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| 1 | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease显示文摘BACKGROUND:Regulatory peptide receptors have attracted the interest of oncologists as a new promising approach for cancer pathology,imaging and therapy.Although cholecystokinin (CCK) is a potent modulator of gallbladder contractility and plays a potential role in pancreatic carcinogenesis through CCK type-A receptor (CCKAR),its role in gallbladder cancer (GBC) is still unknown and immunohistochemical detection of CCKAR in the gallbladder has not yet been reported.This novel case-control study aimed to investigate the expression profile of CCKAR in GBC and gallstone disease (GSD).METHODS:This study included 162 samples of gallbladder:94 from GBC and 68 from GSD.Expression of CCKAR was analyzed by immunohistochemistry and immunoblotting.The results were statistically correlated with disease history including age,sex,presence of gallstone,stage and differentiation.RESULTS:CCKAR was positive in 30/68 (44.1%) of GSD and 72/94 (76.6%) of GBC samples.Fifty-one of the 72 (70.8%) CCKAR-positive GBC samples showed over-expression.Interestingly,consistent results also appeared in the immunoblotting study.CONCLUSIONS:CCKAR expression was significantly increased in GBC compared to GSD.Moreover,CCKAR expression was associated with the degree of tumor differentiation,i.e.,less expression in poorly-differentiated tumors.Thus,it has future prognostic and therapeutic implications in the management of GBC. | Rajani Rai Mallika Tewari Mohan Kumar Tej Bali Singh Hari S Shukla | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 2 | Characterization of microstructures in Inconel 625 using X-ray diffraction peak broad- ening and lattice parameter measurements显示文摘 | RAI S K KUMAR A SHANKAR V | 2004 | Scripta Materialia2004，51，1： | 1 |
| 3 | Magnetic resonance imaging in lung:A Review of its potential for Radiotherapy显示文摘 | Kumar S Liney G Rai R | 2016 | Br J Radiol2016，89，20： | 1 |
| 4 | Association of endotheli- al nitric oxide synthase gene polymorphisms with coronary artery disease:an updated meta-analysis and systematic review显示文摘 | RAI H PARVEEN F KUMAR S | 2014 | PLoS One2014，9，11： | 1 |
| 5 | Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long-term cerebral hypoperfusion显示文摘 | Rai S Kumar M | 2004 | Pharmacology Biochemistry and Behavior2004，79，： | 1 |
| 6 | Er3+/Yb3 + co- doped Gd203 nano - phosphor for optical thermometry 显示文摘 | SINGH S K KUMAR K RAI S B | 2009 | Sens Actuators A2009，149，： | 1 |
| 7 | Cord blood and breast milk iron status in maternal anemia显示文摘 | Kumar A Rai A K Basu S | 2008 | Pediatrics2008，121，3： | 1 |
| 8 | Central nervous system sites of the sleep promoting effects of eszopiclone in rats显示文摘 | Kumar S Alam MN Rai S | 2011 | Neuro- sciencs2011，181，： | 1 |
| 9 | Growth and characterization of ZnO nanostructured thin films by a two step chemical method 显示文摘 | Kumar P S Rai A D Mangalaraj D | 2008 | Applied Surface Science2008，255，： | 1 |
| 10 | Vibration- al spectrum of glycine molecule 显示文摘 | Kumar S Rai A K Singh V B etal | 2005 | Speetro- chimica Acta Part A2005，61，： | 1 |
| 11 | Thyroid function in type 2 diabetes mellitus and in diabetic nephropathy显示文摘 | Rai S Kumar JA | 2013 | J Clin Diagn Res2013，7，8： | 1 |
| 12 | Computing terminal reliability of computer network 显示文摘 | Rai S Kumar A Prasad E V | 1986 | Reliability Engineering1986，16，2： | 1 |
| 13 | Temperature dist- ribution and residual stresses due to muhipass welding in type 304 stainless steel and low carbon steel weld pads显示文摘 | Murugan S Rai S K Kumar P V | 2001 | International Journal of Pressure Vessels and Piping2001，78，4： | 1 |
| 14 | β-endorphin inhibits phagocytic activity of lizard splenic phagocytes through μ-receptor-coupled adenylate cyclase-protein kinase A signaling pathway显示文摘 | Kumar S Ghorai SM Rai U | | 0，，： | 1 |
| 15 | Statistical optimi- zation of Bacillus alcalophilus A-amylase immobilization on iron-oxide magnetic nanoparticles显示文摘 | Mukherjee A K Kumar T S Rai S K | 2010 | Biotechnol Bio- pro E2010，15，6： | 1 |
| 16 | Isotopic characteristics of Indian precipitation显示文摘 | Kumar B Rai S P Kumar U S | 2010 | Water Resources Research2010，46，12： | 1 |
| 17 | Statistical optimization of Bacillus alcalophilus a-amylase immobilization on iron-oxide magnetic nanoparticles显示文摘 | Mukherjee A K Kumar T S Rai J K | | 0，，06： | 1 |
| 18 | On Computer Communication Network Reliability Under Program Execution Constraints显示文摘 | KUMAR A RAI S AGRAWAL DP | 1988 | IEEE Jounal on Selected Area in Communications1988，6，8： | 1 |
| 19 | A1 receptor me- diated adenosinergic regulation of perifornical-later- al hypothalamic area neurons in freely behaving rats 显示文摘 | Rai S Kumar S Alam MA | 2010 | Neuroscience2010，167，1： | 1 |
| 20 | Thyroid function in type 2 diabetes mellitus and in diabetic nephropathy 显示文摘 | Rai S Kumar J A K P | 2013 | J Clin Diagn Res2013，7，8： | 1 |
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