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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Stem cell therapy as an emerging paradigm for stroke ( STEPS) Ⅱ显示文摘Cell-based therapies represent a new therapeutic approach for stroke.In 2007,investigators from academia,industry leaders,and members of the National Institutes of Health crafted recommendations to facilitate the | Savitz SI Chopp M Deans R Carmichael ST Phinney D Wechsler L | 2011 | 中华神经外科疾病研究杂志2011，10，3： | 5 |
| 3 | Influence of Fe Addition on Products of Self-Propagating High-Temperature Synthesis Reaction in 3Ti-Si-2C System显示文摘Influence of Fe addition on products of self-propagating high-temperature synthesis (SHS) reaction in 3Ti-Si-2C system was investigated in the present study. Without Fe addition, Ti5Si3 and TiC are the dominant phases along with a small amount of Ti3SiC2 phase and unreacted C left in the final products. As Fe content ranges from 10% to 30%, the products consist of TiC, Ti5Si3, Fe2Ti and unreacted C, but no trace of Ti3SiC2 phase is detected. Furthermore, the amounts of both Fe2Ti and C phases increase with Fe content increasing. Addition of Fe has a great effect on the reaction route and significantly restrains the formation of Ti3SiC2 during the combustion synthesis process, and therefore, the SHS is not an effective fabrication technique to synthesize the ternary Ti3SiC2 ceramic in either 3Ti-Si-2C or Fe-3Ti-Si-2C system. Besides, without Fe addition, Ti5Si3 presents as the coarse irregular appearance with an obviously sintered morphology. In contrast, the shape of Ti5Si3 exhibits more and more spherical (cobblestone-like) and the surface becomes increasingly smooth, because the amount of liquids formed during the SHS reaction increases with the increase of Fe content. On the other hand, with Fe content increasing from 0 to 30 wt.%, the particulate size of TiC decreases from more than 5 μm to 1 μm or less, mainly due to the fact that the combustion temperature decreases with the increase of Fe content in the preforms. | Guan Q L Wang H Y Li S L Si W P Jiang Q C | 2009 | 稀有金属材料与工程2009，38，A03： | 2 |
| 4 | Holocene slip rate and paleoearthquake records of the Salt Lake segment of the Northern Zhongtiaoshan Fault, Shanxi Province显示文摘The Northern Zhongtiaoshan Fault is a major deep fault at the southern margin of the Yuncheng Basin. There have been few studies on the fault, and the historical earthquakes are few and weak. However, the intensity of activity on the fault should never be underestimated. Through interpretations of aerial images, topography measurements and excavation of trenches, this paper studied the fault distribution, the surface deformation and the activity of the normal fault south of Salt Lake near the city of Yuncheng. By tracing faults in the three trenches, it was found that there had been at least three large paleoseismic events, at 1–3.5, 3.6–4.4 and 7.4–8.8 ka BP. Employing 14 C dating, we determined the same gravel layers in the uplifted side and downthrown side. Making differential Global Positioning System measurements of the vertical difference and topographic profile, we obtained the mean slip rate of the Northern Zhongtiaoshan Fault since 24.7 ka BP(0.75±0.05 mm/a). Using the results of relevant studies, we calculated the possible vertical fault displacement of one earthquake(2.35 m) and obtained the recurrence interval of characteristic earthquakes as 2940–3360 a after dividing the displacement by the mean slip rate. | SI SuPei LI YouLi Lü ShengHua WANG YiRan | 2014 | Science China Earth Sciences2014，57，9： | 2 |
| 5 | Predicting the Nuclear Localization Signals of 107 Types of HPV L1 Proteins by Bioinformatic Analysis显示文摘In this study, 107 types of human papillomavirus (HPV) L1 protein sequences were obtained from available databases, and the nuclear localization signals (NLSs) of these HPV L1 proteins were analyzed and predicted by bioinformatic analysis. Out of the 107 types, the NLSs of 39 types were predicted by PredictNLS soft- ware (35 types of bipartite NLSs and 4 types of monopartite NLSs). The NLSs of the remaining HPV types were predicted according to the characteristics and the homology of the already predicted NLSs as well as the general rule of NLSs. According to the result, the NLSs of 107 types of HPV L1 proteins were classified into 15 categories. The different types of HPV L1 proteins in the same NLS cat- egory could share the similar or the same nucleocytoplasmic transport pathway. They might be used as the same target to prevent and treat different types of HPV infection. The results also showed that bioinformatic technology could be used to analyze and predict NLSs of proteins. | Jun Yang Yi-Li Wang Lü-Sheng Si | 2006 | Genomics, Proteomics & Bioinformatics2006，4，1： | 2 |
