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| 1 | Effect of age on aortic atherosclerosis显示文摘Objective To examine the association of atherosclerosis burden in the survivors of an asymptomatic elderly cohort study and its relationship to other coronary risk factors (specifically, age) by evaluating aortic atherosclerotic wall burden by magnetic resonance imaging (MRI). Methods A total of 312 participants in an ongoing observational cohort study underwent cardiac and descending thoracic aorta imaging by MRI. Maximum wall thickness was measured and the mean wall thickness calculated.Wall/outer wall ratio was used as a normalized wall index (NWI) adjusted for artery size difference among participants. Percent wall volume (PWV) was calculated as NWI ×100.Results In this asymptomatic cohort (mean age: 76 years), the mean (SD) aortic wall area andwall thicknesswere 222 ±45 mm2 and 2.7 ±0.4 mm, respectively. Maximum wall thickness was 3.4 ±0.6 mm, and PWV was 32% ±4%. Women appeared to have smaller wall area,but after correcting for their smaller artery size, had significantly higher PWV than men (P = 0.03). Older age was associatedwith larger wall area (P = 0.04 for trend) with similar PWVs. However, there were no statistically significant associations between standard risk factors,Framingham global risk, or metabolic syndrome status, therapy for cholesterol or hypertension, coronary or aortic calcium score, and the aortic wall burden. Aortic calcificationwas associated with coronary calcification. Conclusions Asymptomatic elderly in this cohort had a greater descending thoracic aortic wall volume that correlated with age, andwomen had a significantly increased PWV compared to men. In these survivors, the atherosclerotic aortic wall burden was not significantly associated with traditional risk factors or with coronary or aortic calcium scores or coronary calcium progression. Results suggest that age, or as yet unidentified risk factor(s), may be responsible for the increase in atherosclerosis. | Michael A. Chen Miwa Kawakubo Patrick M. Colletti Dongxiang Xu Laurie LaBree Dustin Robert Detrano Stanley P Azen Nathan D. Wong Xue-Qiao Zhao | 2013 | Journal of Geriatric Cardiology2013，10，2： | 6 |
| 2 | The role of carotid arterial intima-medla thickness in predicting clinical coronary events显示文摘 | Hodis H N Mack W J LaBree L | 1998 | Ann Intern Med1998，128，4： | 1 |
| 3 | Accumulation of NH2-terminal fragment of connective tissue growth factor in the vitreous of patients with proliferative diabetic retinopathy显示文摘 | Hinton DR Spee C He S Weitz S Usinger W LaBree L | 2004 | Diabetes Care2004，27，3： | 1 |
| 4 | Post-traumatic proliferative vitreoretinopathy, the epidemiologic profile, onset, risk factors, and visual outcome 显示文摘 | Cardillo J A Stout T Labree L | 1997 | Ophthalmology1997，104，7： | 1 |
| 5 | The role of carotid arterial intima-medical thickness in predicing clinical coronary events 显示文摘 | Hodis HN Mack WJ LaBree L | 1998 | Ann Intern Med1998，128，4： | 1 |
| 6 | Coronary artery calcium score combined with framingham score for risk prediction in asymptomatic individuals显示文摘 | Greenland P LaBree L Azen SP | 2004 | JAMA2004，291，2： | 1 |
| 7 | “Differences in overweightand obesity among children from migrant and nativeorigin:a systematic review of the European literature”显示文摘 | L J W Labree H vandeMheen | 2011 | Obesity Reviews2011，，12： | 1 |
| 8 | Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals 显示文摘 | Greenland P LaBree L Azen SP | 2004 | JAMA2004，291，： | 1 |
| 9 | Results of silicone oil removal in patients with cytomegalovirus retinitis related retinal detachments显示文摘 | Morrison VL LaBree LD Azen SP | 2005 | Am J Ophthalmol2005，140，： | 1 |
| 10 | Correlations between measures of atherosclerosis change using carotid ultra- sonography and coronary angiography显示文摘 | Mack WJ Labree L Liu C | 2000 | Atherosclero sis2000，150，2： | 1 |
| 11 | The role of carotid arterial intima- media thickness in predicting clinical coronary events 显示文摘 | Hodis HN Mack W J LaBree L | 1998 | Ann Intern Med1998，128，4： | 1 |
| 12 | The role of carotid artery intima-media thickness in predicting clinical cornary events 显示文摘 | Hodia HN Mack WJ LaBree L | 1998 | Ann Intern Med1998，128，4： | 1 |
| 13 | A randomized trial comparing mitomycin C and conjunctival autograft after excision of primary pterygium 显示文摘 | Chen PP Aniyasu RG Kaza V LaBree LD McDonnell PJ | 1995 | Am J Ophthalmol1995，120，2： | 1 |
| 14 | Correlations between measures of atherosclerosls change using carotid ultrasonngraphy and coronary angiography 显示文摘 | Mack W J LaBree L Liu C R | 2000 | Atherosclerosis2000，150，2： | 1 |
| 15 | Experience with the Baerveldt glaucoma implant in treating neovascular glaucoma显示文摘 | P.A. Sidoti T.R. Dunphy G. Baerveldt L. LaBree D.S. Minckler P.P. Lee D.K. Heuer | 1995 | Ophthalmology1995，，7： | 1 |
| 16 | Coronary Artery Calcium Score Combined with Framingham Score for Risk Prediction in Asymptomatic Individuals显示文摘 | Greenland P LaBree L Azen SP | 2004 | JAMA2004，291，2： | 1 |
| 17 | The role of carotid arterial intima-media thickness in predicting clinical coronary events显示文摘 | Hodis HN Mack WJ LaBree L | 1998 | Ann Intern Med1998，128，4： | 1 |
| 18 | Coronary artery calcium score combined with Framingham score for risk prediction in asymptomatic individuals显示文摘 | Greeland P LaBree L Azen SP | 2004 | JAMA2004，291，： | 1 |
| 19 | Correlations between measures of atherosclerosis change using carotid ultrasonography and coronary angiography显示文摘 | Mack WJ LaBree L Liu CR | | Atherosclerosis0，150，2： | 1 |
| 20 | Continuity and coordination of care during and after neonatal intensive care显示文摘 | Labree W Foets M Weisglas-Kuperus N | 2010 | J Child Health Care2010，14，3： | 1 |
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