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| 1 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 2 | Sucrose-phosphate synthase and other sucrose metabolizing enzymes in fruit of various species 显示文摘 | Hubbard N L Pharr D M Huber S C | 1991 | Physiol Plant1991，82，： | 1 |
| 3 | Role of sucrose phosphate synthase in sucrose biosynthesis in ripening bananas and its relationship to the respiratory climacteric 显示文摘 | HUBBARD N L PARR D M HUBER S C | 1990 | Plant Physiol1990，94，1： | 1 |
| 4 | Differential response of nitrate reductase and sucrose phosphate synthase activation to inorganic and organic salts,in vitro and in situ显示文摘 | Huber S C Huber J L Kaider W M | 1994 | Plant Physiol1994，，92： | 1 |
| 5 | Preparative two-dimensional gel electrophoresis of membrane proteins显示文摘 | Pasquali C Fialka l Huber LA | 1997 | Electrophoresis1997，18，14： | 1 |
| 6 | Role of sucrose phosphate synthase in sucrose biosynthesis in ripening bananas and its relationship to the respiratory climacteric显示文摘 | HUBBARD N L PHARR D M HUBER S C | 1990 | Plant Physiol1990，94，： | 1 |
| 7 | Plant aromatic L-amino acid decarboxylases:evolution,biochemistry,regulation,and metabolic engineering applications显示文摘 | FACCHINI P J HUBER ALLANACH K L TARI L W | 2000 | Phytochemistry2000，54，2： | 1 |
| 8 | Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx 显示文摘 | Huber GF Fritzsche FR Zullig L | 2011 | IntJ Cancer2011，129，6： | 1 |
| 9 | Effect of valley switching and switching frequency limitation on line-current distortions of DCM/CCM boundary boost PFC converters 显示文摘 | HUBER L IRVING B T JOVANOVIC M M | 2009 | IEEE Trans on Power Electronics2009，24，2： | 1 |
| 10 | Modelling the long QT syndrome with induced pluripotent stem cells显示文摘 | Itzhaki I Maizels L Huber I | | 0，，7337： | 1 |
| 11 | Approach to high-resolution NMR in solids显示文摘 | Waugh J S Huber L M Haeberlen U | 1968 | Phys Rev Lett1968，20，： | 1 |
| 12 | Placental mesenchymal stem cells as potential autologous graft for pre - and perinatal neuroregeneration显示文摘 | Portmann L B Schoebeflein A Huber A | 2006 | Am J Obstet Gynecol2006，194，： | 1 |
| 13 | Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer显示文摘 | Hermann P C Huber S L Herrler T | 2007 | Cell Stem Cell2007，1，： | 1 |
| 14 | Renal function-estimation of glomerular filtration rate显示文摘 | Thomas L Huber AR | 2006 | Clin Chem Lab Med2006，44，11： | 1 |
| 15 | Adenosine and cAMP are potent inhibitors of the NF-κB pdownstream of immunoreceptors显示文摘 | Minguet S Huber M Rosenkranz L | 2005 | Eur J Immunol2005，35，1： | 1 |
| 16 | Variation among species in light activation of sucrose - phosphate synthase 显示文摘 | Huber S C Nielsen T H Huber J L A | 1989 | Plant and Cell Physiology1989，30，2： | 1 |
| 17 | Modeled sensitivity of upper thermocline properties to tropical cyclone winds and possible feedbacks on the Hadley circulation显示文摘 | Sriver R L Huber M | 2010 | Geophys Res Lett2010，37，10： | 1 |
| 18 | Relationship of Cytotoxie Groups in Organotin Molecules and the Effectiveness of the Compounds Against Leukemia显示文摘 | Sherman L R Huber F | 1988 | Appl Organomet Chem1988，2，1： | 1 |
| 19 | Shell-Side condensation heat transfer of R-134a-Part II: Enhanced tube performance显示文摘 | Huber J B Rewerts L E Pate M B | 1994 | ASHRAE Transactions1994，100，2： | 1 |
| 20 | Regulation of transendothelial neutrophil migration by endogenous interleukin 8 显示文摘 | Huber A R Kunker S L Todd R F | 1991 | Science1991，254，： | 1 |
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