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1篇 您的检索式:作者名="Krishna C.R.Kolan"
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1Near-field electrospinning of a polymer/bioactive glass composite to fabricate 3D biomimetic structures显示文摘Bioactive glasses have recently gained attention in tissue engineering and three-dimensional(3D)bioprinting because of their ability to enhance angiogenesis.Some challenges for developing biological tissues with bioactive glasses include incorporation of glass particles and achieving a 3D architecture mimicking natural tissues.In this study,we investigate the fabrication of scaffolds with a polymer/bioactive glass composite using near-field electrospinning(NFES).An overall controlled 3D scaffold with pores,containing random fibers,is created and aimed to provide superior cell proliferation.Highly angiogenic borate bioactive glass(13-93B3)in 20 wt.%is added to polycaprolactone(PCL)to fabricate scaffolds using the NFES technique.Scaffolds measuring 5 mm×5 mm×0.2 mm^3 in overall dimensions were seeded with human adipose-derived mesenchymal stem cells to investigate the cell viability.The cell viability on PCL and PCL+glass scaffolds fabricated using NFES technique and 3D printing is compared and discussed.The results indicated higher cell proliferation on 3D biomimetic scaffolds fabricated by NFES technique.Krishna C.R.Kolan Jie Li Sonya Roberts Julie A.Semon Jonghyun Park Delbert E.Day Ming C.Leu 2019International Journal of Bioprinting2019,5,1:0
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