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| 1 | 微生物碳酸盐岩的成因、分类以及问题与展望——来自华北地台寒武系微生物碳酸盐岩研究的启示显示文摘微生物碳酸盐岩以其漫长的地史分布、多样的产出环境、复杂的沉积构成和与微生物活动密切相关的特性而成为沉积学研究的焦点,同时也是沉积学研究的难点,被誉为'最难研究的沉积岩之一'。其研究的中心主要是钙化微生物席和微生物膜及其地质记录,即石化/成岩作用的产物。从成因着手,系统总结和梳理了2个类型的微生物群落,较薄的生物膜和较厚的微生物席,经过生物/有机矿化作用和石化/成岩作用形成微生物碳酸盐岩的过程。提出除微生物群落自身的复杂性和沉积过程的复杂性之外,多重状生物膜是导致微生物碳酸盐岩多样性的另外一个重要原因。以中国华北地台寒武系微生物碳酸盐岩的研究为基础,梳理了不同类型的微生物碳酸盐岩的沉积特征和分类依据。认为微生物碳酸盐岩应该置于Embry和Kloven描述的黏结岩类下,根据宏观组构可进一步分为叠层石、凝块石、核形石、层纹石和均一石5类,树形石不易独立成类而应归于凝块石。微生物碳酸盐岩为整个地质历史时期与微生物活动相关的生物/有机矿化作用过程研究提供了有用信息,不但是了解地球表层环境演变的一个重要窗口,而且还形成和储集了较大规模的油气,具有重要的科学意义和经济价值。 | 王龙 Khalid Latif Muhammad Riaz 刘晓晔 | 2018 | 地球科学进展2018，33，10： | 18 |
| 2 | Visible light communication: applications, architecture, standardization and research challenges显示文摘 | Latif Ullah Khan | 2017 | Digital Communications and Networks2017，3，2： | 18 |
| 3 | 寒武系张夏组鲕粒滩中微生物碳酸盐岩主导的生物丘:以河北秦皇岛驻操营剖面为例显示文摘华北地台的寒武系苗岭统,大致包括毛庄组、徐庄组、张夏组和崮山组,这些组分别组成相应的三级沉积层序,在它们的顶部集中发育着鲕粒滩相灰岩而构成强迫型海退沉积,成为时间特化的相,代表着鲕粒主导的特别的寒武纪碳酸盐岩台地类型,表现在浅海陆架中大面积分布鲕粒滩,而且在这样的鲕粒滩中生长和发育着微生物碳酸盐岩主导的生物丘;河北省秦皇岛市驻操营剖面的张夏组上部鲕粒滩相灰岩中的生物丘正是上述现象最为典型的代表。虽然类似的现象曾经被描述为'藻坪'沉积,或者笼统地归为'微生物礁',但是,河北省秦皇岛市驻操营剖面的张夏组上部鲕粒滩相灰岩中的生物丘,以下现象不但将其特征化而且代表着壮观的沉积学现象:(1)在强迫型海退体系域的下部与鲕粒滩相灰岩交互产出的主要是柱状叠层石生物丘;(2)在张夏组顶部则以集中产出的均一石和树形石生物丘为特征;(3)下部的柱状叠层石生物丘中主要包括石松藻(Lithocodium)-孢网菌(Bacinella)状组构的钙化蓝细菌;(4)在上部集中产出的均一石与树形石生物丘,则发育着丝状钙化蓝细菌、基座菌(Hedstroemia)和附枝菌(Epiphyton)之类的多样化的钙化蓝细菌。由于石松藻(Lithocodium)-孢网菌(Bacinella)状组构的钙化蓝细菌是一种灭绝了的浅海生命形式,而且是不知道分类位置归属的生命形式,尤其是石松藻(Lithocodium)状组构近年来在寒武纪微生物碳酸盐岩研究中多被解释为'硅质海绵骨针的网状物'或'非骨针角质海绵骨骼纤维',再考虑到均一石自从命名以来很少描述在古老的地层记录之中,因此,驻操营剖面张夏组上部多样化微生物碳酸盐岩所主导的生物丘,以及生物丘中特别而且多样的钙化蓝细菌化石构成,为了解蓝细菌主导的光合作用微生物席复杂的钙化作用形成微生物碳酸盐岩提供了较为典型的实例。 | 梅冥相 Khalid Latif 孟庆芬 胡媛 | 2019 | 地质学报2019，93，1： | 17 |
| 4 | 鲕粒滩中光合作用生物膜构建的高能核形石:以辽西葫芦岛三道沟剖面寒武系张夏组为例显示文摘核形石是一种具有双重属性而较为特别的微生物碳酸盐岩:①作为一种包覆颗粒类型,核形石以不平滑的圈层和较大的大小被解释为微生物成因区别于成因存在着较大争议的鲕粒;②作为一种形成在围绕着核心的序列式纹层化作用过程中的球形或椭球型的生物沉积构造,核形石还常常被解释为微生物碳酸盐岩的一种类型而被归为球状叠层石。在辽西葫芦岛三道沟剖面寒武系苗岭统张夏组顶部的块状鲕粒滩相灰岩之中,密集发育着厘米级别大小的高能泥晶核形石。另外,以下重要特征将张夏组鲕粒灰岩中的核形石特征化,包括:①厘米级别的大小;②椭圆形为主的形态学特征;③特征性的纹层状构造;④核形石皮层中普遍发育而且较高密度保存的丝状蓝细菌鞘的钙化化石等等。尽管穿越成岩作用过滤器去解释古代核形石复杂的形成机理将存在着巨大的挑战,也尽管形成这些核形石复杂的生物膜钙化作用机理还没有得到精确的了解,但是,辽西葫芦岛三道沟剖面张夏组中的核形石,直接的微生物化石证据,尤其是在核形石内较为丰富的丝状蓝细菌鞘化石,使其成为一个了解光合作用生物膜建造核形石的典型实例;同时,也为进一步了解形成在水柱中的放射鲕粒以及形成在海底的泥晶核形石之间复杂的形成机理的差异性,提供了一个较为典型的实例。 | 梅冥相 Khalid Latif 孟晓庆 胡媛 | 2020 | 地质学报2020，94，4： | 12 |
| 5 | 光合作用生物膜建造的凝块:来自于辽东半岛芙蓉统长山组凝块石生物丘中的一些证据显示文摘作为一种以非纹层状组构而区别于叠层石的微生物碳酸盐岩类型,中凝块(mesoclots)是产生凝块石凝块组构关键的微结构。构成这种中凝块的离散性凝块状泥晶,似乎代表了细胞外聚合物质(EPS)复杂的钙化作用,但是,由于常常缺乏直接的微生物证据,造成其所涉及的准确成因和特殊过程还不太清楚。在辽东半岛大连金州湾和本溪田师傅剖面芙蓉统下部的长山组顶部,发育较为典型的凝块石生物丘,组成三级层序的强迫型海退体系域沉积,代表着较为壮观的沉积学现象;在这些凝块石生物丘中,毫米级别大小的暗色离散性凝块状泥晶是其最为基本的沉积组构,而且在这些凝块之中以较高密度保存的丝状蓝细菌鞘化石反映的微生物构成,意味着它们具有明显的光合作用生物膜成因。尽管穿越成岩作用过滤器去解释古代凝块石复杂的形成机理将存在着巨大的挑战,也尽管形成这些凝块石复杂的生物膜钙化作用细节需要更加深入的研究才能得到更好的了解,但是,辽东半岛芙蓉统长山组的凝块石,尤其是在凝块内较为丰富的钙化蓝细菌鞘化石所表征的直接的微生物活动证据,使其成为一个了解光合作用生物膜建造凝块的典型实例;再者,与凝块共生的三叶虫化石、底栖鲕粒和皮壳粒,以及围绕着这些多样化颗粒特别的放射纤维状方解石结壳,说明这些凝块石可能属于较厚的微生物席内多重状生物膜以及构成这些微生物席和微生物膜的细胞外聚合物质复杂的钙化作用建造物。 | 梅冥相 Khalid Latif 刘丽 孟庆芬 | 2019 | 古地理学报2019，21，2： | 12 |
