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您的检索式：作者名="Krist V.Gernaey"
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| 1 | A Mathematical Model for Simultaneous Saccharification and Co-fermentation (SSCF) of C6 and C5 Sugars显示文摘biofuels 并且明确地的可靠生产 bioethanol 最近吸引了研究的重要数量。在这上下文以内,这研究在为描述 C6 和 C5 糖的同时的 saccharification 和合作发酵(SSCF ) 开发一个数学模型处理 bioethanol 生产过程和特别地目的动态模拟。模型被为酶的水解作用和合作发酵联合存在数学模型构造。纤维素变换上的乙醇的抑制被介绍以便增加可靠性。为 SSCF 的数学模型被把模型预言与试验性的数据基于牛皮纸造纸厂污泥从乙醇生产获得了作比较验证。当适合模型到数据时,为葡萄糖和木糖新陈代谢的仅仅收益系数被调整,它被发现是 0.43 g ??? ‵????? 匠捡档牡晩捩瑡潩 ??????? 卓 ????? | Ricardo Morales-Rodriguez Krist V.Gernaey Anne S.Meyer Gürkan Sin | 2011 | Chinese Journal of Chemical Engineering2011，19，2： | 1 |
| 2 | Synergistic optimization framework for the process synthesis and design of biorefineries显示文摘The conceptual process design of novel bioprocesses in biorefinery setups is an important task,which remains yet challenging due to several limitations.We propose a novel framework incorporating superstructure optimization and simulation-based optimization synergistically.In this context,several approaches for superstructure optimization based on different surrogate models can be deployed.By means of a case study,the framework is introduced and validated,and the different superstructure optimization approaches are benchmarked.The results indicate that even though surrogate-based optimization approaches alleviate the underlying computational issues,there remains a potential issue regarding their validation.The development of appropriate surrogate models,comprising the selection of surrogate type,sampling type,and size for training and cross-validation sets,are essential factors.Regarding this aspect,satisfactory validation metrics do not ensure a successful outcome from its embedded use in an optimization problem.Furthermore,the framework’s synergistic effects by sequentially performing superstructure optimization to determine candidate process topologies and simulationbased optimization to consolidate the process design under uncertainty offer an alternative and promising approach.These findings invite for a critical assessment of surrogatebased optimization approaches and point out the necessity of benchmarking to ensure consistency and quality of optimized solutions. | Nikolaus IVollmer Resul Al Krist V.Gernaey Gürkan Sin | 2022 | Frontiers of Chemical Science and Engineering2022，16，2： | 1 |
| 3 | Digital Twin in biomanufacturing:challenges and opportunities towards its implementation显示文摘The domain of industrial biomanufacturing is enthusiastically embracing the concept of Digital Twin,owing to its promises of increased process efficiency and resource utilisation.However,Digital Twin in biomanufacturing is not yet clearly defined and this sector of the industry is falling behind the others in terms of its implementation.On the other hand,some of the benefits of Digital Twin seem to overlap with the more established practices of process control and optimization,and the term is vaguely used in different scenarios.In an attempt to clarify this issue,we investigate this overlap for the specific case of fermentation operation,a central step in many biomanufacturing processes.Based on this investigation,a framework built upon a five-step pathway starting from a basic steady-state process model is proposed to develop a fully-fledged Digital Twin.For demonstration purposes,the framework is applied to a bench-scale second-generation ethanol fermentation process as a case study.It is proposed that the success or failure of a fully-fledged Digital Twin implementation is determined by key factors that comprise the role of modelling,human operator actions,and other propositions of economic value. | Isuru A.Udugama Pau C.Lopez Carina L.Gargalo Xueliang Li Christoph Bayer Krist V.Gernaey | 2021 | Systems Microbiology and Biomanufacturing2021，1，3： | 1 |
| 4 | Evaluation of the energy efficiency of enzyme fermentation by mechanistic modeling显示文摘 | Mads O.Albaek Krist V.Gernaey Morten S.Hansen Stuart M.Stocks | 2012 | Biotechnol. Bioeng2012，，4： | 1 |
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