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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Comparison of emissions and efficiency of a turbo-charged lean-burn natural gas and hythane-fuelled engine 显示文摘 | Larsen J F Wallace J S | 1997 | Journal of Engineering for Gas Turbines and Power Trans ASME1997，119，： | 1 |
| 3 | CTLA-4 in autoimmune diseases-a general susceptibility gene to autoimmunity显示文摘 | Kristiansen OP Larsen ZM Pociot F | 2000 | Genes Immun2000，1，3： | 1 |
| 4 | Joint PP and PS seismic inversion显示文摘 | Margrave G F Stewart R R Larsen J A | 2001 | The Leading Edge2001，20，： | 1 |
| 5 | Chemical stimulation of branching in deciduous tree fruit nursery stock with ethyl 5-(4-chlomphenyl)-2H-tetrazole-2- acetate显示文摘 | LARSEN F E | 1979 | Journal of the American Society for Horticultural Science1979，6，： | 1 |
| 6 | Measurements of the wind stress, heat flux, and turbulence intensity during storm con- ditions over the North Sea显示文摘 | Geernaert G L Larsen S E Hansen F | 1987 | Journal of Geophysical Research1987，92，13： | 1 |
| 7 | Effect of dietary selenium on the response of stressed and unstressed chickens to Escherichia coli challenge and antigen显示文摘 | Larsen C T Pierson F W Cross W B | 1997 | Biological Trace Elements Research1997，58，3： | 1 |
| 8 | Can passive prone, exlensions of the back prevent back problems?A randomized, controlled inlervention trial of 314 military conscripts显示文摘 | Larsen K Weidick F Leboeuf-Yde C | 2002 | Spine2002，27，： | 1 |
| 9 | Management of patients with fulminant hepatic failure and brain edema显示文摘 | Toftengi F Larsen FS | 2004 | Metab Brain Dis2004，19，34： | 1 |
| 10 | Wind turbulence characteristics study at the Stonecutters Bridge site: Part I-Mean wind and turbulence intensities显示文摘 | HUI M C H LARSEN A XIANG H F | 2009 | Journal of Wind Engineering and Industrial Aerodynamics2009，97，1： | 1 |
| 11 | DHA promotes the neuronal differentiation of rat neural stem cells transfected with GPR40 gene显示文摘 | Ma DX Zhang MM Larsen CP Xu F Hua W Yamashima T Mao Y Zhou LF | | 0，，： | 1 |
| 12 | Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adult显示文摘 | LARSEN N VOGENSEN F K VAN DEN BERG F W J | 2010 | PLoS One2010，5，2： | 1 |
| 13 | Costimulation blockade with belatacept in renal transplantation显示文摘 | Vinceuti F Larsen C Durrbach A | 2005 | N Engl J Med2005，353，： | 1 |
| 14 | Cerebral Herniation in Patients with Acute Liver Failure is Correlated with Arterial Ammonia Concentration显示文摘 | Clemmesen J O Larsen F S Kondrup J | 1999 | Hepatology1999，29，3： | 1 |
| 15 | The mussel pump: properties and modeling显示文摘 | Jφgensen C B Larsen P S Mφhlenberg F | 1988 | Mar Ecol Prog Ser1988，45，： | 1 |
| 16 | Congenital iris cyst,A case studied by light and electron microscopy显示文摘 | Hvidberg-Hansen J Larsen F | 1972 | Acta Ophthalmol1972，50，： | 1 |
| 17 | Mannose-binding lectin and its genetic variants显示文摘 | Garred P Larsen F Seyfarth J | 2006 | Genes lmmun2006，7，2： | 1 |
| 18 | Fate and transport of 17fl-estradiol in soil-water systems 显示文摘 | Casey F X M Larsen G L Hakk H | 2003 | Environ Sci Technol2003，37，11： | 1 |
| 19 | A micro-reflectance IR spectroscopy method for analyzing volatile species in basaltic,andesitic,phonolitic,and rhyolitic glasses显示文摘 | King P L Larsen J F | 2013 | American Mineralogist2013，98，： | 1 |
| 20 | Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein显示文摘 | Larsen F Madsen HO Sim RB | 2004 | J Biol Chem2004，279，21： | 1 |
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