| 6 | 寒武纪芙蓉统均一石沉积组构及环境特征——以河北涞源长山组为例显示文摘均一石以隐晶质岩性、无纹层与凝块结构发育为特征,与叠层石、凝块石、树形石并列为典型的微生物岩。然而,由于均一石在1995年命名以来很少在地层记录中得到识别和描述,并且缺乏现代实例的类比物,使得关于均一石的报道极具研究价值。为研究华北地台寒武系均一石沉积组构与形成环境特征,系统性地针对河北涞源祁家峪剖面芙蓉统长山组均一石生物丘进行研究。芙蓉统长山组从下部陆棚相钙质泥岩向上变浅至浅缓坡相厚层块状泥晶灰岩,组成了一个淹没不整合型三级层序。三级层序顶部的浅缓坡相厚层块状泥晶灰岩层,代表强迫型海退过程沉积,其内部发育一系列米级均一石生物丘。研究结果表明,这些生物丘主体为致密泥晶及少量微量晶组成,其中可见到附枝菌(Epiphyton)、葛万菌(Girvanella)、肾形菌(Renalcis)等钙化微生物化石。这些钙化微生物(蓝细菌)化石的出现,代表了显生宙第一幕蓝细菌钙化作用事件的证据,同时间接的说明均一石生物丘形成于蓝细菌主导的微生物席的钙化作用过程之中。同时,生物丘内还局部集中发育底栖鲕粒与草莓状黄铁矿颗粒,表明了生物丘形成过程中复杂的微生物沉积作用机制。因此,河北涞源长山组顶部的均一石生物丘,尽管泥晶和微亮晶是其基本构成,但是各种钙化蓝细菌化石以及底栖鲕粒与草莓状黄铁矿颗粒的局部出现表明了在蓝细菌主导的微生物席中复杂的微生物活动信号,成为了解生物丘形成机制、显生宙第一幕蓝细菌钙化作用事件的典型实例。 | 肖恩照 王皓 覃英伦 Khalid Latif Muhammad Riaz | 2020 | 沉积学报2020，38，1： | 11 |
| 7 | 免耕与秸秆还田对中国农田固碳和作物产量的影响显示文摘为明确免耕与秸秆还田对中国农田固碳和作物产量的影响,基于1995-2019年公开发表文献中的1 162对研究数据,综合分析免耕和秸秆还田的农田生态及生产效应。结果表明,在全国(不包括香港和澳门特别行政区、台湾省)范围内,仅考虑耕作影响,以翻耕为对照,免耕试验中,占比75.00%的试验研究表现出固碳速率提高,占比42.70%的试验研究表现出增产;仅考虑秸秆影响,以秸秆不还田为对照,秸秆还田试验中占比88.23%的试验表现出固碳速率提高,占比79.80%的试验表现出增产。与传统方式相比,免耕与秸秆还田技术充分推广后,其固碳潜力可分别增至2.22×10^10和7.00×10^10 kg/年,增幅分别为63.90%和7.00%;全国主要粮食作物总产量分别增加-1.16%和3.72%。回归分析表明,免耕对作物产量和有机碳的影响分别与平均气温极显著相关,与土壤粘粒含量显著相关;秸秆还田对作物产量的影响与试验年限显著相关,与土壤pH极显著相关,而对有机碳的影响则与粘粒含量和土壤pH显著相关。总体上,免耕和秸秆还田可明显提高土壤的固碳能力,但存在地域上的差异,免耕和秸秆还田相对传统耕作在区域Ⅰ、区域Ⅱ和区域Ⅳ等区域表现为固碳速率提高。未来应进一步挖掘免耕与秸秆还田的互作效应,进一步增强农田生态效益,提高作物产量。 | 张雄智 李帅帅 刘冰洋 张云 Ahmad Latif Virk 王兴 赵鑫 张海林 | 2020 | 中国农业大学学报2020，25，5： | 11 |
| 8 | 吕梁山东北缘寒武系层序地层划分--以文水苍尔会剖面为例显示文摘为研究山西吕梁山地区寒武纪地层的地层学与沉积学问题,根据山西文水苍尔会剖面寒武系地层叠置关系,将该剖面寒武系地层划分为8个三级层序。基于沉积相的变化规律和地层叠置关系的旋回性研究结果,苍尔会剖面存在两个特殊的地层学与沉积学现象:下部为霍山组砂岩直接覆盖在太古宙变质岩系上,其较为良好的出露与明显的地层接触关系,为探讨山西中部霍山组砂岩的地层归属问题提供依据;在该剖面崮山组、长山组、凤山组中分别发育不同的均一石生物丘,代表华北地台寒武纪晚期—奥陶纪中期'随着后生动物辐射,微生物碳酸盐也在增加'微生物碳酸盐复苏期的基本沉积样式。在新的寒武纪年代地层框架下,对山西文水苍尔会剖面进行层序地层划分,不但为研究华北寒武系生物丘沉积组构多样性提供参考实例,同时也为探讨山西中部地区前寒武—寒武巨大的古地理变迁提供实例。 | 肖恩照 覃英伦 Muhammad Riaz Khalid Latif 姚琳 王皓 | 2017 | 东北石油大学学报2017，41，5： | 10 |
| 9 | Design and Implementation of Cloud Platform for Intelligent Logistics in the Trend of Intellectualization显示文摘Intellectualization has become a new trend for telecom industry, driven by intelligent technology including cloud computing, big data, and Internet of things. In order to satisfy the service demand of intelligent logistics, this paper designed an intelligent logistics platform containing the main applications such as e-commerce, self-service transceiver, big data analysis, path location and distribution