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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | Biofilm three-dimensional architecture influences in situ pH distribution pattern on the human enamel surface显示文摘To investigate how the biofilm three-dimensional(3D) architecture influences in situ pH distribution patterns on the enamel surface. Biofilms were formed on human tooth enamel in the presence of 1% sucrose or 0.5% glucose plus 0.5% fructose. At specific time points, biofilms were exposed to a neutral pH buffer to mimic the buffering of saliva and subsequently pulsed with 1% glucose to induce re-acidification. Simultaneous 3D pH mapping and architecture of intact biofilms was performed using two-photon confocal microscopy. The enamel surface and mineral content characteristics were examined successively via optical profilometry and microradiography analyses. Sucrose-mediated biofilm formation created spatial heterogeneities manifested by complex networks of bacterial clusters(microcolonies). Acidic regions(pH<5.5) were found only in the interior of microcolonies,which impedes rapid neutralization(taking more than 120 min for neutralization). Glucose exposure rapidly re-created the acidic niches, indicating formation of diffusion barriers associated with microcolonies structure. Enamel demineralization(white spots),rougher surface, deeper lesion and more mineral loss appeared to be associated with the localization of these bacterial clusters at the biofilm-enamel interface. Similar 3D architecture was observed in plaque-biofilms formed in vivo in the presence of sucrose. The formation of complex 3D architectures creates spatially heterogeneous acidic microenvironments in close proximity of enamel surface, which might correlate with the localized pattern of the onset of carious lesions(white spot like) on teeth. | Jin Xiao Anderson T Hara Dongyeop Kim Domenick T Zero Hyun Koo Geelsu Hwang | 2017 | International Journal of Oral Science2017，9，2： | 4 |
| 3 | Antibacterial roperties,corrosion resistance and mechanical properties of Cu-modified SUS 304stainless steel显示文摘 | Hong I T Koo C H | 2005 | Materials Science and Engineering A2005，393，： | 1 |
| 4 | A study on the applicability of radiant cooling using ondol 显示文摘 | Koo S Y Kim Y Y Seok H T | 2000 | Korean Journal of Air-Conditioning and Refrigeration Engineering2000，12，2： | 1 |
| 5 | Cementless alumina-on-a- lumina total hip arthroplasty in patients younger than 50 years:a 5 year minimum follow-up study显示文摘 | HA Y C KOO K H JEONG S T | 2007 | J Arthroplasty2007，22，2： | 1 |
| 6 | Catalyst-free growth of single-crystal silicon and germanium nanowires 显示文摘 | Kim B S Koo T W Lee J H | 2009 | Nano Lett2009，9，2： | 1 |
| 7 | The destruction of hazardous organic water materials显示文摘 | Takahashi Y Wydeven T Koo C | 1991 | Adv Space Res1991，99，8： | 1 |
| 8 | HyPocholesterolemic effects of Chinese tea显示文摘 | Yang T T Koo M W | 1997 | Pharmacol Res1997，35，6： | 1 |
| 9 | Cost-effectiveness and efficiency of shockwave lithotripsy vs flexible ureteroscopic holrnium:yttrium-alumiu- lure-garnet laser lithotripsy in the treatment of lower pole renal calculi 显示文摘 | Koo V Young M Thompson T | 2011 | B J U Int2011，108，： | 1 |
| 10 | De- velopment of a sustainability assessment model for under- ground infrastructure projects显示文摘 | KOO D H ARIARATNAM S T KAVAZANJIAN E | 2009 | Canadian Journal of Civil Engineering2009，36，5： | 1 |
| 11 | Contact stress transients during functional loading of ankle stepoff incongruities 显示文摘 | McKinley T O Rudert M J Koos D C | 2006 | J Biomech2006，39，4： | 1 |
| 12 | A collaborative event detec-tion scheme using fuzzy logic in clustered wireless sen-sor networks显示文摘 | KIEU-XUAN T KOO I | 2011 | International Journal of Electronicsand Communications2011，65，5： | 1 |
| 13 | Toughened plastics consisting of brittle particles and ductile matrix显示文摘 | KOO K K INOUE T MIYASAKA K | 1985 | Polymer Engineering Science1985，，25： | 1 |
| 14 | Prospects for in vivo Raman Spectroscopy 显示文摘 | HANLON E B MANOHARAN R KOO T W | 2000 | Physics in Medicine and Biology2000，45，2： | 1 |
| 15 | Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma显示文摘 | Koo GC Tan SY Tang T | 2012 | Cancer Discov2012，2，7： | 1 |
| 16 | Preparation of high-Tc superconducting oxide in the Bi-Sr-Ca-Cu-O system by oxalate gel processing显示文摘 | Chen F H Koo H S Tseng T Y | 1989 | Mater Lett1989，8，67： | 1 |
| 17 | Stable model reference adaptive fuzzy control of a class of nonlinear systems显示文摘 | Koo T J | 2001 | IEEE Trans on Fuzzy Systems2001，9，4： | 1 |
| 18 | Enhancement of antitumor immunity of dendritic cells pulsed with heat -treated tumor lysate in murine pancreatic cancer显示文摘 | Kim HS Choo YS Koo T | 2006 | Immunol Lett2006，103，2： | 1 |
| 19 | Examination of a novel,specified local antibiotic therapy through polymethylmethacrylate capsules in a rabbit osteomyelitis model显示文摘 | Borzsei L Mintal T Koos Z | 2006 | Chemotherapy2006，52，2： | 1 |
| 20 | Heavy metal concentrations in diet and livers of black-crowned night heron Nycticorax nycticorax and grey heron Ardea cinerea chicks from Pyeongtaek, Korea显示文摘 | Kim J Koo T H | 2007 | Ecotoxicology2007，16，： | 1 |
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