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| 1 | Physicochemical measurements in ‘Mondial Gala ? ’ apples stored at different atmospheres: Influence on consumer acceptability显示文摘 | G. Echeverría J. Graell I. Lara M.L. López | 2008 | Postharvest Biology and Technology2008，，2： | 2 |
| 2 | Emerging role of caldesmon in cancer:A potential biomarker for colorectal cancer and other cancers显示文摘Colorectal cancer(CRC) is a devastating disease, mainly because of metastasis. As a result, there is a need to better understand the molecular basis of invasion and metastasis and to identify new biomarkers and therapeutic targets to aid in managing these tumors. The actin cytoskeleton and actin-binding proteins are known to play an important role in the process of cancer metastasis because they control and execute essential steps in cell motility and contractility as well as cell division. Caldesmon(CaD) is an actin-binding protein encoded by the CALD1 gene as multiple transcripts that mainly encode two protein isoforms: High-molecular-weight CaD, expressed in smooth muscle, and low-molecular weight CaD(l-CaD), expressed in nonsmooth muscle cells. According to our comprehensive review of the literature, CaD, particularly l-CaD, plays a key role in the development, metastasis, and resistance to chemoradiotherapy in colorectal, breast, and urinary bladder cancers and gliomas, among other malignancies. CaD is involved in many aspects of the carcinogenic hallmarks, including epithelial mesenchymal transition via transforming growth factor-beta signaling, angiogenesis, resistance to hormonal therapy, and immune evasion. Recent data show that CaD is expressed in tumor cells as well as in stromal cells, such as cancerassociated fibroblasts, where it modulates the tumor microenvironment to favor the tumor. Interestingly, CaD undergoes selective tumor-specific splicing, and the resulting isoforms are generally not expressed in normal tissues, making these transcripts ideal targets for drug design. In this review, we will analyze these features of CaD with a focus on CRC and show how the currently available data qualify CaD as a potential candidate for targeted therapy in addition to its role in the diagnosis and prognosis of cancer. | Alya R Alnuaimi Vidhya A Nair Lara J Bou Malhab Eman Abu-Gharbieh Anu Vinod Ranade Gianfranco Pintus Mohamad Hamad Hauke Busch Jutta Kirfel Rifat Hamoudi Wael M Abdel-Rahman | 2022 | World Journal of Gastrointestinal Oncology2022，14，9： | 2 |
| 3 | Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents显示文摘The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert atmosphere.The effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron microscopy.Compared with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass content.Complete metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave bagasse.These results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing agent.Therefore,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking. | Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 4 | Trends in overall opportunistic illnesses, Pneumocystis carinii pneumonia, cerebral toxoplasmosis and Mycobacterium avium complex incidence rates over the 30 years of the HIV epidemic: a systematic review显示文摘 | Lara Coelho Valdiléa Gon?alves Veloso Beatriz Grinsztejn Paula Mendes Luz | 2013 | Brazilian Journal of Infectious Diseases2013，，： | 2 |
| 5 | N-acetyl-L-cysteine combined with mesalamine in the treatment of ulcerative colitis: Randomized,placebo-controlled pilot study显示文摘AIM: To evaluate the effectiveness and safety of oral N-acetyl-L-cysteine (NAC) co-administration with mesalamine in ulcerative colitis (UC) patients. METHODS: Thirty seven patients with mild to moderate UC were randomized to receive a four-wk course of oral mesalamine (2.4 g/d) plus N-acetyl-L-cysteine (0.8 g/d) (group A) or mesalamine plus placebo (group B). Patients were monitored using the Modified Truelove-Witts Severity Index (MTWSI). The primary endpoint was clinical remission (MTWSI ≤ 2) at 4 wk. Secondary endpoints were clinical response (defined as a reduction from baseline in the MTWSI of ≥ 2 points) and drug safety. The serum TNF-α, interleukin-6, interleukin-8 and MCP-1 were evaluated at baseline and at 4 wk of