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| 1 | Spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin显示文摘A biologically active antibacterial reagent, 2–amino-6-hydroxy–4–(4-N, N-dimethylaminophenyl)-pyrimidine-5-carbonitrile(AHDMAPPC), was synthesized. It was employed to investigate the binding interaction with the bovine serum albumin(BSA) in detail using different spectroscopic methods. It exhibited antibacterial activity against Escherichia coli and Staphylococcus aureus which are common food poisoning bacteria. The experimental results showed that the fluorescence quenching of model carrier protein BSA by AHDMAPPC was due to static quenching. The site binding constants and number of binding sites(n E 1) were determined at three different temperatures based on fluorescence quenching results. The thermodynamic parameters, enthalpy change(ΔH), free energy(ΔG) and entropy change(ΔS) for the reaction were calculated to be 15.15 k J/mol, –36.11 k J/mol and 51.26 J/mol K according to van't Hoff equation, respectively. The results indicated that the reaction was an endothermic and spontaneous process, and hydrophobic interactions played a major role in the binding between drug and BSA. The distance between donor and acceptor is 2.79 nm according to F?rster's theory. The alterations of the BSA secondary structure in the presence of AHDMAPPC were confirmed by UV–visible, synchronous fluorescence, circular dichroism(CD) and three-dimensional fluorescence spectra. All these results indicated that AHDMAPPC can bind to BSA and be effectively transported and eliminated in the body. It can be a useful guideline for further drug design. | Vishwas D. Suryawansht Laxman S. Walekar Anil H. Gore Prashant V. Anbhule Govind B. Kolekar | 2016 | Journal of Pharmaceutical Analysis2016，6，1： | 7 |
| 2 | 用椰壳制活性炭吸附去除三价铋离子(英文)显示文摘In present study,we report the preparation of coconut shell activated carbon as adsorbent and its appli-cation for Bi(Ⅲ) removal from aqueous solutions.The developed adsorbent was characterized with scanning elec-tron microscope(SEM),Fourier Transform Infrared(FTIR),C,H,N,S analyzer,and BET surface area analyzer.The parameters examined include agitation time,initial concentration of Bi(Ⅲ),adsorbent dose and temperature.The maximum adsorption of Bi(Ⅲ)(98.72%) was observed at 250 mg·L-1 of Bi(Ⅲ) and adsorbent dose of 0.7 g when agitation was at 160 r·min-1 for 240 min at(299±2) K.The thermodynamic parameters such as Gibb's free energy(△Gθ),enthalpy(△Hθ) and entropy(△Sθ) were evaluated.For the isotherm models applied to adsorption study,the Langmuir isotherm model fits better than the Freundlich isotherm.The maximum adsorption capacity from the Langmuir isotherm was 54.35 mg?g?1 of Bi(Ⅲ).The kinetic study of the adsorption shows that the pseudo second order model is more appropriate than the pseudo first order model.The result shows that,coconut shell ac-tivated carbon is an effective adsorbent to remove Bi(Ⅲ) from aqueous solutions with good adsorption capacity. | SARTAPE Ashish MANDHARE Aniruddha SALVI Prathmesh PAWAR Dattatraya RAUT Prakash ANUSE Mansing KOLEKAR Sanjay | 2012 | Chinese Journal of Chemical Engineering2012，20，4： | 3 |
| 3 | Hidden Markov model based epileptic seizure detection using tunable Q wavelet transform显示文摘Epilepsy is one of the most prevalent neurological disorders affecting 70 million people worldwide.The present work is focused on designing an efficient algorithm for automatic seizure detection by using electroencephalogram(EEG) as a noninvasive procedure to record neuronal activities in the brain.EEG signals' underlying dynamics are extracted to differentiate healthy and seizure EEG signals.Shannon entropy,collision entropy,transfer entropy,conditional probability,and Hjorth parameter features are extracted from subbands of tunable Q wavelet transform.Efficient decomposition level for different feature vector is selected using the Kruskal-Wallis test to achieve good classification.Different features are combined using the