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| 1 | Effect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus:A review显示文摘Cardiovascular disease is the predominant cause of death in type 2 diabetes mellitus(T2DM).Evidence suggests a strong association between duration and degree of hyperglycemia and vascular disease.However,large trials failed to show cardiovascular benefit after intensive glycemic control,especially in patients with longer diabetes duration.Atherosclerosis is a chronic and progressive disease,with a long asymptomatic phase.Subclinical atherosclerosis,which is impaired in T2DM,includes impaired vasodilation,increased coronary artery calcification(CAC),carotid intima media thickness,arterial stiffness,and reduced arterial elasticity.Each of these alterations is represented by a marker of subclinical atherosclerosis,offering a cost-effective alternative compared to classic cardiac imaging.Their additional use on top of traditional risk assessment strengthens the predictive risk for developing coronary artery disease(CAD).We,herein,review the existing literature on the effect of glycemic control on each of these markers separately.Effective glycemic control,especially in earlier stages of the disease,attenuates progression of structural markers like intima-media thickness and CAC.Functional markers are improved after use of newer antidiabetic agents,such as incretin-based treatments or sodium-glucose cotransporter-2 inhibitors,especially in T2DM patients with shorter disease duration.Larger prospective trials are needed to enhance causal inferences of glycemic control on clinical endpoints of CAD. | Sofia Antoniou Katerina K K Naka Marios Papadakis Aris Bechlioulis Agathocles Tsatsoulis Lampros K Michalis Stelios Tigas | 2021 | World Journal of Diabetes2021，12，11： | 2 |
| 2 | Roadmapping as a knowledge creation process: the prolearn roadmap显示文摘 | VANA KAMTSIOU AMBJORN NAEVE LAMPROS K | 2006 | Journal of Universal Knowledge Management2006，1，3： | 1 |
| 3 | Exercise-mediated adaptations in vascular function and structure:Beneficial effects in coronary artery disease显示文摘Exercise exerts direct effects on the vasculature via the impact of hemodynamic forces on the endothelium,thereby leading to functional and structural adaptations that lower cardiovascular risk.The patterns of blood flow and endothelial shear stress during exercise lead to atheroprotective hemodynamic stimuli on the endothelium and contribute to adaptations in vascular function and structure.The structural adaptations observed in arterial lumen dimensions after prolonged exercise supplant the need for acute functional vasodilatation in case of an increase in endothelial shear stress due to repeated exercise bouts.In contrast,wall thickness is affected by rather systemic factors,such as transmural pressure modulated during exercise by generalized changes in blood pressure.Several mechanisms have been proposed to explain the exercise-induced benefits in patients with coronary artery disease(CAD).They include decreased progression of coronary plaques in CAD,recruitment of collaterals,enhanced blood rheological properties,improvement of vascular smooth muscle cell and endothelial function,and coronary blood flow.This review describes how exercise via alterations in hemodynamic factors influences vascular function and structure which contributes to cardiovascular risk reduction,and highlights which mechanisms are involved in the positive effects of exercise on CAD. | Xenofon M Sakellariou Michail I Papafaklis Eleni M Domouzoglou Christos S Katsouras Lampros K Michalis Katerina K Naka | 2021 | World Journal of Cardiology2021，13，9： | 1 |
| 4 | Explicit Window Adaptation: A Method to Enhance TCP Performance 显示文摘 | Lampros K Anujan V | 2002 | IEEE/ACM Transactions on Networking2002，10，3： | 1 |
| 5 | Explicit window adaptation:a method to enhance TCP performance 显示文摘 | Lampros K Anujan V | 2002 | IEEE/ACM Transactions on Networking2002，10，3： | 1 |
| 6 | Higher order nested Wigner distribution: properties and applications 显示文摘 | Saad A Q Lampros K S | 2006 | IEEE Transactions on Signal Processing (S1053-587X)2006，54，12： | 1 |
| 7 | Higher Order Nested Wigner Distribution: Properties and Applications显示文摘 | SAAD A Q LAMPROS K S | 2006 | IEEE Transactions on Signal Processing2006，54，12： | 1 |
| 8 | Apoptosis bcl-2 and nitrotyrosine expression in an angioplasty-restenosis rabbit: An experimental model 显示文摘 | Vassiliki D Malamou-Mitsib Lampros K | 2007 | Int J Surg2007，5，4： | 1 |
