucose tolerance tests.RESULTS:The study included the prokinetic drugs metoclopramide(20 mg/kg),domperidone(20 mg/kg) and erythromycin(6 mg/kg),as well as insulin(2 IU/kg),which was individually effective in decreasing SIT,enhancing GE and increasing xylose absorption significantly in diabetic mice.Erythromycin tended to decrease blood glucose level and increase serum insulin level after 1 wk of daily administration in diabetic mice.Erythromycin potentiated the effect of insulin on blood glucose level and serum insulin level whereas other prokinetic agents failed to do so after repeated dose administration in diabetic mice.Metoclopramide or erythromycin in combination with insulin significantly decreased SIT,in diabetic mice,to lower levels than with insulin alone.Administration of prokinetic drugs along with insulin antagonized the action of insulin on xylose absorption.These combinations also increased the rate of glucose absorption from the gut.CONCLUSION:The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients,matched to the action of exogenous insulin.The use of prokinetics,such as erythromycin,may be interesting in the clinic in decreasing the need for insulin in diabetic patients.The dose of insulin may be safely decreased with erythromycin in chronic treatments. | Mohamed A Fouad Shalaby Hekma A Abd El Latif Mostafa E El Sayed | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 3 |
| 3 | Different techniques recently used for the treatment of textile dyeing effluents= a review 显示文摘 | Latif A Noor S Sharif Q M Najeebullah M | 2010 | Journal of the Chemical Societyof Pakistan2010，32，： | 1 |
| 4 | On Hadamard-type inequalities for h - convex function on the co-ordinates显示文摘 | Latif M A Alomari M | | 0，，33： | 1 |
| 5 | Design and management of high-performance, reliable and thermal-aware 3D networks on chip 显示文摘 | RAHMANI A M VADDINA K R LATIF K | 2012 | lET Circuits Devices Syst2012，6，30： | 1 |
| 6 | Reducing medication errors incritical care: a multimodal approach显示文摘 | Kruer RM Jarrell AS Latif A | 2014 | Clin Pharmacol2014，6，： | 1 |
| 7 | Uric acid (evels and all-cause and cardiovascular mortality in the hemodialysis population显示文摘 | Latif W Karaboyas A Tong L | 2011 | Clin J Am Soc Nephrol2011，6，0： | 1 |
| 8 | Effects of environmental alkalinity on calcium-stimulated dephosphorylating enzyme activity in the gills of postmoult and intermoult giant freshwater prawns Macrobrachium rosenbergii(de Man)显示文摘 | Latif M A Brown J H Wickins J F | | 0，，： | 1 |
| 9 | Role of the Ras-association domain family 1 tumor suppressor gene in human cancer显示文摘 | Agathanggelou A Cooper WN Latif F | 2005 | Cancer Res2005，65，9： | 1 |
| 10 | On some refinements of Fej6r type inequalities via superquadratic functions 显示文摘 | Latif M A | 2011 | J Indones Math Soc2011，17，2： | 1 |
| 11 | Influence of some dietary organic mineral supplementations on broiler performance 显示文摘 | ABDALLAH A G EI-HUSSEINY O M ABDEL- LATIF K O | 2009 | Interna- tional Journal of Poultry Science2009，8，3： | 1 |
| 12 | Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to tamilial paraganglioma显示文摘 | Astuti D Latif F Dallol A | 2001 | Am J Hum Genet2001，69，1： | 1 |
| 13 | Targeting survival pathways in chronic myeloid leukaemia stem cells显示文摘 | Sinclair A Latif AL Holyoake TL | 2013 | Br J Pharmacol2013，169，8： | 1 |
| 14 | Gene mutations in the succinate dehydrogenase subunit SDHB cause susceptibility to familial pheochromocytoma and to familial paraganglioma 显示文摘 | Astuti D Latif F Dallol A | 2001 | Am J Hum Genet2001，69，1： | 1 |
| 15 | Impaired tamoxifen metabolism reduces survival in familial breast cancer patients显示文摘 | Newman WG Hadfield KD Latif A | 2008 | Clin Cancer Res2008，1408，： | 1 |
| 16 | Physiological integrity d hmmn sperm in the presence d ureaplasma urealyticum显示文摘 | SHALHOUB D ABDEL- LATIF A FREDERICKS C M | 1986 | Arch Androl1986，16，1： | 1 |
| 17 | Screening of Aspergillus niger strains for pectinases production potential 显示文摘 | HANNAN A BAJWA R LATIF Z | 2008 | 1 Bioteclmol2008，136，： | 1 |
| 18 | The thyroid-stimulating hormone receptor:impact of thyroid-stimulating hormone and thyroid-stimulating hormone receptor antibodies on multimerization,cleavage,and signaling显示文摘 | LATIF R MORSHED S A ZAIDI M | 2009 | Endocrinol Metab Clin North Am2009，38，2： | 1 |
| 19 | Role of the Ras-association domain family 1 tumor suppressor gene in human cancers显示文摘 | AGATHANGGELOU A COOPER W N LATIF F | 2005 | Cancer Res2005，65，7： | 1 |
| 20 | Northern Hemispheric interdecadal variability:A coupled air sea mode显示文摘 | TIMMERMANN A LATIF M VOSS R | 1998 | Journal of Climate1998，11，8： | 1 |
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