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| 1 | Towards precision medicine:advances in 5-hydroxymethylcytosine cancer biomarker discovery in liquid biopsy显示文摘Robust and clinically convenient biomarkers for cancer diagnosis,early detection,and prognosis have great potential to improve patient survival and are the key to precision medicine.The advent of next-generation sequencing technologies enables a more sensitive and comprehensive profiling of genetic and epigenetic information in tumor-derived materials.Researchers are now able to monitor the dynamics of tumorigenesis in new dimensions,such as using circulating cell-free DNA(cfDNA)and tumor DNA(ctDNA).Mutation-based assays in liquid biopsy cannot always provide consistent results across studies due partly to intra-and inter-tumoral heterogeneity as well as technical limitations.In contrast,epigenetic analysis of patient-derived cfDNA is a promising alternative,especially for early detection and disease surveillance,because epigenetic modifications are tissue-specific and reflect the dynamic process of cancer progression.Therefore,cfDNA-based epigenetic assays are emerging to be a highly sensitive,minimally invasive tool for cancer diagnosis and prognosis with great potential in future precise care of cancer patients.The major obstacle for applying epigenetic analysis of cfDNA,however,has been the lack of enabling techniques with high sensitivity and technical robustness.In this review,we summarized the advances in epigenome-wide profiling of 5-hydroxymethyl-cytosine(5hmC)in cfDNA,focusing on the detection approaches and potential role as biomarkers in different cancer types. | Chang Zeng Emily Kunce Stroup Zhou Zhang Brian C-HChiu Wei Zhang | 2019 | Cancer Communications2019，39，1： | 7 |
| 2 | 化学镀镍的发色工艺显示文摘有色化学镀镍镀层具有振奋人心的崭新市场。本文综述了化学镀镍层的发色方法,包括浸渍、电解与热氧化等,色彩有黑、蓝、绿、草绿、铜、灰等色。 | David Kunces 吴承东 | 1990 | 电镀与环保1990，10，1： | 2 |
| 3 | Numerical Determination of Carrying Capacity of Large Rolling Bearlngs显示文摘 | Kunc R Prebil I | 2004 | Journal of Materials Processing Technology2004，，155156： | 1 |
| 4 | Destructive inter jurisdictional competition:firm,capital,and labor mobility in a model of direct emission control显示文摘 | Kunce M Shogren J | 2007 | Ecological Economics2007，，60： | 1 |
| 5 | Low - cycle Fatigue Properties of Steel 42CrMo4 显示文摘 | Kunc R Prebil I | 2003 | Materials Science and Engineering2003，，345： | 1 |
| 6 | Strategic fn- resight fi)r (coastal) urban tourism market complexity: The case of Bournemouth显示文摘 | Sheena Carlisle Aleksander Johansen Martin Kunc | 2016 | Coastal Management2016，，54： | 1 |
| 7 | A model for fiber length attrition in injection-molded long-fiber composites 显示文摘 | Phelps J H Abd E1-Rahman A I Kunc V | 2013 | Com-posites Part A: Applied Science and Manufacturing2013，51，： | 1 |
| 8 | Experimental Determination of Damage to Bearing Raceways in Rolling Rotational Connections 显示文摘 | Zupan S Kunc R Prebil I | 2006 | Experimental Techniques2006，30，2： | 1 |
| 9 | Forecasting the development of wine tourism:a case study in Chile显示文摘 | Kunc MH | | 0，，04： | 1 |
| 10 | Coal powerplant flue gas waste heat and water recovery 显示文摘 | Dexin Wang Aman Bao Waiter kunc | 2011 | Applied Energy2011，91，1： | 1 |
| 11 | Numerical determination of carrying capacity of large rolling bearings 显示文摘 | Kunc R Prebil I | 2004 | Journal of Materials Processing Technology2004，，： | 1 |
| 12 | Numerical Determination of Carrying Capacity of Large Rolling Bearings 显示文摘 | Kunc R Prebil I | 2004 | Journal of Mate- rials Processing Technology2004，，155156： | 1 |
| 13 | Numerical Determina- tion of the Carrying Capacity of Rolling Rotational Con- nections 显示文摘 | Kunc R Zerovnik A Zvokelj M | 2007 | Materials and Technology2007，，2： | 1 |
| 14 | Spectrophotometric application of resazurin reduction assay to evaluate boar semen quality显示文摘 | Zrimsek P Kunc J Kosec M | 2004 | International Journal of Andrology2004，27，1： | 1 |
| 15 | A comparative studyon reactive and non-reactive unbalanced magnetronsputter deposition of TiN coatings显示文摘 | Mayrhofer P H Kunc F Musil J | 2002 | Thin solid films2002，415，1： | 1 |
| 16 | Experimental Determina- tion of Damage to Bearing Raceways in Rolling Rota- tional Connections 显示文摘 | Zupan S Kunc R Prebil I | 2006 | Experimental Techniques2006，30，2： | 1 |
| 17 | Numerical determination of the carrying capacity of rolling rotational connections显示文摘 | Robert Kunc Andrej Zerovnik Matej Zvokelj | 2007 | Materials and technology2007，，41： | 1 |
| 18 | High-pressure phases of lithia Li20:First-principles calculations 显示文摘 | Kunc K Loa I Syassen K | 2008 | Phys Rev B2008，77，94： | 1 |
| 19 | Destructive Inter-jurisdictional Competition : Firm, Capital and Labor Mobility in a Model of Direct Emission Control显示文摘 | Kunce M Shogren J F | 2007 | Ecological Economics2007，60，3： | 1 |
| 20 | Patterns of surface temperatures in two mole-rats(Bathyergidae)with different social systems as revealed by IR-thermography显示文摘 | Sumbera R Zelova J Kunc P | 2007 | Physiol Behav2007，92，3： | 1 |
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