| 6 | Cobalt catalysts for Fischer–Tropsch synthesis: The effect of support,precipitant and pH value显示文摘In this report,Co-based catalysts supported on ZnO,Al_2O_3 and ZrO_2 as well as the ZrO_2 derived from different precipitants and different pH values were prepared by co-precipitation method.Their catalytic Fischer–Tropsch synthesis(FTS)performance was investigated in a fixed-bed reactor.The results revealed that Co catalyst supported on ZrO_2 exhibited better FTS catalytic performance than that supported on ZnO or Al_2O_3.For the Co/ZrO_2catalyst,different precipitants showed the following an activity order of NaOH>Na_2CO_3>NH_4OH,and the best pH value is 13.The catalysts were characterized by N_2adsorption–desorption,XRF,XRD,H_2-TPR,H_2-TPD and TEM.It was found that the main factor affecting the CO conversion of the catalyst was the amounts of low-temperature active adsorption sites.Moreover,the selectivity of C_5^+hydrocarbons had a positive relationship with the peak temperature of the weak hydrogen adsorption sites.The higher the peak temperature,the higher the C_5^+selectivity is. | zhenhua li mengyao si li xin renjie liu runxue liu jing lü | 2018 | Chinese Journal of Chemical Engineering2018，26，4： | 2 |
| 7 | Enhanced immunization after intranasal coadministration of Escherichia coli heat-labile enterotoxin B subunit and human papillomavirus 16-L1 DNA vaccine显示文摘 | WANG Jing ZHAO Chang-an WANG Kai ZHENG Jin WANG Yi-li SI Lü-sheng | 2006 | Chinese Medical Journal2006，，5： | 2 |
| 8 | 氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响显示文摘已证明氨氯地平可改善高血压患者的血管内皮功能,但左旋氨氯地平是否具有类似作用仍存在争议。该研究比较氨氯地平和左旋氨氯地平对高血压患者血管内皮功能的影响,应用体外细胞培养研究其相关作用机制。方法:该研究为一项随机、交叉试验。选取原发性高血压患者24例服用氨氯地平和左旋氨氯地平各6周, | He Y Si D Yang C Ni L Li B Ding M Yang P 罗冬梅 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 2 |
| 9 | In-situ stress measurement and stress distribution characteristics in underground coal mines in China显示文摘 | Kang H P Zhang X Si L P | 2010 | Engineering Geology2010，，116： | 1 |
| 10 | Statistical mechanics of com-plex networks显示文摘 | Albert R Barabási A L | 2002 | Reviews of Modern Physics2002，74，1： | 1 |
| 11 | Evolution of the socialnetwork of scientific collaborations显示文摘 | Barabási A L Albert R Jeong H | 1999 | Physical A1999，，： | 1 |
| 12 | Highly Efficient Neodymium: Yttrium Aluminum Garn et Laser End-pumped by a Semiconductor Laser Array显示文摘 | Si D L | 1985 | Appl Phys Lett1985，47，2： | 1 |
| 13 | Mean-field theory for scale-free random networks显示文摘 | Barabási A L Albert R Jeong H | 1999 | Physica A1999，，272： | 1 |
| 14 | Curcunain mediates presenilin- 1 activity to reduce 13-amyloid production in a model of Alzheimer's Disease显示文摘 | ZHANG X ZHANG H M SI L | 2011 | Pharmacological Reports2011，63，5： | 1 |
| 15 | Holocene climate changes in the monsoon/arid transition reflected by carbon concentration in Daihai Lake of Inner Mongolia显示文摘 | XIAOJ L WU J T SI B | | 0，，04： | 1 |
| 16 | Analysis of the immunological microenvironment at the tumor site in patients with non-small cell lung cancer显示文摘 | Rui Li Dominik Rüttinger Rong Li Lü-Sheng Si Yi-Li Wang | 2003 | Langenbeck’s Archives of Surgery2003，，6： | 1 |
| 17 | Large-scale analysis of KIT aberrations in Chinese patients with melanoma 显示文摘 | Kong Y Si L Zhu Y | 2011 | Clin Cancer Res2011，17，7： | 1 |
| 18 | Determi?nation of tetracyclines in pig and other meat samples using liquid chromatography coupled with diode array and tandem mass spectrometric detectors显示文摘 | T?lgyesi áá T?lgyesi L Békési K | 2014 | Meat Sci2014，96，13： | 1 |
| 19 | Understanding individual human mobility patterns显示文摘 | Gonzá lez M C Hidalgo C A Barabá si A L | 2008 | Nature2008，453，7196： | 1 |
| 20 | Translational contral of p27kipl accum ulation during the cell cycle 显示文摘 | Reed SI | 1996 | Science1996，271，5257： | 1 |
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