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| 1 | Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk显示文摘AIM: To investigate the role that single nucleotide polymorphisms (SNPs) in the promoter of the tumour necrosis factor-alpha (TNF-α) gene play in the risk of inflammatory bowel diseases (IBDs) in a New Zealand population, in the context of international studies. METHODS: DNA samples from 388 patients with Crohn's disease (CD), 405 ulcerative colitis (UC), 27 indeterminate colitis (IC) and 201 randomly selected controls, from Canterbury, New Zealand were screened for 3 common polymorphisms in the TNF-α receptor: -238 G→A, -308 G→A and -857C→T, using a TaqmanR assay. A meta-analysis was performed on the data obtained on these polymorphisms combined with that from other published studies. RESULTS: Individuals carrying the -308 G/A allele had a significantly (OR = 1.91, χ2 = 17.36, P < 0.0001) increased risk of pancolitis, and a 1.57-fold increased risk (OR = 1.57, χ2 = 4.34, P = 0.037) of requiring a bowel resection in UC. Carrying the -857 C/T variant decreased the risk of ileocolonic CD (OR = 0.56, χ2 =4.32, P = 0.037), and the need for a bowel resection (OR = 0.59, χ2 = 4.85, P = 0.028). The risk of UC was reduced in individuals who were smokers at diagnosis, (OR = 0.48, χ2 = 4.86, P = 0.028). CONCLUSION: TNF-α is a key cytokine known to play a role in inflammatory response, and the locus for the gene is found in the IBD3 region on chromosome 6p21, known to be associated with an increased risk for IBD. The -308 G/A SNP in the TNF-α promoter is functional, and may account in part for the increased UC risk associated with the IBD3 genomic region. The -857 C/T SNP may decrease IBD risk in certain groups. Pharmaco- or nutrigenomic approaches may be desir- able for individuals with such affected genotypes. | Lynnette R Ferguson Claudia Huebner Ivonne Petermann Richard B Gearry Murray L Barclay Pieter Demmers Alan McCulloch Dug Yeo Han | 2008 | World Journal of Gastroenterology2008，14，29： | 7 |
| 2 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 3 | Cytotoxic CD8+ T cells and tissue resident memory cells in colorectal cancer based on microsatellite instability and BRAF status显示文摘BACKGROUND Recent studies in non-colorectal malignancy have associated T resident memory(T_(RM)) cells with improved patient survival. It is unknown if T_(RM) plays a role in colorectal cancer(CRC).AIM To examine the potential role of T_(RM) cells in providing immunogenicity in CRC stratified by microsatellite instability(MSI) and BRAF status.METHODS Patients with known MSI and BRAF mutation status were eligible for inclusion in this study. CRC tumour sections stained with haematoxylin and eosin were microscopically reviewed and the images scanned prior to assessment for location of invading edge and core of tumour. Sequential sections were prepared for quantitative multiplex immunohistochemistry(IHC) staining. Opal Multiplex IHC staining was performed with appropriate positive and negative controls and imaged using a standard fluorescent microscope fitted with a spectral scanning camera(Mantra) in conjunction with Mantra snap software. Images were unmixed and annotated in in Form 2.2.0. Statistical analysis was performed using Graphpad Prism Version 7 and Stata Version 15.RESULTS Seventy-two patients with known MSI and BRAF status were included in the study. All patients were assessed for MSI by IHC and high resolution capillary electrophoresis testing and 44 of these patients successfully underwent quantitative multiplex IHC staining. Overall, there was a statistically significant increase in CD8+ T_(RM) cells in the MSI(BRAF mutant and wild type) group over the microsatellite stable(MSS) group. There was a statistically significant difference in CD8+ T_(RM) between high level MSI(MSI-H):BRAF