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| 1 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 2 | Comparison of PCR,culture&serological tests for the diagnosis of Mycoplasma pneumonia in community-acquired lower respiratory tract infection in children显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | India J Med Res2008，128，2： | 1 |
| 3 | Spontaneous intmcystic hemorrhage of the arachnoid cyst: a case report and review of literature显示文摘 | Jha R Sharma GR Kumar P | 2008 | JNMA J Nepal Med Assoc2008，47，172： | 1 |
| 4 | Comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae in community-acquired lower respiratory tract infections in children显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | Indian J Med Res2008，128，2： | 1 |
| 5 | comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae in community-acquired lower respitory tract infections in children 显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | India J Med Res2008，128，2： | 1 |
| 6 | Targeting the minor groove of DNA: crystal structures of two complexes be- tween furan derivatives of berenil and the DNA dodecam- er d (CGCGAATTCGCG) 2显示文摘 | Trent JO Clark GR Kumar A | 1996 | J Med Chem1996，39，23： | 1 |
| 7 | Comparison of PCR, culture & serological tests for the diagnosis of mycoplasma pneumoniae in community-acquired lower respitory tract infections in children显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | India J Med Res2008，128，2： | 1 |
| 8 | Crouzon's Syndrome: A Case Report显示文摘 | Kumar GR Jyothsna M Ahmed SB | 2013 | Int J Clin Pediatr Dent2013，6，1： | 1 |
| 9 | Unsymmetrical alkoxy zinc phthalocyanine for sensitization of nanocrystalline TiO 2 films显示文摘 | L. Giribabu Ch. Vijay Kumar V. Gopal Reddy P. Yella Reddy Ch. Srinivasa Rao Song-Rim Jang Jun-Ho Yum Md. K. Nazeeruddin M. Gr?tzel | 2007 | Solar Energy Materials and Solar Cells2007，，17： | 1 |
| 10 | Comparison of PCR, culture & serological tests for the diagnosis of mycoplasma pneumoniae in com- munity-acquired |ower respiratory tract infections in children 显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | Indian J Med Res2008，128，2： | 1 |
| 11 | Detection of mycoplas- ma pneumoniae in children with lower respiratory tract infections显示文摘 | Maheshwari M Kumar S Sethi GR | 2011 | Trop Doct2011，41，1： | 1 |
| 12 | Comparison ofPCR,culture&serological tests for the diagnosis of Mycoplasma pneumoniae in community-acquired lowerrespiratory tract infections in children显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | Indian J MedRes2008，128，2： | 1 |
| 13 | Solid Pseudopapillary Neoplasms of the Pancreas: A Multi-Institutional Study of 21 Patients显示文摘 | Jesus M. Matos Robert Grützmann Narasimhan P. Agaram Hans-Detlev Saeger Hari R. Kumar Keith D. Lillemoe C. Max Schmidt | 2009 | Journal of Surgical Research2009，，1： | 1 |
| 14 | Nipple involvement in peripheral breast carcinoma: a prospective study显示文摘 | Verma GR Kumar A Joshi K | 1997 | Indian J Cancer1997，34，1： | 1 |
| 15 | Applications of ICA and fractal dimension in sEMG signal processing for subtle movement analysis:a review显示文摘 | Naik GR Arjunan S Kumar D | 2011 | Australasian Physical & Engineering Sciences in Medicine2011，34，2： | 1 |
| 16 | Evaluation of narrow- band UVB phototherapy in 150 patients with vitiligo 显示文摘 | Kishan Kumar YH Rao GR Gopal KV | 2009 | Indian J Dermatol Venereol Leprol2009，75，2： | 1 |
| 17 | Nipple involvement in peripheral breast carcinoma:a prospective study显示文摘 | Verma GR Kumar A Joshi K | 1997 | Indian J Cancer1997，34，1： | 1 |
| 18 | Comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae in community-acquired lower respiratory tract infections in children 显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | Indian J Med Res2008，128，： | 1 |
| 19 | Evaluation of determination of 6-aminopenicillanic acid by p-dimethyl aminobenzaldehyde 显示文摘 | Shewale JG Kumar KK Ambekar GR | 1987 | Biotechnol Tech1987，1，1： | 1 |
| 20 | Comparison of PCR, culture & serological tests for the diagnosis of Mycoplasma pneumoniae in community -acquired lower respiratory tract infections in children 显示文摘 | Kashyap B Kumar S Sethi GR | 2008 | Indian J Med Res2008，128，2： | 1 |
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