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| 1 | Thermogenic protein UCP1 and UCP3 expression in non- small cell lung cancer: relation with glycolysis and anaerobic metabolism显示文摘Uncoupling protein 1(UCP1)is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat production.Using immunohistochemistry,we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer(NSCLC)treated with surgery.Expression patterns were correlated with histopathological variables,prognosis,and the expression of enzymes/proteins related to cell metabolism.Bronchial epithelium did not express UCP1 or UCP3,while alveolar cells strongly expressed UCP1.In tumors,strong expression of UCP1 and UCP3 was recorded in43/98(43.8%)and 27/98(27.6%)cases,respectively.UCP1 was significantly associated with squamous cell histology(P=0.05),whilst UCP3 was more frequently overexpressed in large cell carcinomas(P=0.08),and was inversely related to necrosis(P=0.009).In linear regression analysis,UCP1 was directly related to markers of glycolysis[hexokinase(HXKII)and phosphofructokinase(PFK1)]and anaerobic glucose metabolism[pyruvate dehydrogenase kinase(PDK1)and lactate dehydrogenase(LDH5)].UCP3 was directly linked with a glucose transporter(GLUT2),monocarboxylate transporter(MCT2),glycolysis markers(PFK1 and aldolase),and with the phosphorylation of pyruvate dehydrogenase(p PDH).Kaplan-Meier survival analysis showed that UCP3 was significantly related to poor prognosis in squamous cell carcinomas(P=0.04).UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption,intensified glycolysis,and anaerobic glucose usage.Whether UCPs are targets for therapeutic interventions in lung cancer is a hypothesis that demands further investigation. | Alexandra Giatromanolaki Konstantina Balaska Dimitra Kalamida Christos Kakouratos Efthimios Sivridis Michael I. Koukourakis | 2017 | Cancer Biology & Medicine2017，14，4： | 8 |
| 2 | Dietary probiotic inclusion level modulates intestinal mucin composition and mucosal morphology in broilers显示文摘 | Tsirtsikos P Fegeros K Balaskas C | | 0，，8： | 1 |
| 3 | Quality of life in patients with uraemic xerosis and pruritus 显示文摘 | Szepietowski JC Balaskas E Taube KM | 2011 | Aeta Derm Venereol2011，91，3： | 1 |
| 4 | Histamin and Serotonin in Uremic Pruritus: Effect of Ondansetron in CAPD prurltic patients显示文摘 | Balaskas EV Elias V Joumois D | 1998 | Nephron1998，78，： | 1 |
| 5 | Survival and complications of 225 catheters used in continuous ambulatory peritoneal dialysis:One-center experience in Northern Greece显示文摘 | Balaskas EV Ikonomopoulos D Sioulis A | 1999 | Perit Dial Int:1999，192，： | 1 |
| 6 | Incorporation of ceramic nanocontainers into epoxy coatings for the corrosion protection of hot dip galvanized steel 显示文摘 | Kartsonakis I A Balaskas A C Koumoulos E P | 2012 | Corrosion Science2012，57，4： | 1 |
| 7 | The Water Birth Book显示文摘 | Janet Balaskas Cathy Meeus | 2004 | Thorsons2004，，： | 1 |
| 8 | Histamine and serotonin in uremic pruritus: effect of ondansetron in CAPD-pruritic patients 显示文摘 | Balaskas EV Bamihas GI Karamouzis M | 1998 | Nephron1998，78，4： | 1 |
| 9 | Influence of cerium molybdate containers on the corrosion performance of epoxy coated aluminium alloys 2024-T3显示文摘 | Kartsonakis I A Balaskas A C Kordas G C | 2011 | Corrosion Science2011，53，11： | 1 |
| 10 | Incorporation of ceramic nanocontainers into epoxy coatings for the corrosion protection of hot dip galvanized steel显示文摘 | KARTSONAKIS I A BALASKAS A C KOUMOULOS E P | 2012 | Corrosion Science2012，57，： | 1 |
| 11 | ORMO- SIL-epoxy coating with ceramic containers for corrosion protec- tion of magnesium alloys ZK10显示文摘 | Kartsonakis I A Balaskas A C Koumoulos E P | 2013 | Progress in Organic Coat ings2013，76，23： | 1 |
| 12 | Indocyanine green angiography findings in acute retinal necrosis syndrome 显示文摘 | Bissig A Balaskas K Vaudattx J D | 2011 | Klin Monbl Augenheilkd2011，228，4： | 1 |
| 13 | Management of lipid abnomalities in patients with CAPD显示文摘 | Balaskas EV Bamihas GI Tourkantonis A | 1997 | Perit Dial Int1997，17，： | 1 |
| 14 | Changes in health-related quality of life in Greek adult patients 1 year after successful renal transplantation显示文摘 | Balaska A Moustafel os P Gourgiotis S | | 0，，02： | 1 |
| 15 | Quality of life in patients with uraemic xerosis and pruritus 显示文摘 | Szepietowski J C Balaskas E Taube K | 2011 | Acta Derm Vencreol2011，23，1： | 1 |
| 16 | Soxl maintains the undifferentiated state of cortical neural progenitor ceils via the suppression of Proxl-mediated cell cycle exit and neurogenesis 显示文摘 | Elkouris M Balaskas N Poulou M | 2011 | Stem Cells2011，29，1： | 1 |
| 17 | Immunologic prognostic factors of renal allograft survival 显示文摘 | Koukoulaki M Kitsiou V Balaska A | 2014 | Transplant Proc2014，46，9： | 1 |
| 18 | Effects of a multi-species probiotic on biomarkers of competitive exclusion efficacy in broilers challenged with Salmonella enteritidis 显示文摘 | Mountzouris K C Balaskas C Xanthakos I | 2009 | Brit Poultry Sci2009，50，4： | 1 |
| 19 | Bcell activating factor levels in rheumatoid arthritis patients in response to treatment with biologics显示文摘 | Pyrpasopoulou A Balaska E Triantafyllou A | 2012 | J Interferon Cytokine Res2012，32，7： | 1 |
| 20 | Relationship of age and psychosocial factors with biological ratings in patients with end-stage renal disease undergoing dialysis显示文摘 | Iacovides A Fountoulakis KN Balaskas E | 2002 | Aging Clin Exp Res2002，14，5： | 1 |
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