optimization. The intelligent logistics service platform has been built based on cloud computing to collect, store and handling multi-source heterogeneous mass data from sensors, RFID electronic tag, vehicle terminals and APP, so that the open-access cloud services including distribution, positioning, navigation, scheduling and other data services can be provided for the logistics distribution applications. And then the architecture of intelligent logistics cloud platform containing software layer(SaaS), platform layer(PaaS) and infrastructure(IaaS) has been constructed accordance with the core technology relative high concurrent processing technique, heterogeneous terminal data access, encapsulation and data mining. Therefore, intelligent logistics cloud platform can be carried out by the service mode for implementation to accelerate the construction of the symbiotic win-winlogistics ecological system and the benign development of the ICT industry in the trend of intellectualization in China. | Mengke Yang Movahedipour Mahmood Xiaoguang Zhou Salam Shafaq Latif Zahid | 2017 | China Communications2017，14，10： | 9 |
| 10 | 微生物白云岩形成机制研究进展与存在问题显示文摘近年来,有关微生物白云岩沉淀作用机制的研究拓宽了沉积学中'白云岩问题'研究的视角。硫酸盐还原反应、产甲烷作用、有机分子水解等一系列可促进沉淀白云石的微生物代谢机制的发现,延伸了微生物白云石(岩)形成模式;有关可溶解硫化物催化白云石沉淀的研究,不但强调了硫酸盐还原反应机制,也为重新认识硫酸盐还原反应促进白云石沉淀机理提供了新线索。在现代环境中,微生物席内的原生白云石沉淀的发现,将微生物过程引入地表环境原生白云石沉淀作用和机理的研究,可能为寻找地层记录中的微生物白云石提供了更多有益的工作手段和思考途径。然而更加复杂的白云岩地层记录说明,运用微生物白云石去解释复杂的地质记录还存在着较多的局限性。 | 肖恩照 隋明园 Khalid Latif Muhammad Riaz | 2017 | 大庆石油地质与开发2017，36，2： | 8 |
| 11 | 河北涞源祁家峪剖面寒武系层序地层划分显示文摘河北涞源祁家峪剖面寒武系出露连续,层序界面清楚且沉积现象丰富,是进行华北地台寒武系层序划分的较为典型的剖面之一。在新的寒武系年代地层框架下,依据地层的叠置形式、纵向上的沉积相变化及其内部的旋回特征,将该剖面寒武系划分为8个三级层序。结果表明:研究区域从馒头组、毛庄组的'TST+HST'沉积序列转变为'CS+HST'的淹没不整合型层序序列,反映出从混积潮坪沉积序列向缓坡型碳酸盐台地的演化过程,也意味着华北地台寒武系碳酸盐台地从发展阶段向成熟阶段的重大转变;该剖面芙蓉统内部的竹叶状灰岩与长山组顶部、凤山组第1个三级层序顶部发育的均一石生物丘代表了华北地台寒武系末期'贫乏骨骼的风暴海'以及'随着后生动物辐射,微生物碳酸盐岩也在增加'两大特殊沉积现象较为典型的沉积样式。基于层序地层框架内的沉积相叠加方式和地层记录中旋回特征的描述,对河北涞源祁家峪剖面进行层序地层划分,将为探索华北地台在太行山北缘广泛分布的寒武系提供参考实例,也为今后更大区域范围的对比研究提供线索。 | 肖恩照 隋明园 覃英伦 Khalid Latif Muhammad Riaz 王皓 | 2017 | 大庆石油地质与开发2017，36，6： | 7 |
| 12 | 药用植物内生菌对作物生长及氧化应激的作用(英文)显示文摘目的:探讨药用植物内生菌的多样性及其在种子生长和氧化应激中的作用。方法:从三种药用植物(Caralluma acutangula、Rhazya stricta和Moringa peregrina)中提取内生菌;基于18S r DNA测序和系统发育分析鉴定分离得到的内生菌株;以正常和矮化突变体水稻品系为对照,比较不同浓度的内生菌培养滤液(CF)对水稻种子的发芽和生长的影响;通过气相色谱-质谱分析CF中的有效活性成分。结论:从药用植物中共获得10种内生菌,包括茎点霉属6株、链格孢属2株、双极霉属1株和枝孢霉属1株。CF表现出剂量依赖性的生长刺激和抑制作用。与对照和其他内生菌相比,100%的茎点霉菌CF显著促进了水稻种子的发芽和生长;双极霉中的吲哚乙酸含量最高,并表现出比其更高的自由基清除和抗脂质过氧化活性;双极霉菌和茎点霉菌的类黄酮和酚类成分较高。综上所述,药用植物中存在内生菌株,其可以用于改善作物生长和减轻氧化应激。 | Abdul Latif KHAN Syed Abdullah GILANI Muhammad WAQAS Khadija AL-HOSNI Salima AL-KHIZIRI Yoon-Ha KIM Liaqat ALI Sang-Mo KANG Sajjad ASAF Raheem SHAHZAD Javid HUSSAIN In-Jung LEE Ahmed AL-HARRASI | 2017 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2017，18，2： | 6 |
