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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Isoprene and its degradation products as strong ozone precursors in Insubria, Northern Italy显示文摘 | M Duane B Poma D Rembges C Astorga B.R Larsen | 2002 | Atmospheric Environment2002，，24： | 2 |
| 3 | Screening of selected pesticides for oestrogen rcceptor activation in vitro 显示文摘 | VINGGAARD A M BREINBOLT V LARSEN J C | 1999 | Food Addit Contam1999，16，12： | 1 |
| 4 | Daily meatal care for prevention of catheter-associated bacteriuria:results using frequent applications of polyantibiotic cream显示文摘 | Classen D C Larsen R A Burke J P | 1991 | Infect Control Hosp Epidemiol1991，12，3： | 1 |
| 5 | Critical chloride content in reinforced concrete-a review显示文摘 | Angst U Elsener B Larsen C K | 2009 | Cement and Concrete Research2009，39，12： | 1 |
| 6 | Use of large submerged chambers to measure sediment-- water interactions 显示文摘 | SONZOGNI W C LARSEN D P MALUEG K W | 1977 | Water Research1977，11，： | 1 |
| 7 | Risk assessment of chemicals in European traditional foods显示文摘 | Larsen J C | 2006 | Trends Food Sci Technol2006，17，9： | 1 |
| 8 | Priming the cow for mo-bilization in the periparturient period:effects of supplemen-ting the dry cow with saturated fat or linseed显示文摘 | Andersen J B Ridder C Larsen T | 2008 | J Dairy Sci2008，91，3： | 1 |
| 9 | Interleukin- 1-receptor antagonist in type 2 diabetes mellitus 显示文摘 | Larsen C M Faulenbach M Vaag A | 2007 | N Engl J Med2007，356，： | 1 |
| 10 | An analytical study of the Q(s,S) policy applied to the joint replenishment problem显示文摘 | Nielsen C Larsen C | | 0，，03： | 1 |
| 11 | Prevention of overuse injuries by a concurrent exercise program in subjects exposed to an increase in training load显示文摘 | Brushoj C Larsen K Albrecht Beste E | 2008 | Am J Sports Med2008，36，4： | 1 |
| 12 | A comparative study of psychiatric symptoms in dementia with Lewy bodies and Parkinson's disease with and without dementia显示文摘 | Ballard C Larsen JP | 2001 | Int J Geriatr Psychiatry2001，16，： | 1 |
| 13 | Suppressors of cytokine signaling:SOCS显示文摘 | Larsen L Ropke C | 2002 | APMIS2002，110，12： | 1 |
| 14 | Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell proliferation assay 显示文摘 | Breinhoh V Larsen J C | 1998 | Chemical Research in Toxicology1998，11，： | 1 |
| 15 | A randomized controlled trial of asoprisnil, a novel se- lective progesterone receptor modulator, in women with u- terine leiomyoma 显示文摘 | CHWALISZ K LARSEN L MATYIA-GOLDBERG C | 2007 | Fertility And Sterility2007，87，6： | 1 |
| 16 | Molecular identification and characterization of novel coronaviruses infecting graylag geese (Anser anser), feral pigeons (Columbia livia) and mallards (Anas platyrhynchos) 显示文摘 | Jonasseo C M Kofstad T Larsen I L | 2005 | J Gen Virol2005，86，： | 1 |
| 17 | Effects of temperature on the mussel pump显示文摘 | JOERGENSEN C B LARSEN P S RIISGAARD H U | 1990 | Mar Ecol Prog Ser1990，64，12： | 1 |
| 18 | Lipidated alpha- peptide/beta-peptoid hybrids with potent anti-inflammatory activity显示文摘 | Skovbakke S L Larsen C J Heegaard P M | 2015 | Journal of medicinal chemistry2015，，： | 1 |
| 19 | Membranous glomerulonephritis is a manifestation of IgG4-related disease 显示文摘 | Alexander M P Larsen C P Gibson I W | 2013 | Kidney international2013，83，3： | 1 |
| 20 | Tertiary picrites in West Greenland;melting at the periphery of a plume?显示文摘 | Gill R C Pedersen A K Larsen J G | 1992 | Geological Society Special Publications1992，68，： | 1 |
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