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| 1 | Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis,oxidative damage and apoptosis in rats显示文摘AIM:To investigate the effects of bombesin (BBS) and neurotensin (NTS) on apoptosis and colitis in an ulcerative colitis model. METHODS:In this study, a total of 50 rats were divided equally into 5 groups. In the control group, no colitis induction or drug administration was performed. Colitis was induced in all other groups. Following the induction of colitis, BBS, NTS or both were applied to three groups of rats. The remaining group (colitis group) received no treatment. On the 11th d after induction of colitis and drug treatment, blood samples were collected for TNF-α and IL-6 level studies. Malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO) and caspase-3 activities, as well as histopathological findings, evaluated in colonic tissues. RESULTS:According to the macroscopic and microscopic findings, the study groups treated with BBS, NTS and BBS + NTS showed significantly lower damage and inflammation compared with the colitis group (macroscopic score, 2.1 ± 0.87, 3.7 ± 0.94 and 2.1 ± 0.87 vs 7.3 ± 0.94;microscopic score, 2.0 ± 0.66, 3.3 ± 0.82 and 1.8 ± 0.63 vs 5.2 ± 0.78, P < 0.01). TNF-α and IL-6 levels were increased significantly in all groups compared with the control group. These increases were significantly smaller in the BBS, NTS and BBS + NTS groups compared with the colitis group (TNF-α levels, 169.69 ± 53.56, 245.86 ± 64.85 and 175.54 ± 42.19 vs 556.44 ± 49.82;IL-6 levels, 443.30 ± 53.99, 612.80 ± 70.39 and 396.80 ± 78.43 vs 1505.90 ± 222.23, P < 0.05). The colonic MPO and MDA levels were significantly lower in control, BBS, NTS and BBS + NTS groups than in the colitis group (MPO levels, 24.36 ± 8.10, 40.51 ± 8.67 and 25.83 ± 6.43 vs 161.47 ± 38.24;MDA levels, 4.70 ± 1.41, 6.55 ± 1.12 and 4.51 ± 0.54 vs 15.60 ± 1.88, P < 0.05). Carbonyl content and caspase-3 levels were higher in the colitis and NTS groups than in control, BBS and BBS + NTS groups (carbonyl levels, 553.99 ± 59.58 and 336.26 ± 35.72 vs 209.76 ± 30.92, 219.76 ± 25.77 and 220.34 ± 36.95;caspase-3 levels, 451.70 ± 68.27 and 216.20 ± 28.17 vs 28.60 ± 6.46, 170.50 ± 32.37 and 166.50 ± 30.95, P < 0.05). CONCLUSION:The results of this study suggest BBS and NTS, through their anti-inflammatory actions, support the maintenance of colonic integrity and merit consideration as potential agents for ameliorating colonic inflammation. | Alper Akcan Sebahattin Muhtaroglu Hulya Akgun Hizir Akyildiz Can Kucuk Erdogan Sozuer Alper Yurci Namik Yilmaz | 2008 | World Journal of Gastroenterology2008，14，8： | 14 |
| 2 | Folic acid supplementation inhibits recurrence of colorectal adenomas:A randomized chemoprevention trial显示文摘AIM: To determine whether folic acid supplementation will reduce the recurrence of colorectal adenomas, the precursors of colorectal cancer, we performed a double-blind placebo-controlled trial in patients with adenomatous polyps. METHODS: In the current double-blind, placebo-controlled trial at this VA Medical Center, patients with colorectal adenomas were randomly assigned to receive either a daily 5 mg dose of folic acid or a matched identical placebo for 3 years. All polyps were removed at baseline colonoscopy and each patient had a follow up colonoscopy at 3 years. The primary endpoint was a reduction in the number of recurrent adenomas at 3 years. RESULTS: Of 137 subjects, who were eligible after confirmation of polyp histology and run-in period to conform compliance, 94 completed the study; 49 in folic acid group and 45 in placebo group. Recurrence of adenomas at 3-year was compared between the two groups. The mean number of recurrent polyps at 3-year was 0.36 (SD, 0.69) for folic acid treated patients compared to 0.82 (SD, 1.17) for placebo treated subjects, resulting in a 3-fold increase in polyp recurrence in the placebo group. Patients below 70 years of age and those with left-sided colonicadenomas or advanced adenomas responded better to folic acid supplementation. CONCLUSION: High dose folic acid supplementation is associated with a signif icant reduction in the recurrence of colonic adenomas suggesting that folic acid may be an effective chemopreventive agent for colorectal neoplasia. | Richard Jaszewski Sabeena Misra Martin Tobi Nadeem Ullah Jo Ann Naumoff Omer Kucuk Edi Levi Bradley N Axelrod Bhaumik B Patel Adhip PN Majumdar | 2008 | World Journal of Gastroenterology2008，14，28： | 10 |
