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| 1 | Helicobacter pylori infection and inflammatory bowel disease: Is there a link?显示文摘Helicobacter pylori(H.pylori)infection is one of the most widely spread infectious diseases in humans.It can cause chronic gastritis,peptic ulcer disease and gastric malignancies and has been associated with extra-gastric disorders.H.pylori elicit a chronic systemic inflammatory response which,under certain conditions,may trigger autoimmune reactions and may be implicated in the pathogenesis of autoimmune diseases.Although the pathogenesis of inflammatory bowel disease(IBD)is unknown,it is thought to result from complex interactions between environmental factors and microbiota in the gut of individuals who are genetically susceptible.Several bacterial and viral agents have been implicated in the aetiology of IBD.In theory,H.pylori infection could be involved in the pathogenesis of IBD by inducing alterations in gastric and/or intestinal permeability or by causing immunological derangements resulting in absorption of antigenic material and autoimmunity via various immunological pathways.Similar mechanisms may also be responsible for the co-existence of IBD with other autoimmune diseases and/or extra-intestinal manifestations.However,the epidemiological data fail to support this association.Infact,various studies indicate that the prevalence of H.pylori infection is low in patients with IBD,suggesting a protective role for this infection in the development of IBD.In this report,we aim to shed light on proposed mechanisms and confounding factors underlying the potential link between H.pylori infection and IBD. | Konstantinos Papamichael Panagiotis Konstantopoulos Gerassimos J Mantzaris | 2014 | World Journal of Gastroenterology2014，20，21： | 33 |
| 2 | Contribution of G71R mutation to Gilbert's syndrome phenotype in a Greek patient: A case report显示文摘Gilbert's syndrome is characterized by a benign indirect hyperbilirubinemia.It has often been underestimated and undiagnosed because of its mild symptoms;al-though it is not as rare as was once believed when its frequency was estimated using data originating from biochemical tests.Based on molecular techniques,the occurrence of Gilbert's syndrome has changed,increas-ing to 10% in the Caucasian population.This molecular defect was described,by Bosma et al,in 1995,and af-fects the promoter region of the UGT 1A1 gene.In this case report,our aim is to present a new combination of two molecular defects in a Greek patient with Gilbert' s syndrome.A 13-year-old Greek girl was examined for Gilbert's syndrome using molecular techniques,and an uncommon genotype was revealed comprising the rare mutation G71R in trans with A(TA)7TAA motif.TheG71R mutation according to the literature,as well as our epidemiological data,is rare in Caucasians,while it is common in Asian populations.This is the first case study in the Greek population to report a new genotype for Gilbert's syndrome manifestation in the Caucasian population. | Vassiliki Kalotychou Maria Karakosta Revekka Tzanetea Aleka Stamoulakatou Kostas Konstantopoulos Yannis Rombos | 2011 | World Journal of Gastrointestinal Pharmacology and Therapeutics2011，2，5： | 3 |
| 3 | Insulin and insulin-like growth factor-1 stimulate dephosphorylation of paxillin in parallel with focal adhesion kinase显示文摘 | Clark S | 1996 | Biochem J1996，314，： | 1 |
| 4 | Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta显示文摘 | Yuan M Konstantopoulos N Lee J | 2001 | Science2001，293，5535： | 1 |
| 5 | Reversal of obesity-and dietinduced insulin resistance with salicylates or targeted disruption of Ikkbeta显示文摘 | Yuan M Konstantopoulos N Lee J | | 0，，5535： | 1 |
| 6 | Reversal of obesity and diet induced insulin resistance with salieylates or targeted disruption of ikk显示文摘 | Yuan M Konstantopoulos N Lee J | 2001 | Science2001，293，5535： | 1 |
| 7 | Reversal of obesity and diet-induced insulin resistance with salicylates or targeted disruption of ikkbeta显示文摘 | Yuan M Konstantopoulos N Lee J | | 0，，5535： | 1 |
| 8 | Cancer cells in transit: the vascular interactions of tumor cells显示文摘 | Konstantopoulos K Thomas SN | 2009 | Annu Rev Biomed Eng2009，11，： | 1 |
| 9 | Effective Determination of Mobile Agent Itineraries for Data Aggregation on Sensor Networks显示文摘 | Konstantopoulos C Mpitziopoulos A Gavalas D | 2010 | IEEE Transactions on Knowledge and Data Engineering2010，22，12： | 1 |
| 10 | Reversal of obesity- end diet- induced insulin resistance with salicylates or Izrgeted disruption of lkk显示文摘 | Minsheng Y Konstantopoulos N Lee J | 2001 | Science2001，293，： | 1 |
| 11 | Reversal of obesity- and diet-induced insulin resistance with salicylates or tar- geted disruption of Ikkbeta 显示文摘 | YUAN M KONSTANTOPOULOS N LEE J | 2001 | Science2001，293，5535： | 1 |
| 12 | Effective treatment of kaposiformhemangioendotheliomas associated with Kasabach-Merritt phenomenon using four-drug regimen显示文摘 | Hauer J Graubner U Konstantopoulos N | | 0，，： | 1 |
| 13 | Reversal of obesity and diet-induced insulin resistance with salicylates or targeted disruption ofIKKbeta 显示文摘 | Yuan M Konstantopoulos N Lee J | 2001 | Science2001，293，： | 1 |
| 14 | Reversal of obesity-and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta显示文摘 | Yuan M Konstantopoulos N Lee J | 2001 | Science2001，293，5535： | 1 |
| 15 | Venous levels of shear support neutrophil-platelet adhesion and neutrophil aggregation in blood via P-selectin and β2-integrin显示文摘 | Konstantopoulos K Neelamegham S Burns A R | 1998 | Circulation1998，98，： | 1 |
| 16 | Epitelial-mesenchymal transition and fibrosis are mutually exclusive reponses in shear-activated proximal tubular epithelial cells 显示文摘 | Grabias BM Konstantopoulos K | 2012 | FASEB J2012，26，10： | 1 |
| 17 | Prostaglandin E2 induces interleukin -6 expression in human chondrocytes via cAMP/protein kinase A and phosphatidylinositol 3 kinase dependent NF- kappaB activation 显示文摘 | Wang P Zhu F Konstantopoulos K | 2010 | Am J Physiol Cell Physiol2010，298，： | 1 |
| 18 | Cancer cells in transit: the vascular interactions of tumor cells显示文摘 | Konstantopoulos K Thomas SN | 2009 | Annu Rev Biomed Eng2009，，11： | 1 |
| 19 | How large are teacher effects? 显示文摘 | Nye B Konstantopoulos s Hedges L V | 2004 | Educational Evaluation and Policy Analysis2004，26，3： | 1 |
| 20 | Evaluation of a novel monoclonal enzyme immunoassay for detection of Helicobacter pylori antigen in stool from children 显示文摘 | Koletzko S Konstantopoulos N Bosman D | 2003 | Gut2003，52，6： | 1 |
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