| 13 | 持续高温胁迫环境下内生菌产生植物激素和有机酸促进粳稻生长的研究(英文)显示文摘目的:研究在高温胁迫环境下内生菌(Paecilomyces formosus LWL1)对粳稻生长的影响。创新点:首次探讨P.formosus LWL1产生的植物激素和有机酸在缓解粳稻热应激方面的作用。方法:比较正常和高温胁迫两种环境下,P.formosus LWL1对Dongjin粳稻植株的生长状况及内源性脱落酸、茉莉酸和总蛋白水平变化的作用。结论:内生菌在正常和高温胁迫条件下均能显著提高植物生长情况,包括株高、鲜重、干重和叶绿素含量。内生菌组的植株具有更低的内源性胁迫信号化合物水平及提升的总蛋白量,表明其具有保护粳稻的作用。这种内生菌可能有利于作物在高温环境下生长的耐受性。 | Muhammad WAQAS Abdul Latif KHAN Raheem SHAHZAD Ihsan ULLAH Abdur Rahim KHAN In-Jung LEE | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，12： | 5 |
| 14 | 共沉淀体系用于自来水中铬的分离和富集显示文摘通过氢氧化镝与Cr(III)离子的共沉淀来分离Cr(III)、C(rⅥ),并测定总含铬量的方法应用于自来水样本中。Cr(III)离子经该方法可定量回收,而C(rⅥ)离子的回收值则低于10%。实验研究了影响定量沉淀因素,包括氢氧化镝的量和pH值,离心速度和定量沉淀实验的取样体积。没有发现碱金属、碱土金属和其他过渡金属离子对待测离子的分析产生阻碍。本实验的检测极限(k=3,N=15)分别为Cr(III)0.65g/L和C(rⅥ)0.78g/L。 | Ashhan Karatepea Esra Korkmaz Mustafa Soylak Latif Elci 李晨英 陈华林 刘白玲 罗荣 刘明华 | 2012 | 西部皮革2012，34，2： | 5 |
| 15 | Combined and synergistic effects of climate change and urbanization on water quality in the Wolf Bay watershed,southern Alabama显示文摘This study investigated potential changes in flow, total suspended solid(TSS) and nutrient(nitrogen and phosphorous) loadings under future climate change, land use/cover(LULC)change and combined change scenarios in the Wolf Bay watershed, southern Alabama,USA. Four Global Circulation Models(GCMs) under three Special Report Emission Scenarios(SRES) of greenhouse gas were used to assess the future climate change(2016–2040). Three projected LULC maps(2030) were employed to reflect different extents of urbanization in future. The individual, combined and synergistic impacts of LULC and climate change on water quantity/quality were analyzed by the Soil and Water Assessment Tool(SWAT).Under the 'climate change only' scenario, monthly distribution and projected variation of TSS are expected to follow a pattern similar to streamflow. Nutrients are influenced both by flow and management practices. The variation of Total Nitrogen(TN) and Total Phosphorous(TP) generally follow the flow trend as well. No evident difference in the N:P ratio was projected. Under the 'LULC change only' scenario, TN was projected to decrease,mainly due to the shrinkage of croplands. TP will increase in fall and winter. The N:P ratio shows a strong decreasing potential. Under the 'combined change' scenario, LULC and climate change effect were considered simultaneously. Results indicate that if future loadings are expected to increase/decrease under any individual scenario, then the combined change will intensify that trend. Conversely, if their effects are in opposite directions, an offsetting effect occurs. Science-based management practices are needed to reduce nutrient loadings to the Bay. | Ruoyu Wang Latif Kalin | 2018 | Journal of Environmental Sciences2018，30，2： | 5 |