mutant [22.57, 95% confidence interval(CI): 14.31-30.84] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0076 and MSI-H:BRAF wild type [16.18(95%CI: 10.44-21.93)] vs MSS [8.031(95%CI: 4.698-11.36)], P = 0.0279. There was no statistically significant difference in CD8 T cells(both CD8+CD103-and CD8+CD103+T_(RM)) between MSI-H: BRAF mutant and wild type CRC.CONCLUSION This study has shown that CD8+ T_(RM) are found in greater abundance in MSI-H CRC, both BRAF mutant and MSI-H:BRAF wild type, when compared with their MSS counterpart. CD8+ T_(RM) may play a role in the immunogenicity in MSI-H CRC(BRAF mutant and BRAF wild type). Further studies should focus on the potential immunogenic qualities of T_(RM) cells and investigate potential immunotherapeutic approaches to improve treatment and survival associated with CRC. | James Wei Tatt Toh Angela L Ferguson Kevin J Spring Hema Mahajan Umaimainthan Palendira | 2021 | World Journal of Clinical Oncology2021，12，4： | 2 |
| 4 | Disease resistance and enzyme heterozygosity in rainbow trout显示文摘 | Ferguson M M Drahushchak L R | 1990 | Heredity1990，64，： | 2 |
| 5 | Extrusion of metal powders显示文摘 | Ferguson B L | 1991 | International Materials Reviews1991，36，2： | 1 |
| 6 | The wavelength of light governing intraocular immune reactions显示文摘 | Ferguson T A Mahendra A L Hooper P | 1992 | Invest Opththal Vis Sci1992，33，： | 1 |
| 7 | Diffusing capacity predicts morbidity and mortality after pulmonary resection显示文摘 | Ferguson MK Little L Rizzo L | 1988 | Thorac Cardiovasc Surg1988，96，6： | 1 |
| 8 | The Berlin definition of ARDS: an expanded rationale, justification, and supplementary material 显示文摘 | Ferguson ND Fan E Camporota L | 2012 | Intensive Care Med2012，38，10： | 1 |
| 9 | The Berlin definition of ARDS: an expanded rationa lejustification, and supplementary material显示文摘 | FERGUSON N D FAN E CAMPOROTA L | 2012 | Inten- sive Care Med2012，38，： | 1 |
| 10 | Immunogenic and tolerogenic cell death显示文摘 | Green D R Ferguson T Zitvogel L A | 2009 | Nat Rev Immunol2009，9，5： | 1 |
| 11 | Glutathione S -transferase P1 ( GSTP1 ) directly influences platinum drug chemosensitivity in ovarian tumour cell lines 显示文摘 | Sawers L Ferguson MJ Ihrig BR | 2014 | Br J Cancer2014，111，6： | 1 |
| 12 | Molecular cloning and characterization of prostase, an androgen-regulated serine protease with prostare-restricted expression 显示文摘 | Nelson P S Gan L Ferguson C | 1999 | Proc Natl Acad Sci USA1999，96，6： | 1 |
| 13 | Kinetic analysis of urea transport from plasma to milk in dairy cows显示文摘 | Baker L D Ferguson J D Ramber C F | 1992 | J Dairy Sci1992，75，： | 1 |
| 14 | Toll-Like Receptors and Cancer:MYD88 Mutation and Inflammation显示文摘 | WANG J Q JEELALL Y S FERGUSON L L | 2014 | Front Immunol2014，5，： | 1 |
| 15 | The concentrations of iron, calcium, zinc and phytate in cereals and legumes habitually consumed by infants linving in East Lombok, Indonesia显示文摘 | CHAN S L FERGUSON E L BAILEY K | 2007 | Journal of Food Composition and Analysis2007，20，7： | 1 |
| 16 | Glutathione S- transferase P1 (GSTP1) directly influences platinum drug ehemosensitivity in ovarian tumour cell lines显示文摘 | Sawers L Ferguson M J Ihrig BR | 2014 | Br J Cancer2014，111，6： | 1 |
| 17 | Nuclear Level Densities in Intermediate and Heavy Nuclei显示文摘 | COOK J L FERGUSON H MUSGROVE A R D | 1967 | Australian Journal of Physics1967，20，： | 1 |
| 18 | Coexistence of ankylosing spondylitis and rheumatoid arthritis显示文摘 | luthra H S Ferguson R H Conn D L | 2004 | Arthritis Rheum2004，19，： | 1 |
| 19 | Delayed effects of exercise on the plasma leptin concentration显示文摘 | ALDERSON N L FERGUSON M A | 2000 | Metabolism2000，49，3： | 1 |
| 20 | Osteoprotegerin mitigates tail suspension-induced osteopenia显示文摘 | Bateman T A Dunstan C R Ferguson V L et al | 2000 | Bone2000，，26： | 1 |
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