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| 1 | Primary and secondary organic aerosol in an urban/industrial site: Sources, health implications and the role of plastic enriched waste burning显示文摘PM_(1)0 samples were collected from an urban/industrial site nearby Athens,where uncontrolled burning activities occur.PAHs,monocarboxylic,dicarboxylic,hydroxycarboxylic and aromatic acids,tracers from BVOC oxidation,biomass burning tracers and bisphenol A were determined.PAH,monocarboxylic acids,biomass burning tracers and bisphenol A were increased during autumn/winter,while BSOA tracers,dicarboxylic-and hydroxycarboxylic acids during summer.Regarding aromatic acids,different sources and formation mechanisms were indicated as benzoic,phthalic and trimellitic acids were peaked during summer whereas p-toluic,isophthalic and terephthalic were more abundant during autumn/winter.The Benzo[a]pyrene-equivalent carcinogenic power,carcinogenic and mutagenic activities were calculated showing significant(p<0.05)increases during the colder months.Palmitic,succinic and malic acids were the most abundant monocarboxylic,dicarboxylic and hydrocarboxylic acids during the entire sampling period.Isoprene oxidation was the most significant contributor to BSOA as the isoprene-SOA compounds were two times more abundant than the pinene-SOA(13.4±12.3 and 6.1±2.9 ng/m^3,respectively).Ozone has significant impact on the formation of many studied compounds showing significant correlations with:isoprene-SOA(r=0.77),hydrocarboxylic acids(r=0.69),pinene-SOA(r=0.63),dicarboxylic acids(r=0.58),and the sum of phthalic,benzoic and trimellitic acids(r=0.44).PCA demonstrated five factors that could explain sources including plastic enriched waste burning(30.8%),oxidation of unsaturated fatty acids(23.0%),vehicle missions and cooking(9.2%),biomass burning(7.7%)and oxidation of VOCs(5.8%).The results highlight the significant contribution of plastic waste uncontrolled burning to the overall air quality degradation. | Panagiotis Georgios Kanellopoulos Eleni Verouti Eirini Chrysochou Konstantinos Koukoulakis Evangelos Bakeas | 2021 | Journal of Environmental Sciences2021，33，1： | 4 |
| 2 | The role of mycophenolate in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis显示文摘Mycophenolic acid, the active metabolite for mycophenolate mofetil and mycophenolic sodium, is a strong, noncompetitive, reversible inhibitor of inosine monophosphate dehydrogenase, the key enzyme in de novo synthesis of guanosine nucleotides leading to selective inhibition of lymphocyte proliferation. Mycophenolic acid has been evaluated as induction and remission maintenance agent in the treatment of antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Since the course of disease of AAV usually requires long term immunosuppression, mycophenolate has been explored as a less toxic agent compared to cyclophosphamide and azathioprine. Mycophenolate is a potent immunosuppressive agent in the therapy of AAV, non-inferior to other available drugs with comparable side effect profile. Therefore, it could be a valuable alternative in cases of toxicity with life threatening side effects or intolerance to cyclophosphamide or azathioprine, in cases with high cumulative dose of cyclophosphamide, but also in cases with insufficient response. Several studies have shown a higher relapse rate following discontinuation of mycophenolate or in mycophenolate treated subjects that raises concerns about its usefulness in the treatment of AAV. This review describes the efficacy of mycophenolate in AAV as remission induction agent, as remission maintenance agent, and as therapeutic option in relapsing AAV disease, the relapse rate following discontinuation of mycophenolate, and the adverse events related to mycophenolate treatment. | Maria Koukoulaki Christos Iatrou | 2019 | World Journal of Nephrology2019，8，4： | 2 |
