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| 1 | Mucor rouxii delta 9-desaturase gene is transcriptionally regulated during cell growth and by low temperature显示文摘 | Laoteng K Anjard C Rachadawong S | 1999 | Mol Cell Biol Res Commun1999，1，1： | 1 |
| 2 | 3D structure modeling of a transmembrane protein, fatty acid elongase 显示文摘 | Chumningan S Pornputtapong N Laoteng K | 2010 | Communications in Computer and Information Science2010，115，1： | 1 |
| 3 | Overexpression of acetyl-CoA carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha显示文摘 | RUENWAI R CHEEVADHANARAK S LAOTENG K | 2009 | Molecular Biotechnology2009，42，3： | 1 |
| 4 | △6-desaturase of Mucor rouxii with high similarity to plant △6-desaturase and its heterologous expression in Saccharomyces cerevis显示文摘 | LAOTENG K MANNONTARAT R | 2000 | Biochemical and Biophysical Research Communications2000，279，1： | 1 |
| 5 | Mechanisms controlling lipid accumulation and polyunsaturated fatty acid synthesis in oleaginous fungi显示文摘 | Laoteng K Certi k M Cheevadhanark S | 2011 | Chemical Papers2011，65，2： | 1 |
| 6 | Genetic modification of essential fatty acids biosynthesis in Hansenula polymorpha显示文摘 | Laoteng K Ruenwai R Tanticharoen M | 2005 | FEMS Microbiology Letters2005，245，： | 1 |
| 7 | Δ6-desaturases of Mucor rouxii with high similarity to plant Δ6-desaturases and its heterologous expression in Saccharomyces cerevisiae 显示文摘 | Laoteng K Mannontarat R Tanticharoen M | 2000 | Bichem Biophys Res Commun2000，279，1： | 1 |
| 8 | Heterologous production of polyunsaturated fatty acids in Saccharomyces cerevisiae causes a global transcriptional response resulting in reduced proteasomal activity and increased oxidative stress显示文摘 | RUENWAI R NEISS A LAOTENG K | | 0，，03： | 1 |
| 9 | Significance of fatty acid supplementation on profiles of cell growth, fatty acid, and gene expression of three desaturases in Mucor rouxii显示文摘 | Khoomrung S Laoteng K Jitsue S | 2008 | Applied Microbiology and Biotechnology2008，80，3： | 1 |
| 10 | Overexpression of acetyl-CoA carboxylase gene of Mucor rouxii enhanced fatty acid content in Hansenula polymorpha显示文摘 | Ruenwai R Cheevadhanarak S Laoteng K | 2009 | Mol Bioteehnol2009，42，3： | 1 |
| 11 | Overexpression of acetyl-CoA carboxylase gene of Mucor rouxii enhanced fatty acid content Hansenula polymorpha显示文摘 | Ruenwai R Cheevadhanarak S Laoteng K | 2009 | Mol Biotechnol2009，42，3： | 1 |
| 12 | Significance of fatty acid supplementation on profiles of cell growth, fatty acid, and gene expression of three desaturases in Mucor rouxii显示文摘 | KHOOMRUNG S LAOTENG K JITSUE S | 2008 | Appl Mierobiol Bioteelanol2008，80，3： | 1 |
| 13 | Delta (6)-desaturase of Mucor rouxii with high similarity to plant delta(6)-desaturase and its heterologous expression in Saccharomyces cerevisiae显示文摘 | LAOTENG K MANNONTARAT R TANTICHAROENM | 2000 | Biochem Biophys Res Commun2000，279，1： | 1 |
| 14 | Evaluation of inoculum performance for enhancing gamma linolenic acid product ion from Mucor rouxii显示文摘 | Jeennor S Laoteng K Tanticharoen | | 0，，04： | 1 |
| 15 | Overexpression of Acetyl-CoA Carboxylase Gene of Mucor rouxii Enhanced Fatty Acid Content in Hansenula polymorpha 显示文摘 | Ruenwai R Cheevadhanarak S Laoteng K | 2009 | Mol Biotechnol2009，42，3： | 1 |
| 16 | Promoter analysis of Mucor rouxii △9-desaturase: Its implication for transcriptional regulation in Saccharomyces cerevisiae 显示文摘 | Laoteng K Cheevadhanarak S Tanticharoen M | 2005 | Biochemical and Biophysical Research Communications2005，335，2： | 1 |
| 17 | Systematic development of biomass overproducing Scheffersomyces stipitis for high-cell-density fermentations显示文摘The development of economically feasible bio-based process requires efficient cell factories capable of producing the desired product at high titer under high-cell-density fermentation.Herein we present a combinatorial approach based on systems metabolic engineering and metabolic evolution for the development of efficient biomass-producing strain.Systems metabolic engineering guided by flux balance analysis(FBA)was first employed to rationally design mutant strains of Scheffersomyces stipitis with high biomass yield.By experimentally implementing these mutations,the biomass yield was improved by 30%in GPD1,25%in TKL1,30%in CIT1,and 44%in ZWF1 overexpressed mutants compared to wild-type.These designed mutants were further fine-tuned through metabolic evolution resulting in the maximal biomass yield of 0.49 g-cdw/g-glucose,whichmatcheswell with predicted yield phenotype.The constructed mutants are beneficial for biotechnology applications dealing with high cell titer cultivations.This work demonstrates a solid confirmation of systems metabolic engineering in combination with metabolic evolution approach for efficient strain development,which could assist in rapid optimization of cell factory for an economically viable and sustainable bio-based process. | Pornkamol Unrean Sukanya Jeennor Kobkul Laoteng Thailand Science Park Phahonyothin Road Klong Nueng Klong Luang Thailand | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 0 |
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