| 3 | Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats显示文摘AIM: To investigate the effects of exogenous melatonin on bacterial translocation and apoptosis in a rat ulcerati-ve colitis model. METHODS: Rats were randomly assigned to three groups: groupⅠ: control, group Ⅱ: experimental colitis, group Ⅲ: colitis plus melatonin treatment. On d 11 after colitis, plasma tumor necrosis factor-α, portal blood endotoxin levels, colon tissue myeloperoxidase and caspase-3 activity were measured. Bacterial translocation was quantified by blood, lymph node, liver and spleen culture. RESULTS: We observed a significantly reduced inciden-ce of bacterial translocation to the liver, spleen, mesen-teric lymph nodes, portal and systemic blood in animals treated with melatonin. Treatment with melatonin signifi-cantly decreased the caspase-3 activity in colonic tissues compared to that in trinitrobenzene sulphonic acid-trea-ted rats (16.11 ± 2.46 vs 32.97 ± 3.91, P < 0.01). CONCLUSION: Melatonin has a protective effect on ba-cterial translocation and apoptosis. | Alper Akcan Can Kucuk Erdogan Sozuer Duygu Esel Hizir Akyildiz Hulya Akgun Sabahattin Muhtaroglu Yucel Aritas | 2008 | World Journal of Gastroenterology2008，14，6： | 5 |
| 4 | Neutrophil-to-lymphocyte ratio in occlusive vascular diseases: the literature review of the past 10 years显示文摘BACKGROUND: This study aims to evaluate the results of studies investigating neutrophilto-lymphocyte ratio(NLR) and to identify the prognostic and diagnostic value of NLR in occlusive vascular diseases.METHODS: With the aim of identifying the studies related to NLR, a search was performed on http://gffzz16a62c593b5540cehof5xkqob6vuw6bo6.ffgz.tsg.suse.edu.cn/pubmed by using the key words 'neutrophil lymphocyte ratio' between January 2005 and December 2014. All of the original articles were evaluated according to date of publications, countries, clinics and topics. Studies about occlusive vascular diseases were evaluated according to their qualifications, review methods and results. SPSS for Windows 16.0 was used in data analysis and data were expressed as mean, standard deviation and percentage.RESULTS: A total of 735 original research articles were investigated. The number of publications have shown a regular logarithmic increase over the years. Thirty-two percent of all publications were performed by clinics in Turkey and 56.4% were performed by general-oncological surgery and cardiology clinics. A total of 107 publications were identified to be about occlusive vascular diseases, 80.3% of these publications were found to be prognostic and 19.6% to be diagnostic, 82.2% of them were found to be planned as retrospective and 17.7% as prospective. In 95.3% of prognostic publications, there was a positive correlation between high NLR values at admission and poor prognosis. In 95.3% of diagnostic publications high NLR values at admission were identifi ed to be signifi cant diagnostically.CONCLUSION: Elevated neutrophil-to-lymphocyte ratio at admission, could be used as a diagnostic and/or prognostic parameter in occlusive vascular diseases. | Egemen Kucuk Ibrahim Kocayigit Candan Gunel Hasan Duzenli | 2016 | World Journal of Emergency Medicine2016，7，3： | 4 |
| 5 | Sirtuins as novel players in the pathogenesis of diabetes mellitus显示文摘Diabetes mellitus(DM) is a systemic and complex disease with micro and macrovascular complications that result from impaired metabolic pathways and genetic susceptibilities. DM has been accepted as an epidemic worldwide during the last two decades. A substantial gap in our knowledge exists regarding the pathophysiology of this metabolic disorder despite the improved diagnostic tools and therapeutic approaches. Sirtuins are a group of NAD+ dependent enzymes that are involved in cellular homeostasis due to their deacetylating activity. In the present review, we aimed to discuss the role of associated sirtuins in the pathogenesis and treatment of diabetes mellitus. | Kultigin Turkmen Ali Karagoz Adem Kucuk | 2014 | World Journal of Diabetes2014，5，6： | 3 |