treatment. RESULTS: Analysis per-protocol criteria showed clinical remission rates of 63% and 50% after 4 wk treatment with mesalamine plus N-acetyl-L-cysteine (group A) and mesalamine plus placebo (group B) respectively (OR = 1.71; 95% CI: 0.46 to 6.36; P = 0.19; NNT = 7.7). Analysis of variance (ANOVA) of data indicated a significant reduction of MTWSI in group A (P = 0.046) with respect to basal condition without significant changes in the group B (P = 0.735) during treatment. Clinical responses were 66% (group A) vs 44% (group B) after 4 wk of treatment (OR = 2.5; 95% CI: 0.64 to 9.65; P = 0.11; NNT = 4.5). Clinical improvement in group A correlated with a decrease of IL-8 and MCP-1. Rates of adverse events did not differ significantly between both groups. CONCLUSION: In group A (oral NAC combined with mesalamine) contrarily to group B (mesalamine alone), the clinical improvement correlates with a decrease of chemokines such as MCP-1 and IL-8. NAC addition not produced any side effects. | Luis G Guijarro Jose Mate Javier P Gisbert Jose Luis Perez-Calle Ignacio Marín-Jimenez Encarna Arriaza Tomás Olleros Mario Delgado Maria S Castillejo David Prieto-Merino Venancio Gonzalez Lara Amado Salvador Pea | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 6 | Arrival time of halo coronal mass ejections in the vicinity of the earth显示文摘 | Michalek G Gopalswamy N Lara A | 2004 | Astron Astrophys2004，423，： | 1 |
| 7 | Involvement of the S-layer proteins Hpi and S1pA in the maintenance of cell integrity in Deinococcns radiodnrans Rl显示文摘 | Rotlifnss H Lara J C Sclnnid A K | 2006 | Microbiology2006，152，9： | 1 |
| 8 | Channel estintation using implicit training 显示文摘 | Orozvo- Lugo A G Lara M M M McLernon D C | 2004 | IEEE Transactions on Signal Processing2004，52，1： | 1 |
| 9 | Black liquor lignin biodegradation by Trametes elegans 显示文摘 | Lara M A R M Antonio J R Orlando J | 2003 | Intemation Biodeterioration & Biodegradation2003，52，3： | 1 |
| 10 | High ALTlevel predict viremia in anti-HCV-positive HD patients if a modi-fied normal range of ALT is applied显示文摘 | Espinosa M Martin-Malo A Alvarez de Lara MA | 2000 | Clin Nephrol2000，54，2： | 1 |
| 11 | Quaternary nannofossil biostratigraphy from ocean drilling program leg 189,Tasmanian Gateway显示文摘 | Stant S A Lara J McGonigal K L | | 0，，： | 1 |
| 12 | Effect of the cutting process on the fatigue behavior of press hardened and high strength dual phase steels 显示文摘 | Lara A Picas I Casellas D | 2013 | Journal of Materials Processing Technology2013，213，11： | 1 |
| 13 | In vivo suppression of precore mRNA synthesis is associated with mutations in the hepatitis B virus core promoter显示文摘 | Laras A Koskinas J Hadziyannis SJ | 2002 | Virology2002，295，： | 1 |
| 14 | Oligosaeeharides isolated from goat milk reduce intestinal in- flammation in a rat model of dextran sodium sulfate - induced coli- tis 显示文摘 | LARA - VILLOSLADA F DEBRAS E NIETO A et al | 2006 | ClinealNutritiou2006，25，3： | 1 |
| 15 | In-line solid-phase extraction preconcentration in capillary electrophoresis-tan-dem mass spectrometry for the multiresidue detec-tion of quinolones in meat by pressurized liquid ex-traction显示文摘 | LARA F J GARCIA-CAMPANA A M ALES-BARRERO F | 2008 | Electrophoresis2008，29，： | 1 |
| 16 | SeqTrim:a high-throughput pipeline for pre-processing any type of sequence read显示文摘 | Falgueras J Lara A J Fernández-Pozo N | 2010 | BMC Bioinformatics2010，11，1： | 1 |
| 17 | A UML profile for the con-ceptual modeling of structurally complex data : Easing human ef-fort in the KDD process 显示文摘 | Lara J Lizcano D Martinez A | 2014 | Information and Software Techno-logy2014，56，3： | 1 |
| 18 | A survey on human activity recognition using wearable sensors 显示文摘 | Lara O D Labrador M A | 2013 | IEEE Communications Surveys & Tu- torials2013，15，3： | 1 |
| 19 | Plasma concentration of biochemical markers in pre-eclampsia-eclampsia and its association with the severity of the disease显示文摘 | Chavarria Olarte ME Gonzalez Gleason A Lara Gonzalez AL etal | 2000 | Ginecol Obstet Mex2000，68，38539： | 1 |
| 20 | Concurrent chemoradiation strategies in the management of unresectable stage Ⅲ non-small-cell lung cancer显示文摘 | Lara PN Jr Goldberg Z Davies A | 2002 | Clin Lung Cancer2002，3，2： | 1 |
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