| 16 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 17 | Cryptosporidiosis as threatening health problem:A review显示文摘The protozoa under the genus Cryplosporidium is a zoonotic apicomplexan obligate intracellular parasite.Cryptosporidiosis,the term used to designate infection caused by Cryptosporidium sp.,is considered as one of the most common food and waterborne diseases with worldwide spread,acting as a common cause of diarrhoea in animals and man.In immunocompetent individuals,Cryptosporidium typically induces self-limiting diarrhoea,which may resolve on its own after 2-3d.However,cryptosporidiosis may turn life-threatening and subsequently lead to death in small children,the elderly and immunocompromised person,especially in AIDS patient.The diagnosis for Cryptosporidium infection is usually carried out through examination of stool for the presence of oocysts which measured 4-6μm with spherical appearance.Morphometric identification is often difficult because of the diminutive size and obscure internal structure of the protozoa.Often,the identification of Cryptosporidium is realised through the combination of methods incorporating data from morphometries,molecular techniques,and host specificity.However,limitations to some of these techniques still exist whether because of eost,duration,expertise,or reliability.Drugs combination is implemented in treatment of cryptosporidiosis.The efficiency of paromomycin,an aminocyclitol antibiotic isolated from Streptomyces,can be effective when combined use with protease inhibitors or recombinant IL-12.Since there is no drug that achieves the complete removal of Cryptosporidium from the host,supportive therapy was preferred in both human and domestic animals. | Nurul Fariza Rossle Baha Latif | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，11： | 3 |
| 18 | Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice显示文摘AIM:To study the possible interactions of metoclopramide,domperidone and erythromycin in streptozotocin-induced diabetic mice treated with insulin by various parameters.METHODS:Effects of the individual as well as combined drugs were studied in diabetic mice via estimation of the blood glucose and serum insulin levels,small intestinal transit(SIT),gastric emptying(GE),xylose absorption and glucose tolerance tests.Groups were given insulin 2 IU/kg s.c.,metoclopramide 20 mg/kg p.o.,domperidone 20 mg/kg p.o.and erythromycin 6 mg/kg p.o.individually and in combination.There were also normal and diabetic control groups.The first set of