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| 1 | Vildagliptin-insulin combination improves glycemic control in Asians with type 2 diabetes显示文摘AIM: To assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in Asian patients with type 2 diabetes mellitus(T2DM).METHODS: This was a post hoc analysis of a subgroup of Asian patients from a multicenter,randomized,double-blind,placebo-controlled,parallel-group study in T2DM patients inadequately controlled by stable insulin therapy,with or without metformin.A total of 173 patients were randomized 1:1 to receive treatment with vildagliptin 50 mg bid(n = 87) or placebo(n = 86) for 24 wk.Changes in HbA1c and fasting plasma glucose(FPG),from baseline to study endpoint,were analyzed using an analysis of covariance model.Change from baseline to endpoint in body weight was summarized by treatment.Safety and tolerability of vildagliptin was also evaluated.RESULTS: After 24 wk,the difference in adjusted mean change in HbA1c between vildagliptin and placebo was 0.82%(8.96 mmol/mol;P < 0.001) in Asian subgroup,0.85%(9.29 mmol/mol;P < 0.001) in patients also receiving metformin,and 0.73%(7.98 mmol/mol;P < 0.001) in patients without metformin,all in favor of vildagliptin.There was no significant difference in the change in FPG between treatments.Weight was stable in both treatment groups(+0.3 kg and-0.2 kg,for vildagliptin and placebo,respectively).Overall,vildagliptin was safe and well tolerated with similarly low incidences of hypoglycemia(8.0% vs 8.1%) and no severe hypoglycemic events were experienced in either group.CONCLUSION: In Asian patients inadequately controlled with insulin(with or without concomitant metformin),insulin-vildagliptin combination treatment significantly reduced HbA1c compared with placebo,without an increase in risk of hypoglycemia or weight gain. | Plamen Kozlovski James Foley Qing Shao Valentina Lukashevich Wolfgang Kothny | 2013 | World Journal of Diabetes2013，4，4： | 6 |
| 2 | Intravenous administration of insulin lispro versus regular insulin in patients with type 1 diabetes显示文摘 | Stiller R Kothny T Gudat U | 1999 | Diabetes1999，48，1： | 1 |
| 3 | Improved glycaemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus显示文摘 | W. Kothny J. Foley P. Kozlovski Q. Shao B. Gallwitz V. Lukashevich | 2012 | Diabetes Obes Metab2012，，3： | 1 |
| 4 | Effect of oral post-menopausal hormone repalacement on progression of atherosclerosis : a tandomized, controlled trial Arerioscler Throm显示文摘 | Angerer P Stork S Kothny W | 2001 | Vasc Biol2001，21，： | 1 |
| 5 | The three phase equilibrium of mercury in nature, trace elements in the environments显示文摘 | Kothny E L | 1973 | ACS1973，123，： | 1 |
| 6 | Impact of social support,cynical hostility and anger expression on progression of coronary atherosclerosis显示文摘 | ANGERER P SIEBERT U KOTHNY W | 2000 | Am J Cardiol2000，36，： | 1 |
| 7 | One - year safety, tolera- bility and efficacy of vildagliptin in patients with type 2 diabetes and moderate or severe renal impairment 显示文摘 | Kothny W Shao Q Groop P H | 2012 | Diabetes Obes Metab2012，14，11： | 1 |
| 8 | One-year safety, tolerability and efficacy of vildagliptin in patients with type 2 diabetes and moderate or severe renal impairment显示文摘 | Kothny W Shao Q Groop PH | 2012 | Diabetes Obes Metab2012，14，11： | 1 |
| 9 | Effect of dietary supplementation with omega-3 fatty acids on progression of atherosclerosis in carotid arteries显示文摘 | Angerer P Kothny W Stork S | 2002 | Cardiovasc Res2002，54，： | 1 |
| 10 | lndividualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add- on or lone therapy(INTERVAL): a 24 week, randomised, double-blind, placebo-controlled study显示文摘 | Strain WD Lukashevich V Kothny W | 2013 | Lancet2013，382，9890： | 1 |
| 11 | The effect of dietaryv-3 fatty acids on coronary atherosclerosis a randomized,double-blind ,placebo-controlled trial 显示文摘 | Von Schacky C Angerer P Kothny W | 1999 | Ann Intern Med1999，130，： | 1 |
| 12 | Improved glycemic control with vildagliptin added to insulin, with or without metformin, in patients with type 2 diabetes mellitus显示文摘 | Kothny W Foley J Kozlovski P | 2013 | Diabetes Obes Metab2013，15，3： | 1 |
| 13 | The effect of dietary omega - 3 fatty acids on coronary atherosclerosis 显示文摘 | VON SCHACKY C ANGERER P KOTHNY W | 1999 | Annals of Internal Medicine1999，130，7： | 1 |
| 14 | Impact of social support,cynical hostility and anger expression on progression of coronary atherosclerosis显示文摘 | Angerer P Siebert U Kothny W | 2000 | J Am Coll Cardiol2000，36，6： | 1 |
| 15 | Analysis of carbonaceous material in southern California atmospheric aerosol显示文摘 | APPEL B R HOFFER E M KOTHNY E L | 1976 | Environmental Science & Technology1976，10，4： | 1 |
| 16 | Clinical evidence and mechanistic basis for vildagliptin’s effect in combination with insulin显示文摘 | Anja Schweizer Bo Ahren Wolfgang Kothny James Foley | 2013 | Vascular Health and Risk Management (default)2013，，： | 1 |
| 17 | The effect of dietary omega- 3 fgatty acid on coronary atherosclerosis: a randomized double- blind placebo - controlled trial 显示文摘 | Von Schachy C Angerer P Kothny W | 1999 | Ann Intern Med1999，130，7： | 1 |
| 18 | Ultraviolet light induces apoptosis via direct activation of CD95 ( FAS/APO-1) independently from its natural ligand CD95L 显示文摘 | Aragane Y Kulms D Kothny G | 1998 | J Cell Biol1998，140，： | 1 |
| 19 | Efficacy and safety of vildagliptin in patients with type 2 diabetes mellitus inadequately controlled with dual combination of metformin and sulphonylurea显示文摘 | V. Lukashevich S. D. Prato M. Araga W. Kothny | 2014 | Diabetes Obes Metab2014，，5： | 1 |
| 20 | Individualised treatment targets for elderly patients with type 2 diabetes using vildagliptin add-on or lone therapy (INTERVAL): a 24-week, randomised, double-blind, placebo-controlled study显示文摘 | Strain WD Lukashevich V Kothny W | 2013 | Lancet2013，382，9890： | 1 |
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