| 9 | Improving Routine Immunization Coverage Through Optimally Designed Predictive Models显示文摘Routine immunization(RI)of children is the most effective and timely public health intervention for decreasing child mortality rates around the globe.Pakistan being a low-and-middle-income-country(LMIC)has one of the highest child mortality rates in the world occurring mainly due to vaccine-preventable diseases(VPDs).For improving RI coverage,a critical need is to establish potential RI defaulters at an early stage,so that appropriate interventions can be targeted towards such populationwho are identified to be at risk of missing on their scheduled vaccine uptakes.In this paper,a machine learning(ML)based predictivemodel has been proposed to predict defaulting and non-defaulting children on upcoming immunization visits and examine the effect of its underlying contributing factors.The predictivemodel uses data obtained from Paigham-e-Sehat study having immunization records of 3,113 children.The design of predictive model is based on obtaining optimal results across accuracy,specificity,and sensitivity,to ensure model outcomes remain practically relevant to the problem addressed.Further optimization of predictive model is obtained through selection of significant features and removing data bias.Nine machine learning algorithms were applied for prediction of defaulting children for the next immunization visit.The results showed that the random forest model achieves the optimal accuracy of 81.9%with 83.6%sensitivity and 80.3%specificity.The main determinants of vaccination coverage were found to be vaccine coverage at birth,parental education,and socioeconomic conditions of the defaulting group.This information can assist relevant policy makers to take proactive and effective measures for developing evidence based targeted and timely interventions for defaulting children. | Fareeha Sameen Abdul Momin Kazi Majida Kazmi Munir A Abbasi Saad Ahmed Qazi Lampros K Stergioulas | 2022 | Computers, Materials & Continua2022，，1： | 0 |
| 10 | Elderly patients with non-cardiac admissions and elevated highsensitivity troponin:the prognostic value of renal function显示文摘BACKGROUND High-sensitivity cardiac troponin(hs-cTn)levels are frequently elevated in elderly patients presenting to the emergency department for non-cardiac events.However,most studies on the role of elevated hs-cTn in elderly populations have investigated the prognostic value of hs-cTn in patients with a specific diagnosis or have assessed the relationship between hs-cTn and comorbidities.AIM To investigate the in-hospital prognosis of consecutive elderly patients admitted to the Internal Medicine Department with acute non-cardiac events and increased hs-cTnI levels.METHODS In this retrospective study,we selected patients who were aged≥65 years and admitted to the Internal Medicine Department of our hospital between January 2019 and December 2019 for non-cardiac reasons.Eligible patients were those who had hs-cTnI concentrations≥100 ng/L.We investigated the independent predictors of in-hospital mortality by multivariable logistic regression analysis.RESULTS One hundred and forty-six patients(59%female)were selected with an age range from 65 to 100(mean±SD:85.4±7.61)years.The median hs-cTnI value was 284.2 ng/L.For 72(49%)patients the diagnosis of hospitalization was an infectious disease.The overall in-hospital mortality was 32%(47 patients).Individuals who died did not have higher hs-cTnI levels compared with those who were discharged alive(median:314.8 vs 282.5 ng/L;P=0.565).There was no difference in mortality in patients with infectious vs non-infectious disease(29%vs 35%).Multivariable analysis showed that age(OR 1.062 per 1 year increase,95%CI:1.000-1.127;P=0.048)and creatinine levels(OR 2.065 per 1 mg/dL increase,95%CI:1.383-3.085;P<0.001)were the only independent predictors of death.Mortality was 49%in patients with eGFR<30 mL/min/1.73 m2.CONCLUSION Myocardial injury is a malignant condition in elderly patients admitted to the hospital for non-cardiac reasons.The presence of severe renal impairment is a marker of extremely high in-hospital mortality. | Ioanna Samara Stavroula Tsiara Michail I Papafaklis Konstantinos Pappas Georgios Kolios Nikolaos Vryzas Lampros K Michalis Eleni T Bairaktari Christos S Katsouras | 2021 | World Journal of Cardiology2021，13，10： | 0 |
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