experiments was carried out to investigate the subchronic effect on blood glucose and serum insulin levels in diabetic mice of one week of daily dose administration of the tested drugs individually as well as the combination of insulin with each prokinetic drug.The other five sets of experiments were carried out to investigate the acute effect of a single dose of each drug individually and in combination on blood glucose and serum insulin levels,SIT,GE,oral xylose absorption and glucose tolerance tests.RESULTS:The study included the prokinetic drugs metoclopramide(20 mg/kg),domperidone(20 mg/kg) and erythromycin(6 mg/kg),as well as insulin(2 IU/kg),which was individually effective in decreasing SIT,enhancing GE and increasing xylose absorption significantly in diabetic mice.Erythromycin tended to decrease blood glucose level and increase serum insulin level after 1 wk of daily administration in diabetic mice.Erythromycin potentiated the effect of insulin on blood glucose level and serum insulin level whereas other prokinetic agents failed to do so after repeated dose administration in diabetic mice.Metoclopramide or erythromycin in combination with insulin significantly decreased SIT,in diabetic mice,to lower levels than with insulin alone.Administration of prokinetic drugs along with insulin antagonized the action of insulin on xylose absorption.These combinations also increased the rate of glucose absorption from the gut.CONCLUSION:The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients,matched to the action of exogenous insulin.The use of prokinetics,such as erythromycin,may be interesting in the clinic in decreasing the need for insulin in diabetic patients.The dose of insulin may be safely decreased with erythromycin in chronic treatments. | Mohamed A Fouad Shalaby Hekma A Abd El Latif Mostafa E El Sayed | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 3 |
| 19 | Determination of calorie and protein intake among acute and sub-acute traumatic brain injury patients显示文摘Purpose:Malnutrition is a common problem among hospitalized patients,especially among traumatic brain injury(TBI)patients.It is developed from hypermetabolism and the condition may worsen under the circumstance of underfeeding or incompatible dietary management.However,the data of nutrient intake especially calorie and protein among TBI patients were scarce.Hence,this study aimed to determine the calorie and protein intake among acute and sub-acute TBI patients receiving medical nutrition therapy in hospital Sultanah Nur Zahirah,Terengganu.Methods:This observational study involved 50 patients recruited from the neurosurgical ward.Method of 24 h dietary recall was utilized and