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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | A method for computing acoustic fields based on the principle of wave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | The Journal of the Acoustic Society of American1989，88，： | 1 |
| 3 | A method for computing acoustic fields based on the principle of wave super- position 显示文摘 | KOOPMANN G H SONG L M FAHNLINE J B | 1989 | Journal of the acoustical society of America1989，86，6： | 1 |
| 4 | A method for computing acoustic fields based on the prineiple of wave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | The Journal of the Acoustical Society ofAmerica1989，86，6： | 1 |
| 5 | A method for computing acoustic fields based on the principle of wave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | Journal of the Acoustical Society of America1989，86，6： | 1 |
| 6 | A method for computing acoustic fields based on the principle of wave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | J Acoust Soc Am1989，86，： | 1 |
| 7 | Numerrical errors associated with the method of superposition for computing acoustic fields显示文摘 | Song L Koopmann G H Fahnline J B | 1991 | J Acoust Soc Am1991，89，： | 1 |
| 8 | A method for computing acoustic fields based on the principle ofwave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | J Acoust Soc Am1989，86，： | 1 |
| 9 | A numerical solution for the general radiation problem based on the combined methods of superposition and singular-value deeomposition显示文摘 | Fahnline J B Koopmann G H | 1991 | J Acoust Soc Am1991，90，5： | 1 |
| 10 | Numeric errors associated with the method of superposition for computing acoustic fields显示文摘 | SONG L KOOPMANN G H FAHNLINE J B | 1991 | Journal of Acoustic Society America1991，89，6： | 1 |
| 11 | Unique cardiac Purkinje fiber transient outward current beta-sub- unit composition: a potential molecular link to idiopathic ventricular fibrillation 显示文摘 | XIAO L KOOPMANN T T ORDOG B | 2013 | Circ Res2013，112，10： | 1 |
| 12 | A method for computing acoustic fields based on the principle of wave superposition 显示文摘 | KOOPMANN G H SONGL FAHNLINE J B | 1989 | Journal of Acoustic Society of America1989，86，6： | 1 |
| 13 | A method for computing acoustic fields based on the principle of wave superposition 显示文摘 | KOOPMANN G H SONG L FAHNLINE J B | 1989 | Journal of Acoustic Society America1989，86，6： | 1 |
| 14 | Numerical errors associated with the method of superposition for computing acoustic fields 显示文摘 | SONG L KOOPMANN G H FAHNLINE J B | 1991 | Journal of Acoustic Society America1991，89，6： | 1 |
| 15 | A method for computering acoustic fields based on the princple of wave superposition 显示文摘 | Limin Song John B Fahniline | 1989 | The Journal of the Acoustical Society of America1989，86，6： | 1 |
| 16 | A method for computing acoustic fields based on the principle of wave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | J Acoust Soc Am1989，86，6： | 1 |
| 17 | Glacial and interglacial wind regimes over the eastern subtropical Atlantic and North-West Africa显示文摘 | Sarnthein M Tetzlaff G Koopmann B | 1981 | Nature1981，293，： | 1 |
| 18 | A method for computing acoustic fields based on the principle of wave superposition显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | J Acoust Soc Am1989，86，6： | 1 |
| 19 | A method for computing acoustic fields based on the principle of wave superposition显示文摘 | Koopmann G H Song LM Fahnline J B | 1989 | Journal of the Acoustical Society of America1989，86，6： | 1 |
| 20 | A method forcomputing acoustic fields based on the principle ofwave superposition 显示文摘 | Koopmann G H Song L Fahnline J B | 1989 | Journal of Acoustic SocietyAmerica1989，86，6： | 1 |
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