| 3 | Successful endovascular treatment of transplant intrarenal artery stenosis in renal transplant recipients: Two case reports显示文摘Transplant renal artery stenosis(TRAS) is a relatively rare complication after renal transplantation. The site of the surgical anastomosis is most commonly involved, but sites both proximal and distal to the anastomosis may occur, as well. Angioplasty is the gold standard for the treatment of the stenosis, especially for intrarenal lesions. We report two cases of intrarenal TRAS and successful management with angioplasty without stent placement. Both patients were male, 44 and 55 years old respectively, and they presented with elevated blood pressure or serum creatinine within three months after transplantation. Subsequently, they have undergone angioplasty balloon dilatation with normalization of blood pressure and serum creatinine returning to baseline level. Percutaneous transluminal balloon renal angioplasty is a safe and effective method for the treatment of the intrarenal TRAS. | Maria Koukoulaki Elias Brountzos Ioannis Loukopoulos Maria Pomoni Eleni Antypa Vasileios Vougas Spiros Drakopoulos | 2015 | World Journal of Transplantation2015，5，2： | 2 |
| 4 | Mycophenolate rnofetil in anti -neu- trophil cytoplasm antobodies - associated systemic vasculitis 显示文摘 | Koukoulaki M Jayne DR | 2006 | Nephron Clin Pract2006，102，34： | 1 |
| 5 | Increased prevalence and severity of coronary artery calcification in patients with chronic kidney disease stage III and IV 显示文摘 | Koukoulaki M Papachfistou E Kalogeropoulou C | 2012 | Nephron Extra2012，2，1： | 1 |
| 6 | The accumulated experience with the use of mycophenolate mofetil in primary glomerulonephritis显示文摘 | Koukoulaki M Goumenos DS | 2010 | Expert Opin Investig Drug2010，19，5： | 1 |
| 7 | Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification显示文摘 | Lyons PA Koukoulaki M Hatton A | 2007 | BMC Genomics2007，8，： | 1 |
| 8 | Plant nutrition aspects under treated wastewater reuse management显示文摘 | Kalavrouziotis I K Koukoulakis P H | 2011 | Water Air and Soil PoUu- tion2011，218，14： | 1 |
| 9 | Mycophenolate mofetil in anti - neutrophil cytoplasm antibodies - associated systemic vasculitis 显示文摘 | Koukoulaki M Jayne DR | 2006 | Nephron Clin Pract2006，102，34： | 1 |
| 10 | Immunologic prognostic factors of renal allograft survival 显示文摘 | Koukoulaki M Kitsiou V Balaska A | 2014 | Transplant Proc2014，46，9： | 1 |
| 11 | Mycophenolate mofetil in anti-neutrophil cytoplasm antibodies-associated systemic vasculitis显示文摘 | Koukoulaki M Jayne DR | 2006 | Nephron Clin Pract2006，102，34： | 1 |
| 12 | The risks associated with wastewater reuse and xenobiotics in the agroecological environment显示文摘 | FATTA-KASSINOS D KALAVROUZIOTIS I K KOUKOULAKIS P H | 2011 | Science of the Total Environment2011，409，19： | 1 |
| 13 | Clinical experience with Gunther temporary inferior vena cava filters显示文摘 | Kaskarelis I S Koukoulaki M Chlapoutaki C E | 2006 | Clin Imaging2006，30，2： | 1 |
| 14 | Microarray analysis of human leucocyte subsets: the advantages of positive selection and rapid purification显示文摘 | Lyons P A Koukoulaki M Hatton A | 2007 | BMC Genomics2007，，8： | 1 |
| 15 | The impact of lean production on mus- culoskeletal and psychosocial risks: An examination of sociotechnical trends over 20 years显示文摘 | Koukoulaki T | 2014 | Applied Er- gonomics2014，45，2： | 1 |
| 16 | Total parathyroidectomy without autotransplantation in dialysis patients and renal transplant recipients, long-term follow-up evaluation显示文摘 | Spiros Drakopoulos Maria Koukoulaki Theofanis Apostolou Dimitrios Pistolas Katerina Balaska Stylianos Gavriil Valsamakis Hadjiconstantinou | 2009 | The American Journal of Surgery2009，，2： | 1 |
| 17 | The risks associated with wastewater reuse and xenobiotics in the agroecological environment显示文摘 | Fatta-Kassinos D Kalavrouziotis I K Koukoulakis P H | 2011 | Science of The Total Environment2011，409，19： | 1 |
| 18 | Transplantation of pediatric kidneys to adult recipients: an analysis of 13 cases 显示文摘 | Drakopoulos S Koukoulaki M Vougas V | 2004 | Transplant Proc2004，36，： | 1 |
| 19 | The risks associated with wastewater reuse and xenobiotics in the agroecological environment显示文摘 | Fatta-Kassinos D Kalavrouziotis I K Koukoulakis P H | 2011 | Sci Total Environ2011，409，19： | 1 |
| 20 | Mycophenolate mofetil in anti - neutrophil cytoplasm antibodies- associated systemic vasculitis显示文摘 | Koukoulaki M Jayne DR | 2006 | Nephron Clin Pract2006，102，34： | 1 |
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