combined with self-administered food diaries for 2-8 days.Food consumptions including calorie intake and protein intake were analyzed using Nutritionist PRO™(Woodinville,USA)and manual calculation based on the Malaysian food composition database(2015).Results:Patients consisted of 56%males and 44%females with the median age of 28.0(IQR=22.8-36.5)years,of which 92%were diagnosed as mild TBI and the remaining(8%)as moderate TBI.The Glasgow coma scale(GCS)was adopted to classify TBI severity with the score 13-15 being mild and 9-12 being moderate.The median length of hospital stay was 2(IQR=2.0e3.3)days.Calorie and protein intake improved significantly from day 1 to discharge day.However,the intake during discharge day was still considered as suboptimal,i.e.75%of calorie requirement,whilst the median protein intake was only 61.3%relative to protein requirement.Moreover,the average percentages of calorie and protein intakes throughout hospitalization were remarkably lower,i.e.52.2%and 41.0%,respectively.Conclusion:Although the calorie and protein intakes had increased from baseline,hospitalized TBI patients were still at a risk to develop malnutrition as the average intakes were considerably low as compared to their requirements.Optimum nutrient intakes especially calorie and protein are crucial to ensure optimum recovery process as well as to minimize risks of infection and complications. | Mohd Ibrahim Abdullah Aryati Ahmad Sharifah Wajihah Wafa Syed Saadun Tarek Wafa Ahmad Zubaidi Abdul Latif Noor Aini Mohd Yusoff Muhammad Khalis Jasmiad Nujaimin Udin Kartini Abdul Karim | 2020 | Chinese Journal of Traumatology2020，23，5： | 3 |
| 20 | Twelve vegetables used for prevention and treatment of hemorrhoids in Persian Medicine显示文摘OBJECTIVE: To review the role of vegetables to prevent and treat hemorrhoids in Persian Medicine(PM).METHODS: We search main Persian Medicine manuscripts, including the books of Liber Continens,Canon of Medicine, Great Elixir, Akbarie’s Medicine,Storehouse of Medicaments and Present for the faithful. Also, it was considered by searching in reference books and published papers with the help of PubMed, Scopus, Google scholar databases.RESULTS: Twelve vegetables, relating to 8 plant families, have been found in PM that their effectiveness involved in laxative, anti-inflammation, antimicrobial, analgesic and wound healing.CONCLUSION: Our findings suggest that 12 Persian Medicine vegetables can be used to prevent and treat hemorrhoids. | Pouran Andarkhor Mahmood Khodadoost Mohammad Kamalinejad Ramin Talaie Latif Gachkar Arman Zargaran | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 3 |
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