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| 1 | Role of matrix metalloproteinase,tissue inhibitor of metalloproteinase and tumor necrosis factor-α single nucleotide gene polymorphisms in inflammatory bowel disease显示文摘AIM:To study the (functional) relevance of single nucleotide polymorphisms (SNPs) in genes encoding matrix metalloproteinases (MMP)-1,-2,-3,-9,tissue inhibitors of metalloproteinases (TIMP)-1,-2 and tumor necrosis factor (TNF)-α in the etiopathogenesis of inflammatory bowel diseases (IBD),that may enhance susceptibility and/or disease severity. METHODS:Genomic DNA from 134 Crohn's disease (CD),111 ulcerative colitis (UC) patients and 248 control subjects was isolated from resected intestinal tissue or blood. Allelic composition at SNP loci was determined by PCR-RFLP or tetra primer ARMS PCR. RESULTS:The TIMP-1 genotype TT in women and T in men at SNP +372 T/C was found to increase CD susceptibility (39% vs 23.8%,P=0.018 and 67.9% vs 51.6%,P=0.055,respectively),while women with this genotype were less prone to development of fistulae during follow-up (41.4% vs 68.3%,P=0.025). Male IBD or CD patients carrying the TIMP-1 +372 T-allele expressed lower levels of TIMP-1 in surgically resected macroscopically inflamed tissue (0.065 < P < 0.01). The 5T5T genotype at MMP-3 SNP -1613 5T/6T increased the chance of stenotic complications in CD during follow-up (91.2% vs 71.8%,P = 0.022) but seemed to protect against colonic involvement of this disease at first endoscopic/radiologic examination (35.3% vs 59.5%,P=0.017). CONCLUSION:Allelic composition at the examinedSNPs in genes coding for TIMP-1 and MMP-3 affect CD susceptibility and/or phenotype,i.e.,fistulizing disease,stricture pathogenesis and first disease localisation. These findings reinforce the important role of these proteins in IBD. | Martin JW Meijer Marij AC Mieremet-Ooms Ruud A van Hogezand Cornelis BHW Lamers Daniel W Hommes Hein W Verspaget | 2007 | World Journal of Gastroenterology2007，13，21： | 15 |
| 2 | Angiogenic markers endoglin and vascular endothelial growth factor in gastroenteropancreatic neuroendocrine tumors显示文摘AIM:To investigate the expression and potential prognostic role of vascular endothelial growth factor(VEGF) and endoglin in gastroenteropancreatic neuroendocrine tumors(GEP-NETs) . METHODS:Microvessel density(MVD) in GEP-NETs was evaluated using endoglin and CD31 immunohistochemistry.In addition,tissue levels of endoglin and VEGF were determined in homogenates by ELISA. RESULTS:Endoglin was highly expressed on tumor endothelial cells.CD31 MVD in GEP-NETs was significantly higher compared to endoglin MVD(P<0.01) .Two-tofour-fold higher tissue levels of endoglin and VEGF were seen in tumors compared to associated normal tissue. This increased endoglin tissue expression in tumors was significantly related to tumor size(P<0.01) ,presence of metastases(P=0.04) ,and a more advanced tumor stage(P=0.02) ,whereas expression of VEGF was not. CONCLUSION:We suggest that endoglin is a potential marker to indicate and predict metastases,which might be useful in the post-resection therapeutic approach of patients with GEP-NETs. | Patricia Kuiper Lukas JAC Hawinkels Eveline SM de Jonge-Muller Izk Biemond Cornelis BHW Lamers Hein W Verspaget | 2011 | World Journal of Gastroenterology2011，17，2： | 4 |
| 3 | High level HIV-1 DNA concentrations in brain tissues differentiate patients with post-HAART AIDS dementia complex or cardiovascular disease from those with AIDS显示文摘Highly active antiretroviral treatment(HAART) has had a significant impact on survival of individuals with acquired immunodeficiency syndrome(AIDS);however,with the longer life-span of patients with AIDS,there is increasing prevalence of AIDS dementia complex(ADC) and other non-AIDS-defining illness,and cardiovascular diseases(CVD) are also common.The influence of these varied disease processes on HIV-1 DNA concentration in brain tissues has not been thoroughly assessed in the post-HAART era.The purpose of the current study is to clarify the impacts of ADC and other complications of HIV disease on the viral load in the brains in AIDS patients with post-HARRT.We examined autopsy specimens from the brains of thirteen patients who died from complications of AIDS with quantitative polymerase chain reaction(QPCR).All but one patient had received HAART prior to death since 1995.Two patients died with severe CVD,multiple cerebrovascular