| 6 | Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats显示文摘象 Glucagon 一样 peptide-2 (GLP-2 ) 有有势力反煽动性完成并且免于试验性的 ischemia/reperfusion (I/R ) 在肺、肠、心肌的织物的损害。然而,它对在肝的 I/R 损害的保护的能力是未知的。我们在老鼠在肝的 I/R 损害上调查了 GLP-2 预告的处理的潜在的角色。24 只老鼠的一个总数随机被划分成三个组(n = 8 ) 。第一个组是控制组;第二个组是对待车辆的肝的 ischemia/reperfusion (HIR,车辆盐对待) 组;并且第三个组是 GLP-2 pretreated I/R (GLP2 红外) 组。在第三个组的每只老鼠 intraperitoneally 被管理 5 ????? ???? 溜吗?? | Naci Topaloglu Adem Kucuk Sule Yildirm Mustafa Tekin Havva Erdem Mustafa Deniz | 2015 | Frontiers of Medicine2015，9，3： | 2 |
| 7 | A novel preoperative inflammatory marker prognostic score in patients with localized and metastatic renal cell carcinoma显示文摘Objective:Several inflammatory markers have been studied as potential biomarkers in renal cell carcinoma(RCC),however few reports have analyzed their prognostic value in aggregate and in non-clear cell histologies.We hypothesize that a combination of specific inflammatory markers into an RCC Inflammatory Score(RISK)could serve as a rigorous prognostic indicator of overall survival(OS)in patients with clear cell and non-clear cell RCC.Methods:Combination of preoperative C-reactive protein(CRP),albumin,erythrocyte sedimentation rate(ESR),corrected calcium,and aspartate transaminase to alanine transaminase(AST/ALT)ratio was used to develop RISK.RISK was developed using grid-search methodology,receiver-operating-characteristic(ROC)analysis,and sensitivity-specificity trade-off analysis.Prognostic value of RISK was analyzed using the KaplaneMeier method and Cox proportional regression models.Predictive accuracy was compared with RISK to Size,Size,Grade,and Necrosis(SSIGN)score,University of California-LOS Angeles(UCLA)Integrated Staging System(UISS),and Leibovich Prognosis Score(LPS). | Rishi R.Sekar Dattatraya Patil Yoram Baum Jeffrey Pearl Anna Bausum Mehmet A.Bilen Omer Kucuk Wayne B.Harris Bradley C.Carthon Mehrdad Alemozaffar Christopher P.Filson John G.Pattaras Peter T.Nieh Kenneth Ogan Viraj A.Master | 2017 | Asian Journal of Urology2017，4，4： | 2 |
| 8 | Responses of quail to dietary Vitamin E and zinc picolinate at different environmental temperatures显示文摘 | K. Sahin M. Onderci N. Sahin F. Gulcu N. Y?ld?z M. Avc? O. Kucuk | 2005 | Animal Feed Science and Technology2005，，1： | 2 |
| 9 | Determinationoftram- adolhydrochlorideinampouledosageformsby using UV spectrophotometric and HPLC-DADrnethods inmethanolandwatermedia显示文摘 | KUCUK A KADYOCGCLU Y | 2005 | I1 Farmaco2005，60，： | 1 |
| 10 | Zinc supplementation alleviates heat stress in laying Japanese quail显示文摘 | SAHIN K KUCUK O | 2003 | Journal of Nutrition2003，33，： | 1 |
| 11 | A clinical dilemma:cardiac and pericardiac echinococcosis显示文摘 | Birincioglu CL Bardakci H Kucuker SA | 1999 | Ann Thorac Surg1999，68，： | 1 |
| 12 | Treatment for microcarcinoma of the thyroid -clinical experience显示文摘 | Kucuk NO Tari P Tokmak E | 2007 | Clin Nucl Med2007，32，4： | 1 |
| 13 | Effects of tree species and topography on soil chemistry, litter quality, and decomposition in Northeast Turkey显示文摘 | Sariyildiz T Anderson J M Kucuk M | 2005 | Soil Biology & Biochemistry2005，37，： | 1 |
| 14 | Effects of quercetin on apoptosis,NF-κB and NOS gene expression in renal ischemia/reperfusion injury显示文摘 | Kinaci MK Erkasap N Kucuk A | 2012 | Exp Ther Med2012，3，2： | 1 |
| 15 | Phase II trial of bicalutamide in patients with advanced prostate cancer in whom conventional hormonal therapy failed:a Southwest Oncolo- gy Group study (SWOG 9235) 显示文摘 | KUCUK O FISHER E MOINPOUR CM | 2001 | Urology2001，58，1： | 1 |
| 16 | Effects of chromium and ascorbic acid supplementation on growth, carcass traits, serum metabolites, and antioxidant statu; of broiler chickens reared at a high ambient temperature (32℃) 显示文摘 | Sahin K Sahin B Kucuk O | 2003 | Nutrition Research2003，23，： | 1 |
| 17 | New model for single layer drying显示文摘 | Midilli A Kucuk H Yapar Z A | 2002 | Drying Technology2002，20，7： | 1 |
| 18 | Evaluation of microhardness and elastic modulus of thermally sprayed nanostructured zirconia coatings 显示文摘 | Lima R S Kucuk A Berndt C C | 2001 | Surface and Coatings Technology2001，135，2： | 1 |
| 19 | Increased activity of lymph node cells in thermal injury显示文摘 | Kataranovski M Kucuk J Lilic D | 1992 | Reg Immunol1992，4，4： | 1 |
| 20 | Integrity of nanostructured partially stabilized zirconia after plasma spray processing显示文摘 | Lima R S Kucuk A Berndt C C | 2001 | Materials Science and Engineering A2001，313，： | 1 |
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