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| 1 | Inhibition of the B7-H3 immune checkpoint limits tumor growth by enhancing cytotoxic lymphocyte function显示文摘在肿瘤和免疫系统之间的相互作用仍然糟糕被理解。重要临床的回答在对 CTLA4 和 PD-1/PD-L1 检查点与抗体对待的癌症病人被完成了;然而,仅仅病人的小部分对治疗作出回应,显示需要探索为癌症治疗的另外的 co 禁止的分子。B7-H3, B7 总科的一个成员,被我们以前显示出禁止 T 房间激活和 autoimmunity。在这研究,我们在肿瘤免疫分析了 B7-H3 的功能。B7-H3 的表示在多重肿瘤线,渗入肿瘤的树枝状的房间,和巨噬细胞被发现。与对抗抗体对待到 B7-H3 的 B7-H3-deficient 老鼠或老鼠显示出多重肿瘤的减少的生长,它取决于 NK 和 CD8 + T 房间。与细胞毒素的淋巴细胞表示的通常认为的受体, B7-H3 禁止了他们的激活,并且它的缺乏在忍受肿瘤的鼠标导致了增加的细胞毒素的淋巴细胞功能。B7-H3 和 PD-1 的联合封锁导致了迟了阶段的肿瘤的进一步提高的治疗学的控制。一起拿,我们的结果显示 B7-H3 检查点可以对癌症为免疫疗法用作一个新奇目标。 | Young-hee Lee Natalia Martin-Orozco Peilin Zheng Jing Li Peng Zhang Haidong Tan Hyun Jung Park Mira Jeong Seon Hee Chang Byung-Seok Kim Wei Xiong Wenjuan Zang Li Guo Yang Liu Zhong-jun Dong Willem W Overwijk Patrick Hwu Qing Yi Larry Kwak Zhiying Yang Tak W Mak Wei-Li Laszlo G Radvanyi Ling Ni Dongfang Liu Chen Dong | 2017 | Cell Research2017，27，8： | 29 |
| 2 | Clinical predictors of intractable childhood epilepsy显示文摘 | Aithala G Laszlo S Joseph H | 2006 | J Psycho Res2006，61，： | 1 |
| 3 | Clinical activity of rituximab in gastric marginal zone nonHodgkin's lymphoma resistant to or not eligible for anti-Helicobacter pylori therapy显示文摘 | Martinelli G Laszlo D Ferreri AJ | 2005 | J Clin Oncol2005，23，9： | 1 |
| 4 | Characterization of activated carbons from waste materials by adsorption from aqueous solutions显示文摘 | Laszlo K Bota A Nagy L G | 1997 | Carbon1997，35，5： | 1 |
| 5 | Expression of cmg1,an exo-beta-1,3-glucanase gene from Coniothyrium minitans,increases during sclerotial parasitism显示文摘 | Giczey G Zottan K Laszlo F | 2001 | Applied and Environmental Microbioloty2001，67，2： | 1 |
| 6 | High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group 显示文摘 | Laszlo G S Ries R E Gudgeon C J | 2014 | Leukemia & lymphoma2014，55，12： | 1 |
| 7 | The Thyatiridae of Eurasia:including the Sundaland and New Guinea(Lepidoptera)显示文摘 | Laszlo G.M Ronkay G Ronkay L Witt T | | 0，，： | 1 |
| 8 | Computed tomography in pulmonary emphysema显示文摘 | GODDARD P R NICHOLSON E M LASZLO G | 1982 | Clin Radiol1982，33，4： | 1 |
| 9 | Identification of an alternative CTLA-4 ligand cnstimulatory for T cell activation显示文摘 | Hathcock KS Laszlo G Dickler HB | 1993 | Science1993，262，5135： | 1 |
| 10 | The contribution of respiratory function tests to clinical diagnosis 显示文摘 | LASZLO G LANCE GN LEWIS GTR | 1993 | Eur Respir J1993，6，： | 1 |
| 11 | Chinese herbs (Astraglus membraanaceus and Lonicera fiaponica) and boron en- hance the non - specific immune response of Nile tilapia (Oreochromis niloticus ) and resistance against Aeromonas hydrophia 显示文摘 | Laszlo A Yin G J Xu P | 2008 | Aquaculture2008，275，4： | 1 |
| 12 | Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention显示文摘 | Laszlo V Eva S Pal G | 2003 | Toxicol Lett2003，140，11： | 1 |
| 13 | The Thyatiridae of Eura- sia including the Sundaland and New Guinea (Lepidoptera) 显示文摘 | Laszlo G M Ronkay G Ronkay L | 2007 | Esperiana2007，13，： | 1 |
| 14 | Malignant lymphomaassociated autoimmune diseases-a descriptive epidemiological study显示文摘 | Laszlo V Lajos G Margit Z | 2002 | Rheumatol Iht2002，22，： | 1 |
| 15 | Microsatellite within genes and ESTs of common carp and their applicability in silver crucian carp显示文摘 | Yue G H Ho M Y Laszlo Orban | 2004 | Aquaculture2004，234，： | 1 |
| 16 | Chinese herbs (As-tragalus and Lonicera japonica) and boron enhance the non-specific immune response of Nile tilapia (Ore-ochromis niloticus) and resistance against Aeromonas hydrophila 显示文摘 | Laszlo Ardo Yin G J Xu P | 2008 | Aquaculture2008，275，1： | 1 |
| 17 | Identification of an altematire CTLA4 ligend costimulatory for T cell activation显示文摘 | Hathcock K S Laszlo G Dickler H B | 1993 | Science1993，262，5135： | 1 |
| 18 | Adding Distribution to a Workflow Management System显示文摘 | Laszlo B Robert E Herbert G | 1999 | Database and Expert Systems Applications1999，2，1： | 1 |
| 19 | A general mechanism of polycrystalline growth显示文摘 | Laszlo G Tamas P Tamas B | 2004 | Nature Material2004，，3： | 1 |
| 20 | BALB/c mice genetically suscepti- ble to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease pene- trance显示文摘 | Farkas B Boldizsar F Tarjanyi O Laszlo A Lin S M Hutas G | 2009 | Arthritis Res Ther2009，11，： | 1 |
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