atherosclerosis(CVA) throughout the brain and five patients died with ADC.Six patients had no ADC/CVA.A QPCR was used to measure the presence of HIV-1 DNA in six brain tissues(meninges,frontal grey matter,frontal white matter,temporal subcortex,cerebellum and basal ganglia).In the post-HARRT era,for non-ADC/CVA patients,HIV-1 DNA concentration in brain tissues was statistically higher than that in patients with ADC.In a new finding,two patients who suffered from severe CVD,especially CVA,also had high concentrations of HIV-1 in brain compartments not showing ADC related changes.To our knowledge,this is the first report of a relationship between the CVA and HIV-1 viral burden in brain.The current observations suggest that HAART-resistant HIV reservoirs may survive within ADC lesions of the brain as well as the macrophage rich atherosclerosis,which needs to be confirmed by more AIDS cases with CVA. | GALLIGAN Derek C. LAMERS Susanna L. YU Stephanie SHAGRUN Lamia SALEMI Marco MCGRATH Michael S. | 2009 | Science China(Life Sciences)2009，52，7： | 3 |
| 4 | Cerebrospinal neuro-specific enolase, S-100 and myelin basic protein in neurological disorders显示文摘 | Lamers KJB van Engelen BGM Gabrels FJM | 1995 | Acta Neurol Scand1995，92，： | 2 |
| 5 | Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions in vivo显示文摘 | Cor H. J. Lamers Sabine C. L. Langeveld Corrien M. Groot-van Ruijven Reno Debets Stefan Sleijfer Jan Willem Gratama | | Cancer Immunology Immunotherapy0，，： | 2 |
| 6 | An evidence-based clinical guideline for the diagnosis and treatment of lumbar disc herniation with radiculopathy显示文摘 | D. Scott Kreiner Steven W. Hwang John E. Easa Daniel K. Resnick Jamie L. Baisden Shay Bess Charles H. Cho Michael J. DePalma Paul Dougherty Robert Fernand Gary Ghiselli Amgad S. Hanna Tim Lamer Anthony J. Lisi Daniel J. Mazanec Richard J. Meagher Robert C | 2014 | The Spine Journal2014，，： | 2 |
| 7 | Crohn’s Disease in the Elderly: A Comparison With Young Adults显示文摘 | M. J. Wagtmans H. W. Verspaget C. B.H.W. Lamers R. A. van Hogezand | 1998 | Journal of Clinical Gastroenterology1998，，： | 2 |
| 8 | Apoptosis in developing anthers and the role of ABA in this process during androgenesis in Hordeum vulgate L显示文摘 | WANG M HOEKSTRA S VAN BERGEN S LAMERS GEM OPPEDIJK B J VAN DER HEUDEN M W DE PRIESTER W SCHILPEROORT RA 1 | 1999 | Plant Mol Biol1999，39，： | 1 |
| 9 | Optimization of culture conditions for activation and large-scale expansion of human T lymphocytes for biospeciilc antibody-directed cellular immunotherapy 显示文摘 | Lamers CH Van DE Griend RJ Braakman E | 1992 | Cancer1992，51，2： | 1 |
| 10 | Baculoviral expression and characterization of rodent cathepsin S显示文摘 | Mason C S Lamers M B Henderson I M | 2001 | Protein Expression and Purication2001，23，： | 1 |
| 11 | Analysis of missed cleavage sites,tryptophan oxidation and N-terminal pyroglutamylation after ingel tryptic digestion显示文摘 | THIEDE B LAMER S MATTOW J | 2000 | Rapid Commun Mass Spectrom2000，14，6： | 1 |
| 12 | Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury 显示文摘 | Vos PE Lamers KJ Hendriks JC | 2004 | Neurology2004，62，8： | 1 |
| 13 | GFAP and S100B are biomarkers of traumatic brain injury: An observational cohort study显示文摘 | P.E. Vos B. Jacobs T.M.J.C. Andriessen K.J.B. Lamers G.F. Borm T. Beems M. Edwards C.F. Rosmalen J.L.M. Vissers | 2010 | Neurology2010，，20： | 1 |
| 14 | Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients显示文摘 | Lamers KJ Vos P Verbeek MM | 2003 | Brain Res Bull2003，61，3： | 1 |
| 15 | Hepatitis C vi- rus infection management in 2012 显示文摘 | VAN GULICK J J LAMERS MH DRENTH JP | 2012 | Panminerva Med2012，54，1： | 1 |
| 16 | Inositol, glycogen, insulin, and six nobelists显示文摘 | Lamer J | 2013 | J Biol Chem2013，288，12： | 1 |
| 17 | Protein S-100B, neu- ron-specific enolase ( NSE ) , myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients 显示文摘 | Lamers KJ Vos P Verbeek MM | 2003 | Brain Res Bull2003，61，3： | 1 |
| 18 | Library construction for next-generation sequencing: overviews and challenges 显示文摘 | HEAD S R KIYOMI K H LAMERE S A | 2014 | Biotechniques2014，56，2： | 1 |
| 19 | Lumbar spine pain originating from vertebralosteophytes 显示文摘 | LAMER TJ | 1999 | Reg Anesth Pain Med1999，24，4： | 1 |
| 20 | Influence of sorpriot, and diffusion of aroma compounds in silicone rubber on their extraction by pervaporation 显示文摘 | Lamer T Rohart M S Voilley A | 1994 | J Membr Sci1994，90，： | 1 |
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