discriminant correlation analysis fusion technique to form a single fused feature vector.The accuracy of the proposed approach is higher for Q=2 and J=10.Transfer entropy is observed to be significant for different class combinations.Proposed approach achieved 100% accuracy in classifying healthy-seizure EEG signal using simple and robust features and hidden Markov model with less computation time.The proposed approach efficiency is evaluated in classifying seizure and non-seizure surface EEG signals.The system has achieved 96.87% accuracy in classifying surface seizure and nonseizure EEG segments using efficient features extracted from different J level. | Deba Prasad Dash Maheshkumar H Kolekar | 2020 | The Journal of Biomedical Research2020，34，3： | 2 |
| 4 | Correlation between structural, magnetic, and dielectric properties of manganese substituted cobalt ferrite显示文摘 | Ramana C V Kolekar Y D Kamala Bharathi K | 2013 | Journal of Applied Physics2013，114，： | 1 |
| 5 | A white matter stroke model in the mouse:axonal damage,progenitor responses and MRI correlates显示文摘 | Sozmen EG Kolekar A Havton LA | | 0，，02： | 1 |
| 6 | Struc-tural, electrical and magnetic characterizationsof Ni - Cu-Zn ferrite synthesized by citrate precursor method 显示文摘 | JADHAV P A DEVAN R S KOLEKAR YD | 2009 | JPhy Chem Solid2009，70，： | 1 |
| 7 | Decolorization and biodegradation of azo dye Reactive Blue 59 by aerobic granules显示文摘 | Kolekar Y M Nemade H N Markad V L | 2012 | Bioresour Technol2012，104，： | 1 |
| 8 | Interpenetrating polymer networks baaed on polyol modified castor oil polyurethane and polymethyl methacrylate显示文摘 | Athawale V Kolekar S | 1998 | European Polymer Journal1998，34，10： | 1 |
| 9 | Recent developments in polyurethanes and poly(acrylates) interpenetrating Polymer networks 显示文摘 | Athawale V D Kolekar S I Raut S S | 2003 | polym Eng Sci2003，43，1： | 1 |
| 10 | 查看详情显示文摘 | Dasgupta S Banerjee K Utture S Kusari P. Wagh S. Dhumal K. Kolekar S. Adsule P.G | | 0，，： | 1 |
| 11 | Interpenetrating polymer networks based on polyol modified castor oil polyurethaneand polymethyl methacrylate 显示文摘 | ATHAWALE V KOLEKAR S | 1998 | Eur Polym J1998，34，10： | 1 |
| 12 | Decolorization and biodegradation of azo dye, reac- tive blue 59 by aerobic granules显示文摘 | Kolekar Y M Nemade H N Markad V L | 2012 | Bioresource Tech- nology2012，104，： | 1 |
| 13 | Survey and simulation base performance analysis of tcp-variants in terms of throughput,delay and drop packets over MANETs显示文摘 | Khelage PB Kolekar DU | 2014 | International Journal of Scientific&Engineering Research2014，5，1： | 1 |
| 14 | Selective liquid-liquid extraction of platinum(Ⅳ) from ascorbate media by N-n-octylaniline: Its separation from associated elements and real samples 显示文摘 | Kolekar S S | 2003 | Separation Science and Technology2003，38，11： | 1 |
| 15 | Semantic concept mining based on hierarchical event detection for soccer video indexing显示文摘 | Kolekar M H Palaniappan K Sengupta S | 2009 | Journal of Multimedia2009，4，5： | 1 |
| 16 | Neutron measurements using the SSNTD tech- nique during prototype fast breeder reactor bulk shielding experiments显示文摘 | JOSHI V B KOLEKAR R V DRAVID H K | 2003 | Radiation Measure ments2003，36，： | 1 |
| 17 | Spectrofluorimetric Studies of the Interaction Between Quinine Sulfate and Riboflavin显示文摘 | Patil D Bhattar S L Kolekar G B | 2011 | Solution Chem2011，40，2： | 1 |
| 18 | A white matter stroke model in the mouse: Axonal damage, progenitor responses and MRI correlates显示文摘 | Sozmen EG Kolekar A Havton LA | 2009 | Neuroscis Methods2009，180，2： | 1 |
| 19 | A white matterstroke model in the mouse:axonal damage,progenitor responsesand MRI correlates显示文摘 | Sozmen EG Kolekar A Havton LA | 2009 | J Neuroscience Methods2009，180，2： | 1 |
| 20 | Interpenetrating polymer networks based on oil modified castor oil urethane and poly (methyl methacrylate)显示文摘 | Athawale V Kolekar S | 2000 | Journal of Macromolecular Science-Pure and Applied Chemistry2000，37，12： | 1 |
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