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1篇 您的检索式：作者名="Krochmal L."

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		题名	作者	年代	出处	被引量
	1	比较克林霉素/维A酸凝胶联用与每种药物单用和使用赋型剂治疗寻常型痤疮:由2219例受试者参与的两项随机、双盲、对照试验显示文摘Background: The development of a hydrogel to stabilize and solubilize clindamycin and tretinoin provides a single, oncedaily treatment for acne vulgaris. Objective: Our aim was to compare the efficacy and safety of the combination of clindamycin (1% ) and tretinoin (0.025% ) with each agent alone and vehicle. Methods: Two randomized, double-blind, active drug-and vehicle-controlled 12-week studies evaluated inflammatory and noninflammatory lesion counts and the Investigator s Static Global Assessment in 2219 subjects with acne vulgaris. Results: The combination demonstrated superior efficacy to clindamycin, tretinoin, and vehicle. Combination hydrogel was significantly more effective in reducing inflammatory (P< .005), noninflammatory (P≤ .0004), and total (P< .0001) lesion counts than the other treatments and vehicle. The proportion of subjects with clear or almost clear skin on the Investigator s Static Global Assessment was greater with the combination (P< .0001). Limitations: A majority of subjects (82.6% ) had grade 2-3 acne vulgaris at baseline; therefore these overall results may not be representative of the response in the subjects (17.4% ) with grade 4- 5 acne. Conclusion: The combination clindamycin/tretinoin hydrogel was well tolerated and significantly more effective than clindamycin, tretinoin, or vehicle for the treatment of acne vulgaris.	Leyden J.J. Krochmal L. Yaroshinsky A. 李晓莉	2006	世界核心医学期刊文摘(皮肤病学分册)2006，0，4：	0

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