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| 1 | “Autoinflammatory psoriasis”-genetics and biology of pustular psoriasis显示文摘Psoriasis is a chronic inflammatory skin condition that has a fairly wide range of clinical presentations.Plaque psoriasis,which is the most common manifestation of psoriasis,is located on one end of the spectrum,dominated by adaptive immune responses,whereas the rarer pustular psoriasis lies on the opposite end,dominated by innate and autoinflammatory immune responses.In recent years,genetic studies have identified six genetic variants that predispose to pustular psoriasis,and these have highlighted the role of IL-36 cytokines as central to pustular psoriasis pathogenesis.In this review,we discuss the presentation and clinical subtypes of pustular psoriasis,contribution of genetic predisposing variants,critical role of the IL-36 family of cytokines in disease pathophysiology,and treatment perspectives for pustular psoriasis.We further outline the application of appropriate mouse models for the study of pustular psoriasis and address the outstanding questions and issues related to our understanding of the mechanisms involved in pustular psoriasis. | Ranjitha Uppala Lam C.Tsoi Paul W.Harms Bo Wang Allison C.Billi Emanual Maverakis J.Michelle Kahlenberg Nicole L.Ward Johann E.Gudjonsson | 2021 | Cellular & Molecular Immunology2021，18，2： | 7 |
| 2 | The metabolic transition during disease following infection of Arabidopsis thaliana by Pseudomonas syringae pv. tomato显示文摘 | Jane L.Ward SilviaForcat ManfredBeckmann MarkBennett Sonia J.Miller John M.Baker Nathaniel D.Hawkins Cornelia P.Vermeer ChuanLu WanchangLin William M.Truman Michael H.Beale JohnDraper John W.Mansfield MurrayGrant | 2010 | The Plant Journal2010，，3： | 1 |
| 3 | Australian sugarcane soldier fly’s salivary gland transcriptome in response to starvation and feeding on sugarcane crops显示文摘The soldier fly is an endemic pest of sugarcane in Australia.Small numbers of larvae can cause significant damage to roots and reduce the crop yields.Little is known about the composition and function of the soldier fly salivary gland,its secretions,and their roles in insect—plant interactions.In this study,we performed transcriptome analysis of the salivary glands of starved and sugarcane root-fed soldier fly larvae.A total of 31119 highly expressed assembled contigs were identified in the salivary glands and almost 50%of them showed high levels of similarity to known proteins in Nr databases.Of all the obtained contigs,only 9727 sequences contain an open reading frame of over 100 amino acids.Around 31%of contigs were predicted to encode secretory proteins,including some digestive and detoxifying enzymes and potential effectors.Some known salivary secreted peptides such as serine protease,cysteine proteinase inhibitors,antimicrobial peptides and venom proteins were among the top 100 highly expressed genes.Differential gene expression analysis revealed significant modulation of 850 transcripts in salivary glands upon exposure to plant roots or starvation stress.Here,we identified some venom proteins which were significantly upregulated in the salivary glands of soldier fly larvae exposed to sugarcane roots.In other insects and nematodes some of these proteins have been used to manipulate host plant defense systems and facilitate the invasion of the host plant.These findings provide a further insight into the identification of potential effector proteins involved in soldier fly-sugarcane interactions. | Kayvan Etebari Karel R.Lindsay Andrew L.Ward Michael J.Furlong | 2020 | Insect Science2020，27，4： | 0 |
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